Recombinant Human ARAP3, His-tagged

• Cat.No.: ARAP3-9792H
• Product Overview: Recombinant Human ARAP3 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: C-term-320a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [ Homo sapiens ]
• Official Symbol: ARAP3
• Synonyms: ARAP3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3; centaurin, delta 3 , CENTD3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; DRAG1; FLJ21065; cnt-d3; centaurin-delta-3; centaurin, delta 3; PtdIns(3,4,5)P3-binding protein; phosphoinositide binding protein; Arf and Rho GAP adapter protein 3; ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3; CENTD3
• Gene ID: 64411
• mRNA Refseq: NM_022481
• Protein Refseq: NP_071926
• MIM: 606647
• UniProt ID: Q8WWN8
• Chromosome Location: 5q31.3
• Pathway: Class I PI3K signaling events, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Regulation of RhoA activity, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by Rho GTPases, organism-specific biosystem
• Function: ARF GTPase activator activity; NOT Rac GTPase activator activity; Rho GTPase activator activity; Rho GTPase activator activity; metal ion binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; zinc ion bi