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ARHGAP12

  • Official Full Name

    Rho GTPase activating protein 12

  • Overview

    This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP);metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion;and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms

    ARHGAP12; Rho GTPase activating protein 12; rho GTPase-activating protein 12; FLJ10971; FLJ20737; FLJ21785; Rho type GTPase activating protein 12; rho-type GTPase-activating protein 12;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGAP12-761H Recombinant Human ARHGAP12 protein, GST-tagged Wheat Germ GST
Human ARHGAP12-108HCL Recombinant Human ARHGAP12 cell lysate N/A
Human ARHGAP12-1509HF Recombinant Full Length Human ARHGAP12 Protein, GST-tagged In Vitro Cell Free System GST 841 amino acids
Mouse ARHGAP12-1854M Recombinant Mouse ARHGAP12 Protein Mammalian Cell His
Mouse ARHGAP12-670M-B Recombinant Mouse ARHGAP12 Protein Pre-coupled Magnetic Beads HEK293
Mouse ARHGAP12-670M Recombinant Mouse ARHGAP12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ARHGAP12-388R Recombinant Rhesus monkey ARHGAP12 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ARHGAP12-217R Recombinant Rhesus Macaque ARHGAP12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ARHGAP12-217R-B Recombinant Rhesus Macaque ARHGAP12 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARHGAP12 involved in several pathways and played different roles in them. We selected most pathways ARHGAP12 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rho GTPase cycleARHGAP1;MYO9B;AKAP13;STARD13;ARAP1;ARHGAP17;ARHGAP22;PLEKHG2;ARHGAP29
Signal TransductionPYGO2;RHPN1;GPBAR1;LGR6;OR4D2;EVC2;DNAL4B;SAGB;NPFF
Signaling by Rho GTPasesARHGAP17B;IQGAP3;ARAP1;STARD13;MKL1B;ARHGEF16;PRC1;ARHGAP40;RTKN

ARHGAP12 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP12 itself. We selected most functions ARHGAP12 had, and list some proteins which have the same functions with ARHGAP12. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityTBC1D15;RGS12;TBC1D25;SIPA1L1;RASA1;RGS12B;TBC1D3;AXIN2;SGSM3

ARHGAP12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP12.

SRPK2; SRPK1; MAPK11

  • Q&As
  • Reviews

Q&As (10)

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Is ARHGAP12 conserved across different species? 11/20/2022

Yes, ARHGAP12 is conserved across diverse species, from mammals to invertebrates. This suggests that it plays a fundamental role in cellular processes and is under evolutionary selective pressure. The conservation of ARHGAP12 highlights its importance in various biological contexts and suggests that its functions are highly conserved throughout evolution.

Has the ARHGAP12 protein been implicated in any specific biological processes? 08/27/2022

Yes, the ARHGAP12 protein has been associated with processes such as neuronal development, cell migration, cell adhesion, and cell polarity. It plays a role in maintaining proper cellular cytoskeletal dynamics and contributes to the overall integrity and function of cells.

Can mutations in the ARHGAP12 gene lead to any functional changes in the protein? 05/13/2022

While specific mutations in the ARHGAP12 gene have not been extensively studied, it is plausible that mutations could affect the protein's ability to regulate Rho GTPases and subsequently impact cellular processes like cytoskeletal organization and cell migration.

Can ARHGAP12 be targeted for therapeutic purposes? 05/27/2020

Given its involvement in various diseases, including cancer and neurodevelopmental disorders, ARHGAP12 holds potential as a therapeutic target. Modulating ARHGAP12 activity or expression could potentially impact the pathological processes associated with these conditions. However, further research is necessary to fully understand the precise mechanisms and potential therapeutic strategies involving ARHGAP12.

Can variations in the ARHGAP12 gene contribute to disease susceptibility? 08/21/2019

While specific variations in the ARHGAP12 gene have not been extensively studied in the context of disease susceptibility, it is plausible that genetic variants within the gene could influence disease risk. Mutations or altered expression levels of other Rho GTPase regulators have been associated with disease. Therefore, it is conceivable that variations in the ARHGAP12 gene could potentially contribute to disease susceptibility, although further research is needed to determine the extent of its involvement.

Are there any known post-translational modifications of ARHGAP12? 10/26/2017

Although the post-translational modifications of ARHGAP12 have not been extensively studied, it has been reported that ARHGAP12 can undergo phosphorylation at specific sites. Phosphorylation of ARHGAP12 may regulate its activity, subcellular localization, or interactions with other proteins. Additionally, further investigation may reveal additional post-translational modifications that could influence ARHGAP12 function.

Is there any specific research on the role of ARHGAP12 in the nervous system? 12/16/2016

Yes, there has been research on the role of ARHGAP12 in the nervous system. It has been implicated in neuronal morphogenesis, axon guidance, and synaptic plasticity. Studies have shown that ARHGAP12 regulates cytoskeletal dynamics in neurons, impacting dendritic spine formation and neuronal connectivity. Dysregulation of ARHGAP12 in the brain has been associated with neurodevelopmental disorders like autism spectrum disorder.

Are there any known interactions of ARHGAP12 with other proteins? 10/14/2016

Yes, ARHGAP12 has been found to interact with multiple proteins. For instance, it can form complexes with Rho GTPases, such as RhoA, RhoB, and RhoC, and regulate their activity. It also interacts with other cytoskeletal proteins, including actin and myosin, thereby influencing cytoskeletal organization and dynamics. Furthermore, ARHGAP12 has been shown to interact with other signaling molecules and scaffolding proteins, suggesting its involvement in various cellular signaling networks.

Are there any research studies investigating the ARHGAP12 protein? 04/14/2016

Yes, there are ongoing research studies exploring the functions and mechanisms of ARHGAP12. These studies aim to better understand the protein's role in cellular processes and its potential implications in disease development.

Are there any known drugs or therapies targeting the ARHGAP12 protein? 02/13/2016

Currently, there are no specific drugs or therapies specifically targeting ARHGAP12 for clinical use. However, understanding the protein's role in various diseases may lead to the development of targeted therapies in the future.

Customer Reviews (8)

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Reviews
08/17/2022

    the manufacturer offers a wide range of ARHGAP12 protein variants, including recombinant or native forms, as well as different conjugates and modifications.

    04/22/2021

      As a researcher using ARHGAP12 protein, I have found numerous advantages in its application during trials for various experimental purposes.

      05/21/2020

        In protein electron microscopy structure analysis, ARHGAP12 protein proved to be an invaluable tool, allowing for the precise determination of protein structures with remarkable clarity and resolution.

        04/23/2020

          I enthusiastically endorse ARHGAP12 protein as it delivers exceptional performance in a wide range of applications.

          08/12/2019

            In my ELISA experiments, ARHGAP12 protein consistently provided reliable and reproducible results, with high sensitivity and specificity.

            05/08/2019

              Should I encounter any challenges or require technical assistance, the manufacturer provides prompt and knowledgeable support.

              03/11/2018

                This unequivocal detection and visualization of protein bands were instrumental in facilitating accurate analysis and interpretation of my experimental data.

                10/07/2017

                  They are readily available to address any concerns or questions and supply valuable resources to assist in experimental design and optimization.

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