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Recombinant Human ARHGAP12 protein, GST-tagged

Cat.No. : ARHGAP12-761H
Product Overview : Human ARHGAP12 full-length ORF ( AAH94719.1, 1 a.a. - 841 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 122.2 kDa
AA Sequence : MKMADRSGKIIPGQVYIEVEYDYEY EAKDRKIVIKQGERYILVKKTNDDW WQVKPDENSKAFYVPAQYVKEVTRK ALMPPVKQVAGLPNNSTKIMQSLHL QRSTENVNKLPELSSFGKPSSSVQG TGLIRDANQNFGPSYNQGQTVNLSL DLTHNNGKFNNDSHSPKVSSQNRTR SFGHFPGPEFLDVEKTSFSQEQSCD SAGEGSERIHQDSESGDELSSSSTE QIRATTPPNQGRPDSPVYANLQELK ISQSALPPLPGSPAIQINGEWETHK DSSGRCYYYNRGTQERTWKPPRWTR DASISKGDFQNPGDQELLSSEENYY STSYSQSDSQCGSPPRGWSEELDER GHTLYTSDYTNEKWLKHVDDQGRQY YYSADGSRSEWELPKYNASSQQQRE IIKSRSLDRRLQEPIVLTKWRHSTI VLDTNDKESPTASKPCFPENESSPS SPKHQDTDQEKYGLLNVTKIAENGK KVRKNWLSSWAVLQGSSLLFTKTQG SSTSWFGSNQSKPEFTVDLKGATIE MASKDKSSKKNVFELKTRQGTELLI QSDNDTVINDWFKVLSSTINNQAVE TDEGIEEEIPDSPGIEKHDKEKEQK DPKKLRSFKVSSIDSSEQKKTKKNL KKFLTRRPTLQAVREKGYIKDQVFG SNLANLCQRENGTVPKFVKLCIEHV EEHGLDIDGIYRVSGNLAVIQKLRF AVNHDEKLDLNDSKWEDIHVITGAL KMFFRELPEPLFTFNHFNDFVNAIK QEPRQRVAAVKDLIRQLPKPNQDTM QILFRHLRRVIENGEKNRMTYQSIA IVFGPTLLKPEKETGNIAVHTVYQN QIVELILLELSSIFGR
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ARHGAP12 Rho GTPase activating protein 12 [ Homo sapiens ]
Official Symbol : ARHGAP12
Synonyms : ARHGAP12; Rho GTPase activating protein 12; rho GTPase-activating protein 12; FLJ10971; FLJ20737; FLJ21785; rho-type GTPase-activating protein 12; FLJ45709; DKFZp779N2050;
Gene ID : 94134
mRNA Refseq : NM_018287
Protein Refseq : NP_060757
MIM : 610577
UniProt ID : Q8IWW6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Is ARHGAP12 conserved across different species? 11/20/2022

Yes, ARHGAP12 is conserved across diverse species, from mammals to invertebrates. This suggests that it plays a fundamental role in cellular processes and is under evolutionary selective pressure. The conservation of ARHGAP12 highlights its importance in various biological contexts and suggests that its functions are highly conserved throughout evolution.

Has the ARHGAP12 protein been implicated in any specific biological processes? 08/27/2022

Yes, the ARHGAP12 protein has been associated with processes such as neuronal development, cell migration, cell adhesion, and cell polarity. It plays a role in maintaining proper cellular cytoskeletal dynamics and contributes to the overall integrity and function of cells.

Can mutations in the ARHGAP12 gene lead to any functional changes in the protein? 05/13/2022

While specific mutations in the ARHGAP12 gene have not been extensively studied, it is plausible that mutations could affect the protein's ability to regulate Rho GTPases and subsequently impact cellular processes like cytoskeletal organization and cell migration.

Can ARHGAP12 be targeted for therapeutic purposes? 05/27/2020

Given its involvement in various diseases, including cancer and neurodevelopmental disorders, ARHGAP12 holds potential as a therapeutic target. Modulating ARHGAP12 activity or expression could potentially impact the pathological processes associated with these conditions. However, further research is necessary to fully understand the precise mechanisms and potential therapeutic strategies involving ARHGAP12.

Can variations in the ARHGAP12 gene contribute to disease susceptibility? 08/21/2019

While specific variations in the ARHGAP12 gene have not been extensively studied in the context of disease susceptibility, it is plausible that genetic variants within the gene could influence disease risk. Mutations or altered expression levels of other Rho GTPase regulators have been associated with disease. Therefore, it is conceivable that variations in the ARHGAP12 gene could potentially contribute to disease susceptibility, although further research is needed to determine the extent of its involvement.

Are there any known post-translational modifications of ARHGAP12? 10/26/2017

Although the post-translational modifications of ARHGAP12 have not been extensively studied, it has been reported that ARHGAP12 can undergo phosphorylation at specific sites. Phosphorylation of ARHGAP12 may regulate its activity, subcellular localization, or interactions with other proteins. Additionally, further investigation may reveal additional post-translational modifications that could influence ARHGAP12 function.

Is there any specific research on the role of ARHGAP12 in the nervous system? 12/16/2016

Yes, there has been research on the role of ARHGAP12 in the nervous system. It has been implicated in neuronal morphogenesis, axon guidance, and synaptic plasticity. Studies have shown that ARHGAP12 regulates cytoskeletal dynamics in neurons, impacting dendritic spine formation and neuronal connectivity. Dysregulation of ARHGAP12 in the brain has been associated with neurodevelopmental disorders like autism spectrum disorder.

Are there any known interactions of ARHGAP12 with other proteins? 10/14/2016

Yes, ARHGAP12 has been found to interact with multiple proteins. For instance, it can form complexes with Rho GTPases, such as RhoA, RhoB, and RhoC, and regulate their activity. It also interacts with other cytoskeletal proteins, including actin and myosin, thereby influencing cytoskeletal organization and dynamics. Furthermore, ARHGAP12 has been shown to interact with other signaling molecules and scaffolding proteins, suggesting its involvement in various cellular signaling networks.

Are there any research studies investigating the ARHGAP12 protein? 04/14/2016

Yes, there are ongoing research studies exploring the functions and mechanisms of ARHGAP12. These studies aim to better understand the protein's role in cellular processes and its potential implications in disease development.

Are there any known drugs or therapies targeting the ARHGAP12 protein? 02/13/2016

Currently, there are no specific drugs or therapies specifically targeting ARHGAP12 for clinical use. However, understanding the protein's role in various diseases may lead to the development of targeted therapies in the future.

Customer Reviews (8)

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Reviews
08/17/2022

    the manufacturer offers a wide range of ARHGAP12 protein variants, including recombinant or native forms, as well as different conjugates and modifications.

    04/22/2021

      As a researcher using ARHGAP12 protein, I have found numerous advantages in its application during trials for various experimental purposes.

      05/21/2020

        In protein electron microscopy structure analysis, ARHGAP12 protein proved to be an invaluable tool, allowing for the precise determination of protein structures with remarkable clarity and resolution.

        04/23/2020

          I enthusiastically endorse ARHGAP12 protein as it delivers exceptional performance in a wide range of applications.

          08/12/2019

            In my ELISA experiments, ARHGAP12 protein consistently provided reliable and reproducible results, with high sensitivity and specificity.

            05/08/2019

              Should I encounter any challenges or require technical assistance, the manufacturer provides prompt and knowledgeable support.

              03/11/2018

                This unequivocal detection and visualization of protein bands were instrumental in facilitating accurate analysis and interpretation of my experimental data.

                10/07/2017

                  They are readily available to address any concerns or questions and supply valuable resources to assist in experimental design and optimization.

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