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ARHGEF10

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 10

  • Overview

    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals.
  • Synonyms

    ARHGEF10; Rho guanine nucleotide exchange factor (GEF) 10; rho guanine nucleotide exchange factor 10; Gef10; KIAA0294; ARHGA_HUMAN; DKFZp686H0726; MGC131664;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGEF10-9832H Recombinant Human ARHGEF10, GST-tagged E.coli GST 400-700a.a.
Human ARHGEF10-778H Recombinant Human ARHGEF10 protein, GST-tagged Wheat Germ GST
Human ARHGEF10-779H Recombinant Human ARHGEF10 protein, GST-tagged Wheat Germ GST
Human ARHGEF10-116HCL Recombinant Human ARHGEF10 cell lysate N/A
Human ARHGEF10-1144HF Recombinant Full Length Human ARHGEF10 Protein, GST-tagged In Vitro Cell Free System GST 380 amino acids
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARHGEF10 Related Articles

ARHGEF10 involved in several pathways and played different roles in them. We selected most pathways ARHGEF10 participated on our site, such as Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Regulation of RhoA activityARHGEF10L;ARHGEF15;DEF6;ARHGEF18;NET1;ARHGAP9;ARHGEF3;MYO9B;ARHGEF25

ARHGEF10 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, kinesin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF10 itself. We selected most functions ARHGEF10 had, and list some proteins which have the same functions with ARHGEF10. You can find most of the proteins on our site.

Function Related Protein
Rho guanyl-nucleotide exchange factor activityTRIOA;TRIO;DOCK10;FGD6;ARHGEF3L;ARHGEF9B;PLEKHG5;ARHGEF33;DNMBP
kinesin bindingKLC3;PIFO;KIF1B;ATCAY;NEK6;ARPC2;SERPINB1A;TOR1A;DISC1
protein bindingCOG4;EVL;MAPT;CCNA2;TRIM72;GRASP;CNOT8;GEMIN7;LANCL1

ARHGEF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF10.

KIF3B; WDR48

Huang, IH; Hsiao, CT; et al. GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment. JOURNAL OF CELL SCIENCE 127:4186-4200(2014).
Martin, E; Harel, S; et al. pix-1 Controls Early Elongation in Parallel with mel-11 and let-502 in Caenorhabditis elegans. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (14)

Ask a question
Can ARHGEF10 be used as a diagnostic or prognostic marker for any diseases? 01/24/2023

The diagnostic or prognostic utility of ARHGEF10 as a marker for diseases is still under investigation. While dysregulation of ARHGEF10 has been observed in some diseases, its precise role as a diagnostic or prognostic marker is yet to be firmly established. Further studies are needed to determine its clinical significance and potential as a biomarker in specific disease contexts.

Is ARHGEF10 associated with any signaling pathways? 06/12/2022

ARHGEF10 is primarily involved in signaling pathways related to Rho GTPases. It promotes the activation of RhoA, RhoB, and RhoC by facilitating the exchange of GDP (guanosine diphosphate) for GTP (guanosine triphosphate). Activation of these Rho GTPases regulates downstream signaling cascades that control cellular processes such as actin cytoskeleton organization and cell migration.

Is ARHGEF10 implicated in any specific diseases or conditions? 03/16/2022

Yes, ARHGEF10 has been implicated in several diseases and conditions. For example, studies have suggested that ARHGEF10 may play a role in cancer progression and metastasis. It has been found to be dysregulated in various cancer types, including breast cancer, prostate cancer, and colorectal cancer. Additionally, ARHGEF10 has been implicated in neurological disorders such as Parkinson's disease and Alzheimer's disease, where it may contribute to abnormal neuronal functions. However, further research is needed to fully understand the extent of ARHGEF10's involvement in these diseases.

Are there any known interacting proteins or protein complexes involving ARHGEF10? 08/06/2021

Yes, ARHGEF10 has been reported to interact with several proteins, contributing to its regulatory functions. For example, it interacts with members of the Rho family of GTPases, such as RhoA, RhoB, and RhoC, as well as with other Rho GEFs. Additionally, ARHGEF10 has been found to associate with various scaffolding proteins and cytoskeletal components, implicating its involvement in the formation of signaling complexes.

Are there any drugs or compounds that can modulate ARHGEF10 activity? 05/03/2021

As of now, there are no specific drugs or compounds available that directly target ARHGEF10 for modulation. However, given its involvement in various disease processes, including cancer and neurological disorders, there is ongoing research to identify small molecules or therapeutic interventions that can indirectly modulate ARHGEF10 activity or its downstream signaling pathways.

Are there any known mutations in the ARHGEF10 gene? 01/06/2021

Yes, mutations in the ARHGEF10 gene have been identified in certain diseases. For example, mutations in ARHGEF10 have been associated with neurodevelopmental disorders such as intellectual disability and developmental delay. These mutations are thought to disrupt the normal function of ARHGEF10 and its downstream signaling pathways, leading to abnormalities in neuronal development and function. However, the exact role of ARHGEF10 mutations in these disorders is still being investigated, and more research is needed to understand their implications.

Are there any known diseases or disorders associated with ARHGEF10 dysregulation? 09/18/2020

Yes, there are reports linking ARHGEF10 to certain diseases and disorders. For example, studies have implicated ARHGEF10 in the pathogenesis of neurological disorders such as Parkinson's disease and Alzheimer's disease. Additionally, dysregulation of ARHGEF10 has been observed in several types of cancer, including breast, lung, and gastric cancers.

Is ARHGEF10 expressed in all tissues? 04/05/2019

ARHGEF10 is expressed in a wide range of tissues, including but not limited to the brain, heart, kidneys, liver, lungs, and various immune cells. Its expression levels may vary between tissues and cell types, suggesting potential tissue-specific functions. However, further studies are required to elucidate the precise expression patterns of ARHGEF10 in different tissues and their significance in physiological and pathological processes.

Can ARHGEF10 be targeted for therapeutic purposes? 08/07/2018

Given its involvement in various diseases, targeting ARHGEF10 may hold therapeutic potential. However, it is important to note that specific drugs or therapeutic strategies targeting ARHGEF10 are not currently available. Further research is needed to better understand the mechanisms and functional consequences of ARHGEF10 dysregulation, which could potentially lead to the development of targeted therapies.

Can genetic variations or mutations in ARHGEF10 lead to disease susceptibility? 04/22/2018

There is currently limited information on the impact of genetic variations or mutations in ARHGEF10 on disease susceptibility. However, some studies have identified rare genetic variants in ARHGEF10 that may be associated with an increased risk of developing specific disorders, such as Parkinson's disease. Further research is needed to elucidate the significance of these variations and their impact on disease susceptibility.

Are there any known interactions between ARHGEF10 and other proteins? 11/09/2017

Yes, ARHGEF10 has been reported to interact with several proteins. For example, it interacts with Rho GTPases, such as RhoA and Rac1, which are key regulators of cellular processes like cytoskeletal organization and cell migration. ARHGEF10 also interacts with other signaling molecules and proteins involved in cellular processes, including kinases, phosphatases, and scaffolding proteins. These interactions contribute to the regulation of ARHGEF10's activity and its downstream signaling pathways.

Are there any known animal models or cell lines used to study ARHGEF10? 10/01/2016

Currently, there are no specific animal models or cell lines that are commonly used to study ARHGEF10. However, some studies have utilized knockout mouse models or manipulated ARHGEF10 expression in specific cell lines to investigate its functions in various biological processes.

Are there any known post-translational modifications of ARHGEF10? 08/23/2016

Yes, there have been reports of post-translational modifications of ARHGEF10. For instance, phosphorylation of ARHGEF10 by kinases such as protein kinase A (PKA) and protein kinase C (PKC) has been demonstrated to regulate its activity and function. Additionally, ARHGEF10 has been reported to undergo ubiquitination, a process that can target proteins for degradation or modulate their cellular localization and activity.

Can ARHGEF10 interact with membrane receptors? 08/01/2016

Yes, ARHGEF10 has been shown to interact with various membrane receptors. For instance, it has been reported to associate with receptor tyrosine kinases (RTKs) such as epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR). These interactions suggest that ARHGEF10 may contribute to the downstream signaling of these receptors and regulate cellular responses.

Customer Reviews (8)

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Reviews
09/12/2022

    The protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.

    10/10/2021

      The manufacturer can provide detailed documentation on the quality control measures undertaken during protein production and purification.

      08/19/2019

        ARHGEF10 protein may have a specific binding affinity or interaction with its target molecules or receptors, making it a valuable tool for targeted therapies or diagnostic applications.

        08/04/2019

          This guidance allows me to design and implement experiments effectively while adhering to best practices, enhancing the reliability and reproducibility of my results.

          05/05/2019

            the manufacturer's commitment to quality control is essential in achieving reliable and consistent outcomes

            05/09/2018

              This collaboration can involve sharing resources, expertise, and data to advance scientific understanding and therapeutic development.

              07/02/2016

                The manufacturer can offer technical expertise and guidance to researchers regarding the proper use, handling, and storage of ARHGEF10 protein.

                03/09/2016

                  The manufacturer of ARHGEF10 protein plays a crucial role in supporting my research efforts.

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