ARHGEF18
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Official Full Name
Rho/Rac guanine nucleotide exchange factor (GEF) 18
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Overview
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
ARHGEF18; Rho/Rac guanine nucleotide exchange factor (GEF) 18; rho guanine nucleotide exchange factor 18; KIAA0521; MGC15913; P114 RhoGEF; Rho specific guanine nucleotide exchange factor p114; SA-RhoGEF;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ARHGEF18-783H | Recombinant Human ARHGEF18 protein, GST-tagged | Wheat Germ | GST | ||
Human | ARHGEF18-9836H | Recombinant Human ARHGEF18, GST-tagged | E.coli | GST | 1-89a.a. | |
Human | ARHGEF18-1214H | Recombinant Human ARHGEF18 Protein (159-551 aa), GST-tagged | E.coli | GST | 159-551 aa | |
Human | ARHGEF18-1149HF | Recombinant Full Length Human ARHGEF18 Protein, GST-tagged | In Vitro Cell Free System | GST | 89 amino acids | |
Mouse | ARHGEF18-1893M | Recombinant Mouse ARHGEF18 Protein | Mammalian Cell | His | ||
Mouse | ARHGEF18-694M | Recombinant Mouse ARHGEF18 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ARHGEF18-694M-B | Recombinant Mouse ARHGEF18 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGEF18 involved in several pathways and played different roles in them. We selected most pathways ARHGEF18 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell death signalling via NRAGE, NRIF and NADE | ARHGEF9;ARHGEF18;ARHGAP4A;FGD2;TRIO;AATF;FGD4A;ITGB3BP;KALRNB |
G alpha (12/13) signalling events | GNA13;ARHGEF18;DCLRE1B;AKAP13;ADRA1B;ARHGAP4;TRIO;KALRNB;ARHGEF1A |
GPCR downstream signaling | ABHD12;ARHGAP4;CHRM4;RGS21;FFAR3;ADRA2C;PROKR2;RHOC;TRPC6A |
NRAGE signals death through JNK | OBSCN;ABR;FGD2;DCLRE1B;FGD4;ARHGEF16;ARHGEF9;ARHGEF17;AATF |
Regulation of RhoA activity | DEF6;ARHGEF28;OBSCN;ARHGEF25;ARHGEF10L;PLEKHG6;AKAP13;ABR;MYO9B |
Rho GTPase cycle | ARHGAP24;CHN1;FAM13B1;ARHGAP18;AKAP13;ECT2;DLC1;ARHGAP12B;ARHGAP36 |
Signal Transduction | KTN1;PTHRP2;S1PR5B;DISP2;DHRS4;STARD8;NRP2A;CALML4;TLE3B |
Signaling by GPCR | TAAR1;RGS11;PENKB;CCL35.1;GHRH;RGS14;ARHGEF1B;APLN;ARHGEF16 |
ARHGEF18 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF18 itself. We selected most functions ARHGEF18 had, and list some proteins which have the same functions with ARHGEF18. You can find most of the proteins on our site.
Function | Related Protein |
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Rho guanyl-nucleotide exchange factor activity | DOCK11;ECT2;ARHGEF7B;RASGRF2;ARHGEF40;PLEKHG4;FARP2;ARHGEF19;ABR |
guanyl-nucleotide exchange factor activity | VAV1;RASGRP3;KNDC1;GCGR;TBXA2R;ARHGEF18;SPATA13;FGD1;ARHGEF1B |
ARHGEF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF18.
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- Q&As
- Reviews
Q&As (14)
Ask a questionYes, mutations in the ARHGEF18 gene have been identified in individuals with neurodevelopmental disorders. These mutations are thought to disrupt the normal function of ARHGEF18 and contribute to cognitive impairments, intellectual disabilities, and developmental delays.
Beyond its roles in cancer and neuronal function, ARHGEF18 has also been implicated in other cellular processes. It contributes to the regulation of cell proliferation, cell adhesion, and cytoskeletal dynamics. Additionally, it may play a role in immune responses, as some studies have reported its involvement in the activation and migration of immune cells.
Yes, emerging evidence suggests that ARHGEF18 may be involved in the pathogenesis of certain diseases and disorders. Variants in ARHGEF18 have been implicated in neurodevelopmental disorders such as autism spectrum disorder and intellectual disability. Additionally, altered expression of ARHGEF18 has been linked to cancer progression and metastasis in various types of malignancies.
There is limited research on the role of genetic variations in ARHGEF18 and disease susceptibility. However, some studies have identified specific genetic variants in ARHGEF18 that may contribute to the risk or severity of certain conditions, including neurodevelopmental disorders and certain types of cancer.
ARHGEF18 primarily regulates the signaling pathways associated with Rho GTPases, such as RhoA, Rac1, and Cdc42. Activation of ARHGEF18 leads to the exchange of GDP for GTP on these GTPases, subsequently activating them and initiating downstream signaling cascades. These pathways play significant roles in cytoskeletal rearrangements, cell migration, cell adhesion, and synaptic plasticity.
ARHGEF18 is primarily associated with the Rho signaling pathway. As a guanine nucleotide exchange factor, it activates Rho GTPases, which in turn regulate downstream signaling cascades involved in various cellular processes. These include pathways associated with cell adhesion, migration, proliferation, and cytoskeletal dynamics.
Yes, ARHGEF18 is known to be involved in neuronal development and synaptic plasticity. It is expressed in the brain and contributes to the formation and maintenance of neuronal connections. Dysregulation of ARHGEF18 has been linked to neurodevelopmental disorders and neurodegenerative diseases.
There are currently no specific inhibitors or activators designed specifically for ARHGEF18. However, certain small molecules and compounds that target Rho GTPases, such as Rho kinase inhibitors or Rac1 activators, indirectly affect the activity of ARHGEF18 by modulating the downstream signaling pathways it participates in.
Genetic studies have identified rare variants in ARHGEF18 that are associated with an increased risk for autism spectrum disorder and intellectual disability. These variants may disrupt the normal function of ARHGEF18 in neuronal development and synaptic plasticity, leading to impairments in neural connectivity and associated behavioral abnormalities. Further research is ongoing to understand the specific molecular mechanisms through which ARHGEF18 contributes to these neurodevelopmental disorders.
Yes, ARHGEF18 can interact with several proteins to form protein complexes that regulate its function. Some known interacting partners include Rho GTPases (such as RhoA, Rac1, and Cdc42), other guanine nucleotide exchange factors, and cytoskeletal proteins involved in actin dynamics.
Yes, ARHGEF18 can interact with several proteins to mediate its cellular functions. These interactions may involve its binding to other guanine nucleotide exchange factors, Rho GTPases, or proteins involved in cytoskeletal dynamics and cell signaling. Some of the known interacting partners of ARHGEF18 include α-actinin, filamin, IQGAP1, and paxillin.
Given its involvement in cancer and neurodevelopmental disorders, ARHGEF18 holds potential as a therapeutic target. Identifying small molecules or approaches to modulate ARHGEF18 activity could potentially be explored to inhibit tumor metastasis or ameliorate symptoms associated with neurodevelopmental disorders. However, further research is needed to better understand the precise mechanisms of ARHGEF18 and its potential therapeutic applications.
Recent research on ARHGEF18 has focused on its role in neurodevelopmental disorders and cancer. Studies have identified genetic variants in ARHGEF18 associated with increased risk for autism spectrum disorder and intellectual disability. In cancer research, ARHGEF18 has been implicated in tumor metastasis and invasiveness. Additionally, the functional mechanisms and interacting partners of ARHGEF18 are continuously being investigated to better understand its role in cellular processes and associated pathologies.
ARHGEF18 promotes cell migration and invasion in cancer by activating Rho GTPases, particularly RhoA and Rac1, which regulate cytoskeletal rearrangements necessary for cell movement. ARHGEF18 expression is upregulated in cancer cells, leading to increased cell motility and invasiveness, which contribute to tumor metastasis.
Customer Reviews (8)
Write a reviewThe manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.
With the ARHGEF18 protein as a research tool, achieving meaningful scientific findings becomes an accessible and achievable goal.
The ARHGEF18 protein is a superior-quality protein that perfectly aligns with my experimental requirements.
This high-quality ARHGEF18 protein provides researchers with confidence in obtaining accurate and reliable data during their investigations
Their expertise and dedication enable them to effectively address and resolve any technical issues that may arise during experimentation.
The manufacturer's team of experts possesses a deep understanding of the ARHGEF18 protein and its associated protocols.
the ARHGEF18 protein's versatility extends beyond its use in vitro experiments.
In conclusion, using ARHGEF18 protein in trials offers distinct advantages for researchers studying cell cycle regulation.
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