Recombinant Human ARHGEF18 Protein (159-551 aa), GST-tagged ARHGEF18-1214H

Recombinant Human ARHGEF18 Protein (159-551 aa), GST-tagged

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Recombinant Human ARHGEF18 Protein (159-551 aa), GST-tagged

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Cat.No. : ARHGEF18-1214H
Product Overview : Recombinant Human ARHGEF18 Protein (159-551 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Partial.
Description : Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.
Source : E. coli
Species : Human
Tag : GST
Form : Tris-based buffer,50% glycerol
Molecular Mass : 71.5 kDa
Protein length : 159-551 aa
AA Sequence : MTVSQKGGPQPTPSP AGPGTQLGPITGEMD EADSAFLKFKQTADD SLSLTSPNTESIFVE DPYTASLRSEIESDG HEFEAESWSLAVDAA YAKKQKREVVKRQDV LYELMQTEVHHVRTL KIMLKVYSRALQEEL QFSSKAIGRLFPCAD DLLETHSHFLARLKE RRQESLEEGSDRNYV IQKIGDLLVQQFSGE NGERMKEKYGVFCSG HNEAVSHYKLLLQQN KKFQNLIKKIGNFSI VRRLGVQECILLVTQ RITKYPVLVERIIQN TEAGTEDYEDLTQAL NLIKDIISQVDAKVS ECEKGQRLREIAGKM DLKSSSKLKNGLTFR KEDMLQRQLHLEGML CWKTTSGRLKDILAI LLTDVLLLLQEKDQK YVFASVDSKPPVISL QKL
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 [ Homo sapiens ]
Official Symbol : ARHGEF18
Synonyms : ARHGEF18; KIAA0521; MGC15913; P114 RhoGEF; SA-RhoGEF; p114RhoGEF; P114-RHO-GEF; P114-RhoGEF;
Gene ID : 23370
mRNA Refseq : NM_001130955
Protein Refseq : NP_001124427
UniProt ID : Q6ZSZ5

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