ARHGEF40
-
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 40
-
Synonyms
ARHGEF40; Rho guanine nucleotide exchange factor (GEF) 40; rho guanine nucleotide exchange factor 40; FLJ10357; solo; LOC55701; protein SOLO;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ARHGEF40-626HCL | Recombinant Human ARHGEF40 cell lysate | N/A |
|
||
| Human | ARHGEF40-4836HF | Recombinant Full Length Human ARHGEF40 Protein, GST-tagged | In Vitro Cell Free System | GST | 326 amino acids |
|
| Human | ARHGEF40-4215H | Recombinant Human ARHGEF40 Protein, GST-tagged | Wheat Germ | GST |
|
|
| Mouse | ARHGEF40-1904M | Recombinant Mouse ARHGEF40 Protein | Mammalian Cell | His |
|
|
| Mouse | ARHGEF40-702M | Recombinant Mouse ARHGEF40 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
|
|
| Mouse | ARHGEF40-702M-B | Recombinant Mouse ARHGEF40 Protein Pre-coupled Magnetic Beads | HEK293 |
|
- Involved Pathway
- Protein Function
- Interacting Protein
- ARHGEF40 Related Articles
ARHGEF40 involved in several pathways and played different roles in them. We selected most pathways ARHGEF40 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ARHGEF40 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF40 itself. We selected most functions ARHGEF40 had, and list some proteins which have the same functions with ARHGEF40. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho guanyl-nucleotide exchange factor activity | ARHGEF16;KALRN;DNMBP;FGD;PLEKHG6;SOS1;ITSN2A;ARHGEF6;FGD4 |
| protein binding | BAG2;ERAL1;AMBRA1;TNFSF13B;MLLT1;MAF;LIMS1;TMEM185A;GTPBP3 |
ARHGEF40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF40 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF40.
STC2; TAC1; MYCBP
- Q&As
- Reviews
Q&As (7)
Ask a questionWhile there is limited information on diseases directly linked to ARHGEF40 dysregulation, abnormalities in Rho GTPase signaling pathways, which ARHGEF40 modulates, have been implicated in various pathological conditions. Dysregulation of Rho GTPases and their regulatory proteins can contribute to cancer progression, cardiovascular diseases, and neurological disorders, among others.
ARHGEF40 protein regulates various cellular processes, including actin cytoskeletal organization, cell migration, cell adhesion, and cell polarity. It modulates Rho GTPase activity, which in turn influences the dynamics of the actin cytoskeleton and cellular responses related to cell adhesion and movement.
The presence of mutations or genetic variations in the ARHGEF40 gene has not been extensively explored. However, genetic variations within genes encoding Rho GEFs and Rho GTPases have been implicated in several diseases. It would be interesting to investigate if any mutations or variations in the ARHGEF40 gene are associated with specific clinical phenotypes.
Targeting ARHGEF40 for therapeutic purposes is an area of ongoing investigation. Modulating the activity of ARHGEF40 or interfering with its protein-protein interactions could potentially offer therapeutic benefits, particularly in diseases involving dysregulated Rho GTPase signaling. However, further studies are needed to validate the feasibility and effectiveness of such interventions.
The specific protein interactions of ARHGEF40 are not extensively characterized. However, as a Rho GEF, it is expected to interact with Rho GTPases and potentially other downstream effectors of Rho signaling pathways. Elucidating its precise protein interactions would require further research.
While ARHGEF40 is primarily known for its role as a guanine nucleotide exchange factor for Rho GTPases, it is possible that it might interact with or influence other signaling pathways. However, research on this aspect of ARHGEF40 is limited, and further investigation would be required to fully understand its potential involvement in other signaling networks.
There is some evidence suggesting a potential role for ARHGEF40 in neuronal development and function. The Rho GTPase signaling pathways modulated by ARHGEF40 are involved in neuronal processes such as axon guidance, dendrite formation, and synaptic plasticity. Further studies are required to fully elucidate the specific involvement of ARHGEF40 in neuronal development and its impact on neurological disorders.
Customer Reviews (8)
Write a reviewIts purity, consistency, and reliable performance make it a top choice for a wide range of applications.
ARHGEF40 is a key regulator of cellular structure and function, particularly in the context of maintaining the integrity of the cell membrane and organizing cytoskeletal components.
This versatility enables researchers to explore ARHGEF40's function and role in a range of biological processes, making it a valuable tool across diverse research fields.
ARHGEF40 can be used in various experimental setups and assays, including in vitro cell culture studies, animal models, and even clinical investigations.
One advantage of using ARHGEF40 protein in trials is its versatility.
What sets the ARHGEF40 protein apart is not only its outstanding quality but also the excellent technical support provided by the manufacturer.
The ARHGEF40 protein offers exceptional quality that meets the rigorous demands of experimental research.
Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the ARHGEF40 protein is an invaluable tool for researchers.
Ask a Question for All ARHGEF40 Products
Required fields are marked with *
My Review for All ARHGEF40 Products
Required fields are marked with *
