Recombinant Human ARHGEF40 Protein, GST-tagged
Cat.No. : | ARHGEF40-4215H |
Product Overview : | Human FLJ10357 full-length ORF ( AAH00084.3, 1 a.a. - 326 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
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Description : | This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain. Alternatively spliced transcripts that encode different proteins have been described. [provided by RefSeq, Mar 2014] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 62.2 kDa |
AA Sequence : | MEAGPYLPRALQQPLEQLTRYGRLL EELLREAGPELSSECRALGAAVQLL REQEARGRDLLAVEAVRGCEIDLKE QGQLLHRDPFTVICGRKKCLRHVFL FEHLLLFSKLKGPEGGSEMFVYKQA FKTADMGLTENIGDSGLCFELWFRR RRAREAYTLQATSPEIKLKWTSSIA QLLWRQAAHNKELRVQQMVSMGIGN KPFLDIKALGERTLSALLTGRAARP RASVAVSSFEHAGPSLPGLSPGACS LPARVEEEAWDLDVKQISLAPETLD SSGDVSPGPRNSPSLQPPHPGSSTP TLASRGILGLSRQSHARALSDPTTP L |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ARHGEF40 Rho guanine nucleotide exchange factor 40 [ Homo sapiens (human) ] |
Official Symbol : | ARHGEF40 |
Synonyms : | ARHGEF40; Rho guanine nucleotide exchange factor 40; SOLO; rho guanine nucleotide exchange factor 40; Rho guanine nucleotide exchange factor (GEF) 40; protein SOLO |
Gene ID : | 55701 |
mRNA Refseq : | NM_001278529 |
Protein Refseq : | NP_001265458 |
MIM : | 610018 |
UniProt ID : | Q8TER5 |
Products Types
◆ Recombinant Protein | ||
ARHGEF40-702M | Recombinant Mouse ARHGEF40 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARHGEF40-1904M | Recombinant Mouse ARHGEF40 Protein | +Inquiry |
◆ Lysates | ||
ARHGEF40-626HCL | Recombinant Human ARHGEF40 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionWhile there is limited information on diseases directly linked to ARHGEF40 dysregulation, abnormalities in Rho GTPase signaling pathways, which ARHGEF40 modulates, have been implicated in various pathological conditions. Dysregulation of Rho GTPases and their regulatory proteins can contribute to cancer progression, cardiovascular diseases, and neurological disorders, among others.
ARHGEF40 protein regulates various cellular processes, including actin cytoskeletal organization, cell migration, cell adhesion, and cell polarity. It modulates Rho GTPase activity, which in turn influences the dynamics of the actin cytoskeleton and cellular responses related to cell adhesion and movement.
The presence of mutations or genetic variations in the ARHGEF40 gene has not been extensively explored. However, genetic variations within genes encoding Rho GEFs and Rho GTPases have been implicated in several diseases. It would be interesting to investigate if any mutations or variations in the ARHGEF40 gene are associated with specific clinical phenotypes.
Targeting ARHGEF40 for therapeutic purposes is an area of ongoing investigation. Modulating the activity of ARHGEF40 or interfering with its protein-protein interactions could potentially offer therapeutic benefits, particularly in diseases involving dysregulated Rho GTPase signaling. However, further studies are needed to validate the feasibility and effectiveness of such interventions.
The specific protein interactions of ARHGEF40 are not extensively characterized. However, as a Rho GEF, it is expected to interact with Rho GTPases and potentially other downstream effectors of Rho signaling pathways. Elucidating its precise protein interactions would require further research.
While ARHGEF40 is primarily known for its role as a guanine nucleotide exchange factor for Rho GTPases, it is possible that it might interact with or influence other signaling pathways. However, research on this aspect of ARHGEF40 is limited, and further investigation would be required to fully understand its potential involvement in other signaling networks.
There is some evidence suggesting a potential role for ARHGEF40 in neuronal development and function. The Rho GTPase signaling pathways modulated by ARHGEF40 are involved in neuronal processes such as axon guidance, dendrite formation, and synaptic plasticity. Further studies are required to fully elucidate the specific involvement of ARHGEF40 in neuronal development and its impact on neurological disorders.
Customer Reviews (8)
Write a reviewIts purity, consistency, and reliable performance make it a top choice for a wide range of applications.
ARHGEF40 is a key regulator of cellular structure and function, particularly in the context of maintaining the integrity of the cell membrane and organizing cytoskeletal components.
This versatility enables researchers to explore ARHGEF40's function and role in a range of biological processes, making it a valuable tool across diverse research fields.
ARHGEF40 can be used in various experimental setups and assays, including in vitro cell culture studies, animal models, and even clinical investigations.
One advantage of using ARHGEF40 protein in trials is its versatility.
What sets the ARHGEF40 protein apart is not only its outstanding quality but also the excellent technical support provided by the manufacturer.
The ARHGEF40 protein offers exceptional quality that meets the rigorous demands of experimental research.
Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the ARHGEF40 protein is an invaluable tool for researchers.
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