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Recombinant Human ARHGEF40 Protein, GST-tagged

Cat.No. : ARHGEF40-4215H
Product Overview : Human FLJ10357 full-length ORF ( AAH00084.3, 1 a.a. - 326 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain. Alternatively spliced transcripts that encode different proteins have been described. [provided by RefSeq, Mar 2014]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 62.2 kDa
AA Sequence : MEAGPYLPRALQQPLEQLTRYGRLL EELLREAGPELSSECRALGAAVQLL REQEARGRDLLAVEAVRGCEIDLKE QGQLLHRDPFTVICGRKKCLRHVFL FEHLLLFSKLKGPEGGSEMFVYKQA FKTADMGLTENIGDSGLCFELWFRR RRAREAYTLQATSPEIKLKWTSSIA QLLWRQAAHNKELRVQQMVSMGIGN KPFLDIKALGERTLSALLTGRAARP RASVAVSSFEHAGPSLPGLSPGACS LPARVEEEAWDLDVKQISLAPETLD SSGDVSPGPRNSPSLQPPHPGSSTP TLASRGILGLSRQSHARALSDPTTP L
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ARHGEF40 Rho guanine nucleotide exchange factor 40 [ Homo sapiens (human) ]
Official Symbol : ARHGEF40
Synonyms : ARHGEF40; Rho guanine nucleotide exchange factor 40; SOLO; rho guanine nucleotide exchange factor 40; Rho guanine nucleotide exchange factor (GEF) 40; protein SOLO
Gene ID : 55701
mRNA Refseq : NM_001278529
Protein Refseq : NP_001265458
MIM : 610018
UniProt ID : Q8TER5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there any diseases associated with dysregulation of ARHGEF40 protein? 07/21/2022

While there is limited information on diseases directly linked to ARHGEF40 dysregulation, abnormalities in Rho GTPase signaling pathways, which ARHGEF40 modulates, have been implicated in various pathological conditions. Dysregulation of Rho GTPases and their regulatory proteins can contribute to cancer progression, cardiovascular diseases, and neurological disorders, among others.

What cellular processes does ARHGEF40 protein regulate? 03/23/2022

ARHGEF40 protein regulates various cellular processes, including actin cytoskeletal organization, cell migration, cell adhesion, and cell polarity. It modulates Rho GTPase activity, which in turn influences the dynamics of the actin cytoskeleton and cellular responses related to cell adhesion and movement.

Are there any known mutations or genetic variations in the ARHGEF40 gene? 11/01/2020

The presence of mutations or genetic variations in the ARHGEF40 gene has not been extensively explored. However, genetic variations within genes encoding Rho GEFs and Rho GTPases have been implicated in several diseases. It would be interesting to investigate if any mutations or variations in the ARHGEF40 gene are associated with specific clinical phenotypes.

Can ARHGEF40 be targeted for therapeutic purposes? 01/13/2020

Targeting ARHGEF40 for therapeutic purposes is an area of ongoing investigation. Modulating the activity of ARHGEF40 or interfering with its protein-protein interactions could potentially offer therapeutic benefits, particularly in diseases involving dysregulated Rho GTPase signaling. However, further studies are needed to validate the feasibility and effectiveness of such interventions.

Are there any known protein interactions with ARHGEF40? 03/26/2018

The specific protein interactions of ARHGEF40 are not extensively characterized. However, as a Rho GEF, it is expected to interact with Rho GTPases and potentially other downstream effectors of Rho signaling pathways. Elucidating its precise protein interactions would require further research.

Is ARHGEF40 involved in any signaling pathways apart from Rho GTPases? 08/29/2017

While ARHGEF40 is primarily known for its role as a guanine nucleotide exchange factor for Rho GTPases, it is possible that it might interact with or influence other signaling pathways. However, research on this aspect of ARHGEF40 is limited, and further investigation would be required to fully understand its potential involvement in other signaling networks.

Does ARHGEF40 play a role in neuronal development or function? 07/28/2017

There is some evidence suggesting a potential role for ARHGEF40 in neuronal development and function. The Rho GTPase signaling pathways modulated by ARHGEF40 are involved in neuronal processes such as axon guidance, dendrite formation, and synaptic plasticity. Further studies are required to fully elucidate the specific involvement of ARHGEF40 in neuronal development and its impact on neurological disorders.

Customer Reviews (8)

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Reviews
03/27/2023

    Its purity, consistency, and reliable performance make it a top choice for a wide range of applications.

    06/22/2022

      ARHGEF40 is a key regulator of cellular structure and function, particularly in the context of maintaining the integrity of the cell membrane and organizing cytoskeletal components.

      01/30/2022

        This versatility enables researchers to explore ARHGEF40's function and role in a range of biological processes, making it a valuable tool across diverse research fields.

        12/10/2021

          ARHGEF40 can be used in various experimental setups and assays, including in vitro cell culture studies, animal models, and even clinical investigations.

          07/14/2019

            One advantage of using ARHGEF40 protein in trials is its versatility.

            11/12/2018

              What sets the ARHGEF40 protein apart is not only its outstanding quality but also the excellent technical support provided by the manufacturer.

              03/07/2018

                The ARHGEF40 protein offers exceptional quality that meets the rigorous demands of experimental research.

                10/19/2017

                  Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the ARHGEF40 protein is an invaluable tool for researchers.

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