ARHGEF9
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Official Full Name
Cdc42 guanine nucleotide exchange factor (GEF) 9 -
Overview
The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010] -
Synonyms
ARHGEF9;Cdc42 guanine nucleotide exchange factor (GEF) 9;PEM2;EIEE8;PEM-2;HPEM-2;COLLYBISTIN;rho guanine nucleotide exchange factor 9;PEM-2 homolog;hPEM-2 collybistin;rac/Cdc42 guanine nucleotide exchange factor 9
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
ARHGEF9 involved in several pathways and played different roles in them. We selected most pathways ARHGEF9 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GABA A receptor activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NRAGE signals death through JNK | FGD4A,ARHGEF1A,OBSCN,FGD2,FGD4,PLEKHG2,ABR,ARHGEF3,ARHGAP4,ARHGEF16 |
| G alpha (12/13) signalling events | FGD4A,OBSCN,TIAM2,ARHGEF18A,NET1,ECT2,ITSN1,KALRNB,ARHGEF1A,ARHGAP4A |
| GPCR downstream signaling | EDNRA,GPR68,FGD2,ANXA1A,GRP,EDN1,CHRM1,DGKB,AMCF-II,KALRN |
| Cell death signalling via NRAGE, NRIF and NADE | AATF,ARHGAP4,ABR,KALRNB,ECT2,AKAP13,KALRN,NET1,TRIO,ITSN1 |
| Ligand-gated ion channel transport | GLRBA,GABRR2A,HTR3C |
| Ion channel transport | TTYH3,CCC2,CUTC,TCIRG1,TRPC4A,BEST4,CLCN5,CLCN4-2,ATP1A1A.4,TRPC4APB |
| GABA receptor activation | KCNJ10,GNGT2A,GNGT2B,KCNJ2A,GABRR2A,KCNJ2,KCNJ12,KCNJ9,KCNJ15,KCNJ4 |
Protein Function
ARHGEF9 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF9 itself. We selected most functions ARHGEF9 had, and list some proteins which have the same functions with ARHGEF9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho guanyl-nucleotide exchange factor activity | ARHGEF19,NET1,FGD4,ARHGEF2,ARHGEF37,ARHGEF1B,ARHGEF1A,FGD3,DOCK10,KALRNB |
Interacting Protein
ARHGEF9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF9 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF9.
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References
- Kusuhara, S; Fukushima, Y; et al. Arhgef15 Promotes Retinal Angiogenesis by Mediating VEGF-Induced Cdc42 Activation and Potentiating RhoJ Inactivation in Endothelial Cells. PLOS ONE 7:-(2012).
- Guo, F; Xing, Y; et al. GUANINE-NUCLEOTIDE EXCHANGE FACTOR H1 MEDIATES LIPOPOLYSACCHARIDE-INDUCED INTERLEUKIN 6 AND TUMOR NECROSIS FACTOR alpha EXPRESSION IN ENDOTHELIAL CELLS VIA ACTIVATION OF NUCLEAR FACTOR kappa B. SHOCK 37:531-538(2012).
