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ARIH1

  • Official Full Name

    ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1

  • Overview

    Protein ariadne-1 homolog is a protein that in humans is encoded by the ARIH1 gene.
  • Synonyms

    ARIH1; ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila); ariadne (Drosophila) homolog, ubiquitin conjugating enzyme E2 binding protein, 1; E3 ubiquitin-protein ligase ARIH1; ARI; ariadne; Drosophila; homolog of; HARI; HHARI;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARIH1-799H Recombinant Human ARIH1 protein, GST-tagged Wheat Germ GST
Human ARIH1-8726HCL Recombinant Human ARIH1 293 Cell Lysate HEK293 N/A
Human ARIH1-4007H Recombinant Human ARIH1 protein, His-tagged E.coli His 209-507 aa
Human ARIH1-1175HF Recombinant Full Length Human ARIH1 Protein, GST-tagged In Vitro Cell Free System GST 557 amino acids
Mouse ARIH1-1918M Recombinant Mouse ARIH1 Protein Mammalian Cell His
Mouse ARIH1-713M-B Recombinant Mouse ARIH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ARIH1-713M Recombinant Mouse ARIH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ARIH1-10147Z Recombinant Zebrafish ARIH1 Mammalian Cell His
Chicken ARIH1-2246C Recombinant Chicken ARIH1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARIH1 involved in several pathways and played different roles in them. We selected most pathways ARIH1 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARIH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Antiviral mechanism by IFN-stimulated genesEIF4G2A;EIF4EB;KPNA5;IFIT10;EIF4E3;HERC5;EIF4A1;IFIT11;KPNA4
Cytokine Signaling in Immune systemTRIM68;KPNA4;EIF4E;UBE2L6;LAMTOR2;FCGR1B;FRS2;IRAK3;PAQR3A
ISG15 antiviral mechanismEIF4G2A;EIF4G2;IFIT12;MX2;ARIH1L;UBE2L6;HERC5;ARIH1;KPNA3
Immune SystemKIR3DS1;FCN1;Mill2;RAP1GAP2B;LTN1;IRF4;SH3RF1;PANX1A;PVRL2L
Interferon SignalingGBP5;GBP2;FCGR1B;HLA-DQB2;ARIH1L;EIF4G2A;TRIM31;IFIT8;GBP4

ARIH1 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin conjugating enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARIH1 itself. We selected most functions ARIH1 had, and list some proteins which have the same functions with ARIH1. You can find most of the proteins on our site.

Function Related Protein
ligase activityBTR22;MIB2;TRIML2;GLULB;RNF180;CBLC;TRIM69;MKRN1;WWP1
protein bindingSTX4A;CIB3;SIRT4;CD80;MOXD1;CABP1;DPM1;MAPRE3;ZSCAN21
ubiquitin conjugating enzyme bindingDCUN1D1;DCUN1D2B;TRIM72;ARIH1;TRAF6;DCUN1D2A;PPARA;RNF144AB;RASD2
ubiquitin protein ligase activityRNF14;PDZD4;ANKIB1;BTRC;RNF144AA;HERC6;G2E3;HECTD3;UBE2C
ubiquitin protein ligase bindingJKAMP;ANAPC2;CUL5A;GPR19;UBE2G1;FLJ11011L;SMAD6;CXCR4;H2-AB1
ubiquitin-like protein transferase activityATG16L1;RNF14;ARIH1;UBL4A;ATG3;RNF139
ubiquitin-protein transferase activityRNF181;UBR3;FBXO30A;WWP2;FBXO25;CDC23;TRIM71;ZNRF3;TRIM62
zinc ion bindingMYLIPB;RNF26;AGBL3;GLO1;RERE;ZDHHC18A;MT1G;LHX5;ZFML

ARIH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARIH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARIH1.

CUL1; FBXW11; HSPB1; VAV2; CCNE1; CDKN1B; UBE2L3; CUL2; CUL3; CUL4A

  • Q&As
  • Reviews

Q&As (12)

Ask a question
Are there any known functional domains or motifs within the ARIH1 protein structure? 12/17/2022

Yes, the ARIH1 protein contains several functional domains, including an N-terminal RBR (RING-between-RING) domain, which is responsible for its E3 ubiquitin ligase activity. It also has a central coiled-coil domain and a C-terminal region that contributes to its protein-protein interactions. These domains collectively contribute to the diverse functions of the ARIH1 protein.

Are there any known interacting proteins or cofactors of the ARIH1 protein? 06/14/2022

Yes, the ARIH1 protein interacts with various proteins and cofactors to carry out its functions. Some known interacting proteins include BRCA1, TRAF6, and UbcH7. These interactions play a role in modulating ARIH1 activity and its involvement in different cellular pathways.

How is the ARIH1 protein involved in innate immune signaling? 09/15/2021

The ARIH1 protein is known to play a role in innate immune signaling by regulating the activation of the NF-κB pathway. It interacts with and promotes the ubiquitination and degradation of proteins involved in NF-κB signaling, thereby controlling the immune response.

Are there any diseases associated with ARIH1 dysfunction? 08/01/2020

Yes, mutations in the ARIH1 gene have been associated with a rare autosomal recessive disorder known as autoinflammation with arthritis and dyskeratosis (AIADK). This condition is characterized by recurrent fever episodes, arthritis, and other systemic symptoms.

Does the ARIH1 protein have any role in neurodegenerative diseases? 05/24/2020

The involvement of the ARIH1 protein in neurodegenerative diseases is still an area of ongoing research. Some studies suggest that dysregulation of ARIH1 may contribute to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease. However, more research is needed to fully understand its role in these conditions.

Are there any drugs targeting the ARIH1 protein? 04/30/2020

Currently, there are no specific drugs that directly target the ARIH1 protein. However, understanding its role in disease pathways may help identify potential therapeutic strategies indirectly targeting ARIH1-associated conditions.

Are there any cellular pathways or molecular processes where the ARIH1 protein is still being studied? 03/05/2020

The ARIH1 protein is actively being studied in several areas of research. Some ongoing areas of investigation include its role in cancer development and progression, its involvement in cellular stress responses, and its impact on protein homeostasis. Further research is needed to fully understand its contributions in these contexts.

Does the ARIH1 protein have any role in mitochondrial quality control? 08/08/2017

Yes, the ARIH1 protein has been found to be involved in mitochondrial quality control. It helps in the removal of damaged or dysfunctional mitochondria through a process called mitophagy, ensuring the maintenance of cellular homeostasis.

How is the ARIH1 protein linked to autoinflammation with arthritis and dyskeratosis (AIADK)? 05/18/2017

Mutations in the ARIH1 gene have been associated with AIADK, a rare autosomal recessive disorder. These mutations lead to the loss of ARIH1 function, resulting in dysregulation of immune responses and inflammatory manifestations seen in AIADK patients.

Is the ARIH1 protein involved in DNA damage repair? 02/09/2017

Yes, studies suggest that the ARIH1 protein is involved in DNA damage repair pathways. It interacts with other proteins involved in DNA repair, such as BRCA1, and contributes to the maintenance of genomic stability.

Can ARIH1 gene mutations be inherited and passed on to future generations? 08/15/2016

Yes, mutations in the ARIH1 gene can be inherited in an autosomal recessive manner. This means that an individual must inherit two copies of the mutated gene, one from each parent, in order to develop the associated disorder or condition.

How does the ARIH1 protein contribute to protein degradation? 07/16/2016

ARIH1 functions as an E3 ubiquitin ligase, which means it catalyzes the transfer of ubiquitin molecules onto target proteins. This process marks the proteins for degradation by the proteasome, a cellular recycling machinery.

Customer Reviews (8)

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Reviews
11/11/2022

    Extensive research has been conducted on ARIH1, making it relatively accessible and well-understood in terms of its structure and functions.

    05/18/2022

      The manufacturer's excellent technical support, commitment to innovation, and customer-centric approach further reinforce its suitability for my research.

      02/12/2022

        The manufacturer's commitment to providing exceptional technical support ensures that I will receive valuable assistance when facing challenges in my research.

        12/06/2020

          They actively engage with researchers, comprehending their specific experimental needs, and offering tailored services accordingly.

          08/21/2020

            Their knowledgeable team is readily available to address any concerns or difficulties I may encounter during my experiments. With their expertise, I can confidently overcome any obstacles and achieve optimal results.

            07/04/2019

              the ARIH1 protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

              12/11/2018

                With their support, I can confidently explore the intricacies of ARIH1 and make significant contributions to the understanding of its functions in various biological processes.

                07/04/2017

                  Its versatility allows for its effective utilization in a broad range of studies, including molecular biology, cellular assays, and protein interactions analysis.

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