Does ARMC2 protein have any regulatory role in cellular processes?
Yes, ARMC2 protein plays a regulatory role in microtubule dynamics and organization. It contributes to the stability and proper assembly of the centrosome, thereby influencing cell division and intracellular transport.
Does the expression of ARMC2 protein vary in different tissues or developmental stages?
Yes, the expression of ARMC2 protein is known to be tissue-specific and may vary during different developmental stages, suggesting its importance in specific cellular contexts.
Where is ARMC2 protein localized within the cell?
ARMC2 protein is predominantly localized in the centrosome, which is a crucial organelle involved in cell division and microtubule organization.
Can ARMC2 protein modulate cell motility or cell adhesion?
ARMC2 protein's role in cell motility or adhesion has not been extensively studied. Further investigation is required to understand its potential involvement in these processes.
Has the functional domain architecture of ARMC2 protein been elucidated?
Yes, ARMC2 protein contains multiple ARM (Armadillo repeat) domains, which are involved in protein-protein interactions and are crucial for its functions in microtubule organization and regulation.
Are there any known disease associations or mutations in ARMC2 protein?
Mutations in the ARMC2 gene have been associated with primary ciliary dyskinesia (PCD), a genetic disorder affecting the structure and function of cilia in respiratory and reproductive systems.
Are there any known interacting partners of ARMC2 protein?
Yes, ARMC2 protein interacts with several proteins involved in microtubule organization and centrosome function, including PCM1, CEP76, and PCM1L1.
Is ARMC2 protein conserved across different species?
Yes, ARMC2 protein is highly conserved across various species, indicating its fundamental role in cellular processes.