ARSG
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Official Full Name
arylsulfatase G
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Overview
Sulfatases, such as ARSG, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This gene, a novel arylsulfatase, has activity toward pseudosubstrates including p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. Activity is competitively inhibited by phosphate. The unprocessed protein is active as a 63-kDa monomer and demonstrates an acidic pH optimum as typically seen for lysosomal sulfatases. The protein accumulates within lysosomes and is also a glycoprotein that binds specifically to mannose 6-phosphate receptors. -
Synonyms
ARSG; arylsulfatase G; KIAA1001; ARSG_HUMAN; Arylsulfatase G precursor; ASG; PRO1777; UNQ839;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- CHO
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ARSG Related Articles
- ARSG Related Research Area
ARSG involved in several pathways and played different roles in them. We selected most pathways ARSG participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARSG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | CTSL1B;ACP2;ATP6AP1;AP3B2;Abca2;LAMP2;CTSC;CTSO;CTSM |
ARSG has several biochemical functions, for example, arylsulfatase activity, NOT arylsulfatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARSG itself. We selected most functions ARSG had, and list some proteins which have the same functions with ARSG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arylsulfatase activity | ARSD;ARSG;ARSA;SULF1;ARSE;SULF2;ARSI;ARSH;ARSJ |
| NOT arylsulfatase activity | |
| metal ion binding | PPM1L;ZNF658;FBXO5;RHOU;ZZEF1;ZFP422;WBSCR17;CYP2AD2;TRERF1 |
ARSG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARSG here. Most of them are supplied by our site. Hope this information will be useful for your research of ARSG.
- Q&As
- Reviews
Q&As (6)
Ask a questionCurrently, there are no known diseases directly associated with mutations in the ARSG gene. Further research is needed to determine if any mutations in this gene can cause specific health conditions.
Currently, there are no therapeutic strategies directly targeting ARSG due to limited knowledge of its function and disease associations. However, further research on its role in sulfated molecule metabolism may identify potential therapeutic applications in the future.
There is limited scientific evidence linking ARSG to cancer. However, some studies have indicated its altered expression in certain cancer types, suggesting a potential association. Further research is necessary to understand the significance of ARSG in cancer development and progression.
The specific interacting proteins or pathways associated with ARSG are currently not well-established. Further research is required to understand its potential interactions and pathways in cellular processes.
Yes, genetic variations or single nucleotide polymorphisms (SNPs) have been identified in the ARSG gene. These variations may have implications for protein function, but their exact significance and impact on health are not yet fully understood.
While research on the ARSG protein is limited, ongoing studies aim to elucidate its biological function, substrate specificity, and potential roles in various cellular processes. Additionally, investigations may focus on understanding the consequences of ARSG mutations and exploring therapeutic strategies for related diseases, if any are identified in the future.
Customer Reviews (3)
Write a reviewIts superior purity and stability ensure reliable and reproducible results, providing me with confidence in the integrity of my experiments.
Whether I am investigating protein-protein interactions, studying enzymatic activity, or conducting protein structure analyses, the ARSG protein consistently delivers exceptional performance and accurate results.
The ARSG protein is an exceptional product that meets the highest standards of quality, making it an ideal choice to fulfill my experimental requirements.
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