|Official Full Name||ankyrin repeat and SOCS box containing 2|
|Background||This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.|
|Synonyms||ASB2; ankyrin repeat and SOCS box containing 2; ankyrin repeat and SOCS box protein 2; ASB 2; ankyrin repeat and SOCS box-containing protein 2a; ASB-2; MGC40044|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
asb2 involved in several pathways and played different roles in them. We selected most pathways asb2 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with asb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Adaptive Immune System||CMTM2A; AP1G1; CTSO; Mill2; MKRN1; RASGRP1; RAP1GAP2; CD300A; RAPGEF4; FRS2|
|Antigen processing: Ubiquitination &||TRIM39; UBE2U; LRSAM1; ASB8; PJA2; ASB4; TRIM69; STUB1; RBCK1; ASB18|
|Proteasome degradation||UBR2; UBE2J2; SPSB4; RNF182; TRIM39; RNF19B; HUWE1; BLMH; ASB17; ASB2|
|Class I MHC mediated antigen processing &||UBE2V1; UBR2; HECTD3; ERAP1; LRR1; CTSL1; FBXO17; CTSS; SEC23A; TRIM39|
|presentation||GAN; ATG7; FCGR1B; TPP2; ASB13; RNF19B; ASB9; ASB8; ASB7; SPSB1|
|Immune System||RNF182; ARIH2; LILRA1; ERAP2; KIF11; DEFB116; B2ML; KIF22; KIR3DS1; GM11711|
asb2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by asb2 itself. We selected most functions asb2 had, and list some proteins which have the same functions with asb2. You can find most of the proteins on our site.
|protein binding||EIF2B2; RPS3; MINOS1; PRRC1; KIF21A; PLAU; ADCK3; PHF8; RRM2; INTS9|
asb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with asb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of asb2.
HSP90AB1; CUL5; RNF7; SMAD9; ESR2