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Official Full Name ankyrin repeat and SOCS box containing 2
Background This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms ASB2; ankyrin repeat and SOCS box containing 2; ankyrin repeat and SOCS box protein 2; ASB 2; ankyrin repeat and SOCS box-containing protein 2a; ASB-2; MGC40044
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ASB2-40HCL Recombinant Human ASB2 lysate HEK293 N/A
    Human ASB2-891H Recombinant Human ASB2 protein, GST-tagged Wheat Germ GST
    Mouse ASB2-2014M Recombinant Mouse ASB2 Protein Mammalian Cell His
    Rat ASB2-817R Recombinant Rat ASB2 Protein Mammalian Cell His

    asb2 involved in several pathways and played different roles in them. We selected most pathways asb2 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with asb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System CMTM2A; AP1G1; CTSO; Mill2; MKRN1; RASGRP1; RAP1GAP2; CD300A; RAPGEF4; FRS2
    Antigen processing: Ubiquitination &amp TRIM39; UBE2U; LRSAM1; ASB8; PJA2; ASB4; TRIM69; STUB1; RBCK1; ASB18
    Proteasome degradation UBR2; UBE2J2; SPSB4; RNF182; TRIM39; RNF19B; HUWE1; BLMH; ASB17; ASB2
    Class I MHC mediated antigen processing &amp UBE2V1; UBR2; HECTD3; ERAP1; LRR1; CTSL1; FBXO17; CTSS; SEC23A; TRIM39
    presentation GAN; ATG7; FCGR1B; TPP2; ASB13; RNF19B; ASB9; ASB8; ASB7; SPSB1
    Immune System RNF182; ARIH2; LILRA1; ERAP2; KIF11; DEFB116; B2ML; KIF22; KIR3DS1; GM11711

    asb2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by asb2 itself. We selected most functions asb2 had, and list some proteins which have the same functions with asb2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding EIF2B2; RPS3; MINOS1; PRRC1; KIF21A; PLAU; ADCK3; PHF8; RRM2; INTS9

    asb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with asb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of asb2.

    HSP90AB1; CUL5; RNF7; SMAD9; ESR2

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