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Recombinant Human ASB2 protein, GST-tagged

Cat.No. : ASB2-891H
Product Overview : Human ASB2 full-length ORF ( AAH32354, 1 a.a. - 587 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 90.31 kDa
AA Sequence : MTRFSYAEYFSLFHSCSAPSRSTAP PESSPARAPMGSFQGVMQKYSSSLF KTSQLAPADPLIKAIKDGDEEALKT MIKEGKNLAEPNKEGWLPLHEAAYY GQVGCLKVLQRAYPGTIDQRTLQEE TAVYLATCRGHLDCLLSLLQAGAEP DISNKSRETPLYKACERKNAEAVKI LVQHNADTNHRCNRGWTALHESVSR NDLEVMQILVSGGAKVESKNAYGIT PLFVAAQSGQLEALRFLAKYGADIN TQASDNASALYEACKNEHEEVVEFL LSQGADANKTNKDGLLPLHIASKKG NYRIVQMLLPVTSRTRIRRSGVSPL HLAAERNHDEVLEALLSARFDVNTP LAPERARLYEDRRSSALYFAVVNNN VYATELLLQHGADPNRDVISPLLVA IRHGCLRTMQLLLDHGANIDAYIAT HPTAFPATIMFAMKCLSLLKFLMDL GCDGEPCFSCLYGNGPHPPAPQPSS RFNDAPAADKEPSVVQFCEFVSAPE VSRWAGPIIDVLLDYVGNVQLCSRL KEHIDSFEDWAVIKEKAEPPRPLAH LCRLRVRKAIGKYRIKLLDTLPLPG RLIRYLKYENTQ
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ASB2 ankyrin repeat and SOCS box containing 2 [ Homo sapiens ]
Official Symbol : ASB2
Synonyms : ASB2; ankyrin repeat and SOCS box containing 2; ankyrin repeat and SOCS box protein 2; ASB 2; ankyrin repeat and SOCS box-containing protein 2a; ASB-2; MGC40044;
Gene ID : 51676
mRNA Refseq : NM_001202429
Protein Refseq : NP_001189358
MIM : 605759
UniProt ID : Q96Q27

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is ASB2 involved in any specific cellular pathways or processes? 08/10/2022

The ASB2 protein is believed to be involved in cellular processes like protein degradation and the regulation of immune responses, but the specific pathways are still being studied.

Does ASB2 have any known substrates for protein degradation? 06/06/2020

The specific substrates targeted by ASB2 for protein degradation have not been fully identified yet.

Are there any known small molecules or drugs that can modulate ASB2 activity? 03/26/2020

Currently, there are no known small molecules or drugs that specifically regulate ASB2 activity. Research in this area is ongoing.

Are there any known interactions of the ASB2 protein with other proteins? 03/03/2020

Yes, the ASB2 protein has been reported to interact with specific proteins involved in cellular signaling pathways and protein degradation mechanisms.

Can mutations in the ASB2 gene lead to any disorders? 05/18/2019

The potential role of ASB2 gene mutations in disorders is not well-established. Further research is required to understand any disease associations.

Customer Reviews (3)

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Reviews
05/04/2020

    Highly recommended for its exceptional performance in ELISA, the ASB2 protein is a top contender for researchers involved in protein electron microscopy structure analysis.

    01/20/2019

      Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.

      01/02/2019

        Coupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the ASB2 protein in their studies, knowing that they have the necessary resources and assistance to succeed.

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