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Official Full Name aspartate beta-hydroxylase
Background This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.
Synonyms ASPH; aspartate beta-hydroxylase; aspartyl/asparaginyl beta-hydroxylase; BAH; CASQ2BP1; HAAH; humbug; JCTN; junctate; junctin; ASP beta hydroxylase; Aspartyl/asparaginyl beta hydroxylase; Peptide aspartate beta dioxygenase; A beta H-J-J; cardiac junctin; ASP beta-hydroxylase; peptide-aspartate beta-dioxygenase; aspartyl/asparaginyl-beta-hydroxylase; AAH
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ASPH-1940H Recombinant Human Aspartate beta-hydroxylase, His-tagged E.coli His
    Human ASPH-27059TH Recombinant Human ASPH, His-tagged E.coli His
    Human ASPH-396H Recombinant Human ASPH Protein, His-tagged E.coli His
    Human ASPH-4503H Recombinant Human ASPH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ASPH-4988H Recombinant Human ASPH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ASPH-6093H Recombinant Human ASPH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ASPH-8643HCL Recombinant Human ASPH 293 Cell Lysate HEK293 N/A
    Human ASPH-8644HCL Recombinant Human ASPH 293 Cell Lysate HEK293 N/A
    Human ASPH-8645HCL Recombinant Human ASPH 293 Cell Lysate HEK293 N/A
    Human ASPH-917H Recombinant Human ASPH protein, GST-tagged Wheat Germ GST
    Human ASPH-9940H Recombinant Human ASPH, GST-tagged E.coli GST
    Mouse Asph-1749M Recombinant Mouse Asph Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Zebrafish ASPH-8165Z Recombinant Zebrafish ASPH Mammalian Cell His

    asph involved in several pathways and played different roles in them. We selected most pathways asph participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with asph were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport TRPC4B; ATP2B1B; ATP2C1; TRPC5A; TCIRG1; ANO8; TRPM4C; NHEDC1; MCOLN2; ATP1A1A.5
    Stimuli-sensing channels TRPM4A; TRPC4APA; TRPM1; TRPV3; ASIC1A; TPCN1; CLCN4; ANO5; SLC9B2; CLCN4-2
    Transmembrane transport of small molecules ATP2B1B; SLC6A20; SLC28A3; SLC6A1A; TRPC5; NIPAL3; CLCN2; SLC5A2; SLC43A2A; SLC20A1A

    asph has several biochemical functions, for example, calcium ion binding, electron carrier activity, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by asph itself. We selected most functions asph had, and list some proteins which have the same functions with asph. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding EFCC1; SGCA; PLA2G4A; CA; SYT1B; SULF2A; HEG; RYR3; FSTL1; CRB2A
    electron carrier activity CYP1A2; UGDH; ACADS; AKR1C4; GCDHB; AOX3; NDUFS1; DHDH; IDO1; ACADL
    ion channel binding PACS1A; RYR2; SLC8A1; PHPT1; VDAC1; LYN; DLG1; NOS1; PACS2; FYN
    peptide-aspartate beta-dioxygenase activity ASPH
    protein binding TAC3; HOMER3; TET2; CLDN2; GRAP2; RAB4B; GZMM; CAND2; POLI; IGF2BP3
    structural constituent of muscle ANKRD2; DAG1; MYLPF; TPM1; MYBPH; NEBL; MYL9; SYNM; CAPN3; DMD
    structural molecule activity COPG; KRT31; RLN3B; SEPT4; NGS; KRT23; CAV1; CLDN12; FGB; PGM5

    asph has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with asph here. Most of them are supplied by our site. Hope this information will be useful for your research of asph.

    ASNA1; HTT; SQSTM1; PDGFRL; ssrna_ug; IQCB1; P; MAP1LC3A

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