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ATM

  • Official Full Name

    ataxia telangiectasia mutated

  • Overview

    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle;checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins,;including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA;repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell;cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
  • Synonyms

    ATM; ataxia telangiectasia mutated; ATA, ataxia telangiectasia mutated (includes complementation groups A, C and D) , ATC, ATD, ATDC; serine-protein kinase ATM; TEL1; telomere maintenance 1; homolog (S. cerevisiae); TELO1; AT mutated; A-T mutated; TEL1,;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cell line
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATM-848H Recombinant Human ATM Mammalian Cell His
Human ATM-6852H Recombinant Human ATM protein, His & GST-tagged E.coli His/GST Val2484~Arg2748 (Accession # Q13315)
Human ATM-9987H Recombinant Human ATM, GST-tagged E.coli GST 1332-1479a.a.
Human ATM-185H Recombinant Human ATM protein, GST-tagged Insect Cell GST
Human ATM-953H Recombinant Human ATM protein, GST-tagged Wheat Germ GST
Human ATM-0624H Recombinant Human ATM Protein (Met1-Arg110), N-His-tagged E.coli N-His Met1-Arg110
Human ATM-1531HF Recombinant Full Length Human ATM Protein, GST-tagged In Vitro Cell Free System GST 138 amino acids
Human ATM-186H Active Recombinant Human ATM Protein (Full Length), Flag-tagged Mammalian cell line Flag
Human ATM-2514H Recombinant Human ATM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ATM-2514H-B Recombinant Human ATM Protein Pre-coupled Magnetic Beads HEK293
Mouse Atm-6853M Recombinant Mouse Atm protein, His & T7-tagged E.coli His/T7 Ile486~Ser742 (Accession # Q62388)
Mouse ATM-2094M Recombinant Mouse ATM Protein Mammalian Cell His
Mouse ATM-834M-B Recombinant Mouse ATM Protein Pre-coupled Magnetic Beads HEK293
Mouse ATM-834M Recombinant Mouse ATM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ATM-3968C Recombinant Chicken ATM Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATM Related Articles
  • ATM Related Signal Pathway

ATM involved in several pathways and played different roles in them. We selected most pathways ATM participated on our site, such as NF-kappa B signaling pathway, FoxO signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayMYD88;CCL21B;RELB;TRAF6;LRDD;ICAM1;IL1B;CCL4L1;TICAM2
FoxO signaling pathwayCDKN1BB;RAF1B;GADD45B;G6PC;NLK1;MAP2K1;GABARAP;BCL6A;PIK3R1
Cell cycleRBL1;RBBP8;GSK3B;SMAD3A;E2F2;FZR1;DMC1;NSL1;NCAPD2
p signaling pathwaySTEAP3;BIDA;SERPINE1;APAF1;GADD45AA;TP53I3;PIDD1;CCNE1;EI24
ApoptosisPRKACBA;DSG3;TNFRSF10C;CASP3A;PIK3CG;PRKACAA;BIRC8;BAD;BCL2L1
HTLV-I infectionWNT7B;H2-AA;POLD1;ITGAL;APC2;TGFB1;APC;MRAS;RB1
Transcriptional misregulation in cancerRXRB;TMPRSS2;HOXA10;PAX8;RXRA;PAX7;FOXO1;ZBTB17;LYL1
MicroRNAs in cancerFOXP1;ZFPM2;CDC25B;ST14;RPS6KA5;NOTCH1;RHOA;SLC7A1;APC2

ATM has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, ATP binding, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATM itself. We selected most functions ATM had, and list some proteins which have the same functions with ATM. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol-3-kinase activityPIK3C2B;PIK3CB;PIK3CG;PIK3R3;PIK3C2A;ATM;PIK3C2G;PIK3CD;PIK3C3
ATP bindingEP400;SRC;ATP8B5;PDPK1B;AURKA;FYNB;AARS2;RPS6KAL;UBA7
DNA bindingGPBP1L1;ZFP37;H2AFX;VEPH1;POLD2;ZFP865;HIST1H2AI;ZFP580;ZFP692
DNA-dependent protein kinase activityATM;ALPK2;HMGA2;PRKDC;XRCC6BP1
histone serine kinase activityPRKAA1;AURKB;AURKC;AURKA;PRKAA2;ATM
protein N-terminus bindingPIAS3;SLC6A3;TRAF6;ERCC3;EXOC4;UNC13A;TBL1XR1;PARP1;ERCC4
protein bindingLOC149950;AVPR2;FOXJ2;AIFM1;POLR2L;DNAJB2;CBL;MEI4;AGT
protein complex bindingCDK5RAP1;PPFIA2;CPS1;ADRB2;ERCC6;DRD1A;CDH2;ERCC8;LCK
protein dimerization activityTAL2;MESPBA;DBI;POLR2J2;NEUROD6B;HER15.1;CLOCK;NEUROD4;FBXW11
protein serine/threonine kinase activityCSNK1G2B;ULK1;DCKL1B;CSNK1E;MAPKAPK5;CAMK2G1;SGK2;STK32C;MARK4

ATM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATM here. Most of them are supplied by our site. Hope this information will be useful for your research of ATM.

TELO2; TERF1; TTI1; NABP2; ATMIN

Zhang, YQ; Jiang, CL; et al. Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8:751-757(2015).
Liu, H; Yang, WF; et al. Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair. ONCOTARGETS AND THERAPY 8:509-518(2015).
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