ATP4A

  • Official Full Name

    ATPase, H+/K+ exchanging, alpha polypeptide

  • Synonyms

    ATP4A;ATPase, H+/K+ exchanging, alpha polypeptide;819;ENSG00000105675;ATP6A;19q13.1;potassium-transporting ATPase alpha chain 1;potassium-transporting ATPase alpha chain 1;proton pump;H(+)-K(+)-ATPase alpha subunit;gastric H,K-ATPase alpha subunit;gastric hydrogen-potassium ATPase;gastric H+/K+ ATPase alpha subunit;gastric H,K-ATPase catalytic subunit;gastric H(+)/K(+) ATPase subunit alpha;ATPase, H+/K+ transporting, alpha polypeptide;EC 3.6.3.10;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Wheat Germ
  • His
  • His|GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP4a-3765H Recombinant Human ATP4a, His-tagged E.coli His 1035
Human ATP4A-19H Recombinant Human ATP4A protein, His-tagged E.coli His
Human ATP4A-975H Recombinant Human ATP4A protein Wheat Germ N/A
Human ATP4A-8608HCL Recombinant Human ATP4A 293 Cell Lysate HEK293 N/A
Human ATP4A-1297HF Recombinant Full Length Human ATP4A Protein In Vitro Cell Free System 1035 amino acids
Human ATP4A-465H Recombinant Human ATP4A Protein, His-tagged E.coli His Leu798~Gly896
Mouse Atp4a-20M Recombinant Mouse Atp4a protein, His/GST-tagged E.coli His/GST
Mouse Atp4a-466M Recombinant Mouse Atp4a Protein, His/GST-tagged E.coli His/GST Pro786~Cys1014
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATP4A Related Articles

ATP4A involved in several pathways and played different roles in them. We selected most pathways ATP4A participated on our site, such as Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationCOX8C;COX11;COX7B2;COX6A2;NDUFC2-KCTD14;ATP6V1E1;NDUFA1;NDUFB9;ATP6V1A
Collecting duct acid secretionATP6V1G1;CLCNKB;ATP4B;ATP6V0D2;SLC12A7;CA2;ATP6V1E1;TCIRG1;ATP6V0C
Gastric acid secretionKCNE2;KCNK10;CAMK2D;HRH2;SST;KCNK2;KCNJ10;CALML5;KCNJ1

ATP4A has several biochemical functions, for example, ATP binding, hydrogen:potassium-exchanging ATPase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP4A itself. We selected most functions ATP4A had, and list some proteins which have the same functions with ATP4A. You can find most of the proteins on our site.

Function Related Protein
ATP bindingERN1;CAMK1G;CDK8;FAM20B;YARS;TOR1;Abcb1b;ATAD1B;KIAA1804
hydrogen:potassium-exchanging ATPase activityATP6V1E1B;ATP12A;ATP4A;ATP4B
magnesium ion bindingNUAK2;HPRT1;PRPSAP1;DOM3Z;TSSK1;NT5C1AA;PRTFDC1;ITPK1;CDC42BPB
protein heterodimerization activityHIST1H2AF;TLR2;SOX6;SOX14;CEBPB;POLA1;PDGFA;CABYR;CRLF1
sodium:potassium-exchanging ATPase activityATP1A3B;ATP1B3;ATP1A1A.3;ATP1A3A;FXYD2;ATP1A1B;ATP1A1;ATP1A1A.1;ATP12A

ATP4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP4A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP4A.

Matsui, MS; Petris, MJ; et al. Omeprazole, a Gastric Proton Pump Inhibitor, Inhibits Melanogenesis by Blocking ATP7A Trafficking. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:834-841(2015).
Chobot, A; Wenzlau, J; et al. ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 177:598-602(2014).
  • Q&As
  • Reviews

Q&As (6)

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Is the polymorphism of Atp4a gene associated with abnormal gastric acid? 04/20/2021

Yes, polymorphic variations in the Atp4a gene may be associated with the susceptibility and pathogenesis of gastric acid abnormalities, such as hyperacidity or hypoacidity.

Does Atp4a interact with proteins? 03/09/2021

Atp4a interacts with other proteins in the Parietal cells of the gastric mucosa, such as parietal cell-associated proteins, to jointly regulate gastric acid production and secretion.

What is the mutation mechanism of Atp4a? 10/26/2020

Mutations in Atp4a may lead to abnormal changes in its intracellular localization and function, and then affect the normal secretion of gastric acid.

How does Atp4a function under estrogen regulation? 11/14/2019

Atp4a may be regulated by estrogen and regulate gastric acid secretion by affecting Atp4a expression and activity.

Which is the regulatory mechanism of Atp4a in gastric acid secretion? 11/06/2019

Regulates gastric acid secretion through ATP binding and ion pump transport, and the specific mechanism involves the regulation of multiple signaling pathways and hormones.

What are the structural features of Atp4a? 08/18/2019

Atp4a is a plasma wall protein containing several membrane channels and ATP-binding sites that regulate gastric acid secretion.

Customer Reviews (3)

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Reviews
03/01/2022

    After using Atp4a, the background of the Western blot was very clean with no nonspecific signal.

    03/22/2020

      I appreciate the stability of Atp4a, which can be kept at room temperature for several days without deterioration.

      07/04/2019

        By using Atp4a, the precision of my experiments was significantly improved and the results were more reliable.

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