ATP4A
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Official Full Name
ATPase, H+/K+ exchanging, alpha polypeptide
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Synonyms
ATP4A;ATPase, H+/K+ exchanging, alpha polypeptide;819;ENSG00000105675;ATP6A;19q13.1;potassium-transporting ATPase alpha chain 1;potassium-transporting ATPase alpha chain 1;proton pump;H(+)-K(+)-ATPase alpha subunit;gastric H,K-ATPase alpha subunit;gastric hydrogen-potassium ATPase;gastric H+/K+ ATPase alpha subunit;gastric H,K-ATPase catalytic subunit;gastric H(+)/K(+) ATPase subunit alpha;ATPase, H+/K+ transporting, alpha polypeptide;EC 3.6.3.10;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- E.coli
- HEK293
- In Vitro Cell Free System
- Wheat Germ
- His
- GST
- N
- C
- Myc
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ATP4a-3765H | Recombinant Human ATP4a, His-tagged | E.coli | His | 1035 |
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| Human | ATP4A-19H | Recombinant Human ATP4A protein, His-tagged | E.coli | His | ||
| Human | ATP4A-975H | Recombinant Human ATP4A protein | Wheat Germ | Non |
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| Human | ATP4A-8608HCL | Recombinant Human ATP4A 293 Cell Lysate | HEK293 | Non |
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| Human | ATP4A-1297HF | Recombinant Full Length Human ATP4A Protein | In Vitro Cell Free System | 1035 amino acids |
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| Human | ATP4A-465H | Recombinant Human ATP4A Protein, His-tagged | E.coli | His | Leu798~Gly896 | |
| Human | ATP4A-3343H | Recombinant Human ATP4A protein, His&Myc-tagged | E.coli | N-His&C-Myc | 350-783aa |
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| Mouse | Atp4a-20M | Recombinant Mouse Atp4a protein, His/GST-tagged | E.coli | His&GST | ||
| Mouse | Atp4a-466M | Recombinant Mouse Atp4a Protein, His/GST-tagged | E.coli | His&GST | Pro786~Cys1014 |
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ATP4A involved in several pathways and played different roles in them. We selected most pathways ATP4A participated on our site, such as Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | MT-ND4;NDUFS8B;ATP6V0E2;NDUFB11;ATP5I;ATP6V1BA;COX6B2;mt-Atp8;ATP5A1 |
| Collecting duct acid secretion | ATP6V1E2;Car2;ATP6V1B2;ATP6V0E;CA2;TCIRG1;ATP6V0A2;SLC12A7;ATP6V0D1 |
| Gastric acid secretion | ACTB;ATP4B;PRKACA;HRH2;CA2;CCKBR;Adcy4;ATP1B4;CALM1 |
ATP4A has several biochemical functions, for example, ATP binding, hydrogen:potassium-exchanging ATPase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP4A itself. We selected most functions ATP4A had, and list some proteins which have the same functions with ATP4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | BLM;NLRP12;OASL2;KIF12;KALRN;ATP2B1;MAP3K15;KIF27;MSH4 |
| hydrogen:potassium-exchanging ATPase activity | ATP4A;ATP4B;ATP12A;ATP6V1E1B |
| magnesium ion binding | PGM3;ENO3;HPGDS;TSSK2;PRTFDC1;FEN1;FAN1;CIB2;ATP11C |
| protein heterodimerization activity | CHRNB2;BMP6;HIST1H2AG;ENO3;CUL5;GAD2;TXLNG;TAF13;BAXA |
| sodium:potassium-exchanging ATPase activity | ATP1A4;ATP1A3B;ATP1A3A;ATP1A1A.3;FXYD2;ATP1A2A;ATP1A1A.5;ATP1A1A.1;ATP1A3 |
ATP4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP4A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP4A.
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewAfter using Atp4a, the background of the Western blot was very clean with no nonspecific signal.
I appreciate the stability of Atp4a, which can be kept at room temperature for several days without deterioration.
By using Atp4a, the precision of my experiments was significantly improved and the results were more reliable.
Q&As (6)
Ask a questionYes, polymorphic variations in the Atp4a gene may be associated with the susceptibility and pathogenesis of gastric acid abnormalities, such as hyperacidity or hypoacidity.
Atp4a interacts with other proteins in the Parietal cells of the gastric mucosa, such as parietal cell-associated proteins, to jointly regulate gastric acid production and secretion.
Mutations in Atp4a may lead to abnormal changes in its intracellular localization and function, and then affect the normal secretion of gastric acid.
Atp4a may be regulated by estrogen and regulate gastric acid secretion by affecting Atp4a expression and activity.
Regulates gastric acid secretion through ATP binding and ion pump transport, and the specific mechanism involves the regulation of multiple signaling pathways and hormones.
Atp4a is a plasma wall protein containing several membrane channels and ATP-binding sites that regulate gastric acid secretion.
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