ATP5D
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Official Full Name
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
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Overview
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. -
Synonyms
ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit; ATP synthase subunit delta, mitochondrial; F-ATPase delta subunit; mitochondrial ATP synthase, delta subunit; mitochondrial ATP synthase complex delta-subunit precusor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian Cell
- Yeast
- GST
- His
- His (Fc)
- Avi
- Myc
- SUMO
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ATP5D involved in several pathways and played different roles in them. We selected most pathways ATP5D participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP5D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | NDUFB8;UQCRC2A;COX4I2;NDUFS2;NDUFA5;ATP5A1;ATP6V1F;NDUFS3;ATP5C1 |
| Metabolic pathways | ACSM5;GALM;NDUFV2;CKMT1;MECR;MAN1A;AMDHD1;SC5D;TK1 |
| Alzheimers disease | CALM3;LRP1;NDUFAB1;NDUFA6;NDUFA1;PPP3R2;IDE;UQCRFS1;ATP2A3 |
| Parkinsons disease | ATP5G3;UBE2J2;HTRA2;UQCRQ;SDHD;NDUFB10;ATP5F1;NDUFA4L2;ATP5B |
| Huntingtons disease | SDHA;COX7B2;SOD1;NDUFB9;TAF4B;COX6A2;NDUFS5;UQCRQ;NDUFV2 |
ATP5D has several biochemical functions, for example, contributes_to ADP binding, contributes_to ATP binding, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP5D itself. We selected most functions ATP5D had, and list some proteins which have the same functions with ATP5D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ADP binding | MSH2;MSH6;ATP5D |
| contributes_to ATP binding | MSH2;ATP5D;ATP1A2;ABCG8;MSH6;SFRP5;ATP1B1 |
| contributes_to ATPase activity | ATP5J2;MSH6;ATP5B;RFC3;ATP5A1;PPP2R4;ATP5L;ABCA7;ATP1B1 |
| contributes_to proton-transporting ATP synthase activity, rotational mechanism | ATP5D;ATP5F1 |
| proton-transporting ATPase activity, rotational mechanism | ATP6V0A1B;ATP6V1AA;ATP6V1B2;ATP5B;ATP5D;ATP6V0A1A;ATP6V1H;ATP6V0A1;ATP5A1 |
| transmembrane transporter activity | SLC2A15B;SLC22A13;SLC2A15A;ATP5A1;SLC2A11L;SLCO1D1;ATP5H;ATP5J2;SLC2A11B |
| transporter activity | CLVS2;CLVS1;ABCA6;CRABP2A;SLC17A9;ABCF2;AP1B1;SLC22A1;KIF20A |
ATP5D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP5D here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP5D.
vpu; SGK1; RIPK2; EIF1B; ATP5F1; PSMD6; ATG5; TTN; FRMD3; ssrna_ug; Kcnk1; BLK; Atp5a1; P; SLC38A1
- Q&As
- Reviews
Q&As (6)
Ask a questionATP5D may serve as a potential therapeutic target in some neurological and metabolic diseases.
Yes, mutations in the ATP5D gene are associated with certain neurological diseases such as multiple sclerosis, Parkinson's disease, etc.
ATP5D protein may be related to the occurrence and progression of metabolic diseases such as obesity and diabetes.
It may play a role in tumor cell metabolism and energy supply.
ATP5D is a subunit of the F1 portion of the mitochondrial ATP synthase complex involved in mitochondrial energy production.
The expression and function of ATP5D are affected by a variety of regulatory mechanisms, including regulation of transcription factors and epigenetic modifications.
Customer Reviews (3)
Write a reviewBecause the remarkable purity of ATP5D makes it a valuable tool for sensitive and accurate experiments.
The remarkable repeatability of ATP5D makes it an invaluable tool for accurate and reproducible experiments.
The protein's purity and consistency make it a top choice for Western-blot experiments.
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