• Official Full Name

    ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 [ Homo sapiens ]

  • Overview

    The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome.
  • Synonyms

    a2; A2V ATPase; ARCL; ATP6a2; ATP6N1D; ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a isoform 2; ATPase, H+ transporting, lysosomal V0 subunit a2; Infantile malignant osteopetrosis; J6B7; Lysosomal H(+) transporting ATPase V0 subunit a2; Lysosomal H(+)-transporting ATPase V0 subunit a2; Stv1; TJ6; TJ6M; TJ6s; V ATPase 116 kDa isoform a2; V type proton ATPase 116 kDa subunit a; V type proton ATPase 116 kDa subunit a isoform 2; V-ATPase 116 kDa isoform a2; V-type proton ATPase 116 kDa subunit a isoform 2; Vacuolar proton translocating ATPase 116 kDa subunit a; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; Vph1; VPP2_HUMAN; WSS;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V0A2-10034H Recombinant Human ATP, His-tagged E.coli His 3-372a.a.
Human ATP6V0A2-995H Recombinant Human ATP6V0A2 protein, GST-tagged Wheat Germ GST
Human ATP6V0A2-1168HF Recombinant Full Length Human ATP6V0A2 Protein, GST-tagged In Vitro Cell Free System GST 372 amino acids
Mouse ATP6V0A2-2150M Recombinant Mouse ATP6V0A2 Protein Mammalian Cell His
Mouse ATP6V0A2-870M-B Recombinant Mouse ATP6V0A2 Protein Pre-coupled Magnetic Beads HEK293
Mouse ATP6V0A2-870M Recombinant Mouse ATP6V0A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ATP6V0A2-6288C Recombinant Chicken ATP6V0A2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ATP6V0A2 involved in several pathways and played different roles in them. We selected most pathways ATP6V0A2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationATP6V1E1;COX7A3;COX17;ATP5I;ATP6V1B1;SDHC;NDUFAB1A;NDUFS8B;NDUFB9
Metabolic pathwaysHSD17B12A;XYLB;ST8SIA1;HSD17B10;ETNK2;DHRS4;ATP5A1;POLD4;IDH3B
Synaptic vesicle cycleATP6V1B1;CPLX3;VAMP2;ATP6V1B2;ATP6V1H;STX1A;UNC13C;CPLX4;NAPA
Collecting duct acid secretionATP6V1G2;ATP6V0E;ATP6V1C1;ATP6V1G3;ATP6V0E2;ATP6V0A4;Car2;ATP6V1A;ATP4A
Vibrio cholerae infectionKDELR1;GNAS;ATP6V1E1;PLCG1;ATP6V1F;PRKACA;ATP6V0E1;ATP6V0D1;TJP1
Epithelial cell signaling in Helicobacter pylori infectionCXCR2;NFKBIA;PLCG2;ATP6V1C2;SRC;TCIRG1;MAPK13;ATP6V1G3;ATP6AP1

ATP6V0A2 has several biochemical functions, for example, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0A2 itself. We selected most functions ATP6V0A2 had, and list some proteins which have the same functions with ATP6V0A2. You can find most of the proteins on our site.

Function Related Protein
protein bindingRAD9A;MBD4;FGD2;ENOX1;TNFAIP8L2;F11R;BCLAF1;CCDC108;PHF7
proton-transporting ATPase activity, rotational mechanismATPV0E2;ATP6V0CB;ATP6V1AA;ATP6V0E2;ATP6V1C1;ATP6V0A1B;ATP6V0C;ATP6V1H;ATP6V1E1

ATP6V0A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0A2.

CYTH2; b3xyc5_sollc; Rock1; REEP5

Research Area

Related articles

Jang, HM; Erf, GF; et al. Genome resequencing and bioinformatic analysis of SNP containing candidate genes in the autoimmune vitiligo Smyth line chicken model. BMC GENOMICS 15:-(2014).
Gardeitchik, T; Mohamed, M; et al. Clinical and biochemical features guiding the diagnostics in neurometabolic cutis laxa. EUROPEAN JOURNAL OF HUMAN GENETICS 22:888-895(2014).
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