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ATP6V0A2

Official Full Name

ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 [ Homo sapiens ]
Background

The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome.
Synonyms

a2; A2V ATPase; ARCL; ATP6a2; ATP6N1D; ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a isoform 2; ATPase, H+ transporting, lysosomal V0 subunit a2; Infantile malignant osteopetrosis; J6B7; Lysosomal H(+) transporting ATPase V0 subunit a2; Lysosomal H(+)-transporting ATPase V0 subunit a2; Stv1; TJ6; TJ6M; TJ6s; V ATPase 116 kDa isoform a2; V type proton ATPase 116 kDa subunit a; V type proton ATPase 116 kDa subunit a isoform 2; V-ATPase 116 kDa isoform a2; V-type proton ATPase 116 kDa subunit a isoform 2; Vacuolar proton translocating ATPase 116 kDa subunit a; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; Vph1; VPP2_HUMAN; WSS;

Type:
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species :
Chicken
Human
Mouse

Source :
E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag :
GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Chicken	ATP6V0A2-6288C	Recombinant Chicken ATP6V0A2	Mammalian Cell	His	Inquiry
Human	ATP6V0A2-10034H	Recombinant Human ATP, His-tagged	E.coli	His	$319.00 / 25ug
Human	ATP6V0A2-995H	Recombinant Human ATP6V0A2 protein, GST-tagged	Wheat Germ	GST	Inquiry
Mouse	ATP6V0A2-2150M	Recombinant Mouse ATP6V0A2 Protein	Mammalian Cell	His	Inquiry
Mouse	ATP6V0A2-870M-B	Recombinant Mouse ATP6V0A2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	ATP6V0A2-870M	Recombinant Mouse ATP6V0A2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug

Involved Pathway
Protein Function
Interacting Protein
ATP6V0A2 Related Articles

ATP6V0A2 involved in several pathways and played different roles in them. We selected most pathways ATP6V0A2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	ATP6V0A1;NDUFB11;ATP6V0A1A;ATP4B;MT-ND4;NDUFB4;ATP6V1G1;ATP6V0E2;NDUFA3
Metabolic pathways	NDUFA5;ATP5I;GK2;TKTB;PDHB;LCLAT1;CEPT1B;ASMT;SDHD
Lysosome	ATP6V0CB;PLA2G15;GUSB;GGA2;LAPTM5;ATP6V0A2;SMPD1;GBA;SUMF1
Phagosome	ATP6V1AA;BLA;DYNC1I2A;NOX1;ITGA2;ATP6V1E2;TUBA4A;MSR1;FCGR3A
Synaptic vesicle cycle	NAPA;ATP6V1D;ATP6V0D1;ATP6V1C1;SLC17A6;SLC17A8;ATP6V1A;SYT1;ATP6V1B1
Collecting duct acid secretion	ATP6V1G1;ATP6V0A4;ATP6V1C2;ATP6V0A2;CA2;ATP6V1C1;ATP6V1E2;ATP6V0D1;ATP6V1B2
Vibrio cholerae infection	KDELR1;TJP1;SEC61G;TJP2;ATP6V0E1;PRKACG;ATP6V1E1;ATP6V1G1;ATP6V1F
Epithelial cell signaling in Helicobacter pylori infection	JAM2;ATP6V0C;ATP6V1G2;ATP6AP1;MET;ATP6V0E1;ATP6V0A4;ATP6V1B2;ATP6V1D
Tuberculosis	PMAP-36;NOS2;MAPK11;H2-AA;TGFB3;IFNA16;IFNA4;CAP18;TLR2
Rheumatoid arthritis	IL6;TGFB1;HLA-DPA1;ATP6V1F;HLA-DQA1;CXCL1;Il23a;ATP6V0E1;CCL5

ATP6V0A2 has several biochemical functions, for example, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0A2 itself. We selected most functions ATP6V0A2 had, and list some proteins which have the same functions with ATP6V0A2. You can find most of the proteins on our site.

Function	Related Protein
ATPase binding	ATXN3;TAF9;ALDOB;ATP6V0A1B;ATP6V0A1;SNTA1;NSFL1C;ATPIF1B;NUFIP1
protein binding	NOP56;MSH3;SOCS7;RHO;GDF5;DAZAP2;COPRS;MTNR1A;TOPORS
proton-transporting ATPase activity, rotational mechanism	ATP6V0E1;ATP6V0A2;ATPV0E2;ATP6V1B2;ATP6V1C1;ATP6V0CA;ATP6V0A4;ATP5A1;ATP6V0A1A

ATP6V0A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0A2.

CYTH2; b3xyc5_sollc; Rock1; REEP5

Jang, HM; Erf, GF; et al. Genome resequencing and bioinformatic analysis of SNP containing candidate genes in the autoimmune vitiligo Smyth line chicken model. BMC GENOMICS 15:-(2014).

Gardeitchik, T; Mohamed, M; et al. Clinical and biochemical features guiding the diagnostics in neurometabolic cutis laxa. EUROPEAN JOURNAL OF HUMAN GENETICS 22:888-895(2014).