Creative BioMart to Present at BPS 2025 Annual Meeting | February 15-19, 2025 Learn More

ATP6V0A2

Official Full Name

ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 [ Homo sapiens ]
Overview

The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome.
Synonyms

a2; A2V ATPase; ARCL; ATP6a2; ATP6N1D; ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a isoform 2; ATPase, H+ transporting, lysosomal V0 subunit a2; Infantile malignant osteopetrosis; J6B7; Lysosomal H(+) transporting ATPase V0 subunit a2; Lysosomal H(+)-transporting ATPase V0 subunit a2; Stv1; TJ6; TJ6M; TJ6s; V ATPase 116 kDa isoform a2; V type proton ATPase 116 kDa subunit a; V type proton ATPase 116 kDa subunit a isoform 2; V-ATPase 116 kDa isoform a2; V-type proton ATPase 116 kDa subunit a isoform 2; Vacuolar proton translocating ATPase 116 kDa subunit a; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; Vph1; VPP2_HUMAN; WSS;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ATP6V0A2-10034H	Recombinant Human ATP, His-tagged	E.coli	His	3-372a.a.	$319 / 25μg
Human	ATP6V0A2-995H	Recombinant Human ATP6V0A2 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ATP6V0A2-1168HF	Recombinant Full Length Human ATP6V0A2 Protein, GST-tagged	In Vitro Cell Free System	GST	372 amino acids	Inquiry
Mouse	ATP6V0A2-2150M	Recombinant Mouse ATP6V0A2 Protein	Mammalian Cell	His		Inquiry
Mouse	ATP6V0A2-870M-B	Recombinant Mouse ATP6V0A2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	ATP6V0A2-870M	Recombinant Mouse ATP6V0A2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Chicken	ATP6V0A2-6288C	Recombinant Chicken ATP6V0A2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

ATP6V0A2 involved in several pathways and played different roles in them. We selected most pathways ATP6V0A2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	ATP6V1C1;ATP6V0A1;ATP5J;UQCRB;UQCR11;ATP6V1F;ATP6V1G2;NDUFS7;ATP6AP1B
Metabolic pathways	PEMT;PPAP2D;HSD17B3;CYP2C37;OCRL;CDO1;FH1;COX7B2;PIK3C2G
Lysosome	ATP6V0A2;AP1G2;GNSA;ATP6V0A1;AP1M3;AP4B1;ATP6AP1;ATP6V0A4;SORT1B
Phagosome	ITGB3B;ACTB1;RAB5C;ATP6V1H;ATP6V1A;Cd209g;ATP6V1G2;HLA-F;CALR
Synaptic vesicle cycle	ATP6V1H;ATP6V0B;ATP6V0A2;SLC18A2;RAB3A;NSF;ATP6V0E2;SNAP25;ATP6V0A4
Collecting duct acid secretion	CLCNKB;ATP6V1E2;ATP6V0C;ATP6V1B2;ATP6V0A4;ATP6V0E;ATP6V1E1;ATP6V0D2;SLC4A1
Vibrio cholerae infection	ATP6V0D1;ATP6V0D2;ATP6AP1;ATP6V1E2;ATP6V0A1;GNAS;ERO1L;ATP6V1C2;ATP6V1A
Epithelial cell signaling in Helicobacter pylori infection	MET;RAC1;IL-8;ATP6V0A4;ATP6V1B1;PAK1;JAM3;NFKBIA;ATP6V1E2
Tuberculosis	IFNGR1;IL18;ATP6V0D2;MAPK9;ATP6V0A2;Il23a;CAMK2B;CALM1;IFNA5
Rheumatoid arthritis	ICAM1;HLA-DOB;ATP6AP1;HLA-DPB1;ATP6V1H;CXCL6;TNF;HLA-DQA1;ITGAL

ATP6V0A2 has several biochemical functions, for example, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0A2 itself. We selected most functions ATP6V0A2 had, and list some proteins which have the same functions with ATP6V0A2. You can find most of the proteins on our site.

Function	Related Protein
ATPase binding	PLN;DNAJC10;CHRNA7;SLC26A9;TCIRG1;ATP6V0A2B;ANK2;NHP2L1;Ar
protein binding	SYT4;BOLL;RTN4R;BTF3;CANX;FAM122A;LARP4B;NHEJ1;ATP2A2
proton-transporting ATPase activity, rotational mechanism	ATP5A1;ATP6V0E1;ATP6V0A4;ATP6V0E2;ATP6V0C;ATP6V1B2;ATP6V0A2;ATP6V1F;ATP6V0A1B

ATP6V0A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0A2.

CYTH2; b3xyc5_sollc; Rock1; REEP5

Research Area

Jang, HM; Erf, GF; et al. Genome resequencing and bioinformatic analysis of SNP containing candidate genes in the autoimmune vitiligo Smyth line chicken model. BMC GENOMICS 15:-(2014).

Gardeitchik, T; Mohamed, M; et al. Clinical and biochemical features guiding the diagnostics in neurometabolic cutis laxa. EUROPEAN JOURNAL OF HUMAN GENETICS 22:888-895(2014).