Recombinant Human ATP, His-tagged

• Cat.No.: ATP6V0A2-10034H
• Product Overview: Recombinant Human ATPHis-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 3-372a.a.
• Description: The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 [ Homo sapiens ]
• Official Symbol: ATP6V0A2
• Synonyms: a2; A2V ATPase; ARCL; ATP6a2; ATP6N1D; ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a isoform 2; ATPase, H+ transporting, lysosomal V0 subunit a2; Infantile malignant osteopetrosis; J6B7; Lysosomal H(+) transporting ATPase V0 subunit a2; Lysosomal H(+)-transporting ATPase V0 subunit a2; Stv1; TJ6; TJ6M; TJ6s; V ATPase 116 kDa isoform a2; V type proton ATPase 116 kDa subunit a; V type proton ATPase 116 kDa subunit a isoform 2; V-ATPase 116 kDa isoform a2; V-type proton ATPase 116 kDa subunit a isoform 2; Vacuolar proton translocating ATPase 116 kDa subunit a; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; Vph1; VPP2_HUMAN; WSS; ATP6V0A2
• Gene ID: 23545
• mRNA Refseq: NM_012463.3
• Protein Refseq: NP_036595.2
• MIM: 611716
• UniProt ID: Q9Y487
• Chromosome Location: 12q24.31
• Pathway: Collecting duct acid secretion, organism-specific biosystem; Collecting duct acid secretion, conserved biosystem; Disease, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem; Insulin receptor recycling, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem
• Function: hydrogen ion transmembrane transporter activity; protein binding