ATP6V0A4

  • Official Full Name

    ATPase, H+ transporting, lysosomal V0 subunit a4

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
  • Synonyms

    ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4; ATP6N1B, ATP6N2, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non catalytic accessory protein 1B , ATPase, H+ transporting, lysosomal V0 subunit a isoform 4 , ATPase, H+ transport;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V0A4-746H Recombinant Human ATP6V0A4 Mammalian Cell His
Human ATP6V0A4-2992H Recombinant Human ATP6V0A4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ATP6V0A4-2520H Recombinant Human ATP6V0A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ATP6V0A4-6451H Recombinant Human ATP6V0A4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ATP6V0A4-2520H-B Recombinant Human ATP6V0A4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Atp6v0a4-989M Recombinant Mouse Atp6v0a4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Chicken ATP6V0A4-3599C Recombinant Chicken ATP6V0A4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATP6V0A4 Related Articles

ATP6V0A4 involved in several pathways and played different roles in them. We selected most pathways ATP6V0A4 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationNDUFS8B;NDUFAB1A;ATP6V0A1;NDUFS5;NDUFB11;ATP6V0CA;ATP5C1;COX6A2;ATP6V1C1B
Metabolic pathwaysHEXB;ATP6V0E1;B3GNT5A;STT3A;FUT8A;MIBP;NT5C2B;AKR1C4;AK2
LysosomeCTSA;CTSLA;PPT2;NAGLU;AP1M1;AP3B1;GAA;PLA2G15;HYAL1
PhagosomeTUBA8L4;CD209A;SEC22B;RAC1;ITGB2L;Ctsl;MARCO;PIKFYVE;ITGB3B
Synaptic vesicle cycleDNM3;ATP6V1D;ATP6V1H;SLC17A6;NAPA;STX3;ATP6V1E1;ATP6V0A4;ATP6V0E2
Collecting duct acid secretionATP6V1B1;ATP6V0E2;ATP6V1B2;ATP6V0D2;ATP6V0E1;ATP6V1C2;ATP6V0A1;ATP6V1C1;ATP4B
Vibrio cholerae infectionPLCG1;KDELR3;ATP6V0D2;ATP6V0A2;ATP6AP1;ATP6V0A4;ATP6V1E2;TJP2;ATP6V1C1
Epithelial cell signaling in Helicobacter pylori infectionATP6V1F;ATP6V0A1;NFKB1;CXCL1;ATP6V0A2;F11R;ATP6V1C1;JAM3;PLCG2
TuberculosisIl23a;Ifna15;IL1B;CALML3;AKT1;ATP6V0A1;TGFB2;TGFB3;MAPK3
Rheumatoid arthritisTLR2;ATP6V0D1;TEK;TNF;TNFRSF11A;FLT1;Ccl12;HLA-DPB1;IL18

ATP6V0A4 has several biochemical functions, for example, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0A4 itself. We selected most functions ATP6V0A4 had, and list some proteins which have the same functions with ATP6V0A4. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingATP6V1G3;FXYD4;Ar;TAF9;ESR1;NHP2L1;PEX26;ATP6V0A2;ATP6V0A4
protein bindingMPHOSPH8;RPGRIP1;MCM5;ZNF143;DNAJB9;GMNN;GRIK5;RYR1B;DNM1
proton-transporting ATPase activity, rotational mechanismATP6AP1;ATP6V1F;ATP6V1E1;ATP6V1A;ATP6V0C;ATP6V0CB;ATP6V1C1;ATP6V0A1;ATP6V1AA

ATP6V0A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0A4.

Nagara, M; Voskarides, K; et al. A novel splice-site mutation in ATP6V0A4 gene in two brothers with distal renal tubular acidosis from a consanguineous Tunisian family. JOURNAL OF GENETICS 93:859-863(2014).
Zeinali, F; Mohseni, M; et al. Investigation of ATP6V1B1 and ATP6V0A4 genes causing hereditary hearing loss associated with distal renal tubular acidosis in Iranian families. JOURNAL OF LARYNGOLOGY AND OTOLOGY 128:1056-1059(2014).
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