Home / Products / atp6v0a4


Official Full Name ATPase, H+ transporting, lysosomal V0 subunit a4
Background This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
Synonyms ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4; ATP6N1B, ATP6N2, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non catalytic accessory protein 1B , ATPase, H+ transporting, lysosomal V0 subunit a isoform 4 , ATPase, H+ transport
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • MYC/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP6V0A4-2992H Recombinant Human ATP6V0A4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ATP6V0A4-6451H Recombinant Human ATP6V0A4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ATP6V0A4-746H Recombinant Human ATP6V0A4 Mammalian Cell His
    Mouse Atp6v0a4-989M Recombinant Mouse Atp6v0a4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Chicken ATP6V0A4-3599C Recombinant Chicken ATP6V0A4 Mammalian Cell His

    atp6v0a4 involved in several pathways and played different roles in them. We selected most pathways atp6v0a4 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with atp6v0a4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation NDUFA4L; ATP5D; COX15; COX7A2L; MT-ND4; NDUFA2; NDUFA4; NDUFB3; ATP5A1; UQCRH
    Metabolic pathways HADHAA; PLA2G4AA; RDH8A; AGPAT4; COX6B2; PYGL; ST6GALNAC3; ALDH4A1; PFKP; LPIN1
    Phagosome TLR2-2; TUBA4L; ITGB1; C3A.2; TUBA3C; HLA-DQB1; NCF1; TUBA3B; MHC1UEA; TLR4BB
    Synaptic vesicle cycle UNC13C; ATP6V0E2; STX1A; ATP6V1E1; ATP6V0D1; NSF; ATP6V1H; CPLX3; ATP6V1G1; CPLX4
    Collecting duct acid secretion ATP6V0D1; CA2; ATP6V0A4; ATP6V1G2; ATP6V1F; ATP6V0A2; ATP6V1G1; SLC12A7; SLC4A1; TCIRG1
    Vibrio cholerae infection PRKACB; KDELR3; TJP1; MUC2; ATP6V0A1; ACTB; ATP6V1D; ATP6V0D2; ATP6V1E1; ATP6V0B
    Epithelial cell signaling in Helicobacter pylori infection PLCG2; MAPK8; ATP6V1D; CDC42; F11R; NFKB1; TJP1; RELA; IKBKG; ATP6V1A
    Tuberculosis CYCS; HLA-DRB4; CAMK2G; RAB7; PIK3C3; RAB7A; IFNA7; SRC; FADD; NFKB1
    Rheumatoid arthritis ATP6AP1; MMP1A; HLA-DRA; HLA-DQA2; FLT1; FOS; LTB; IL11; CTLA4; HLA-DOA

    atp6v0a4 has several biochemical functions, for example, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by atp6v0a4 itself. We selected most functions atp6v0a4 had, and list some proteins which have the same functions with atp6v0a4. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding S100A1; ESR1; RAB4A; PDE4D; ATPIF1A; ATPIF1B; FBL; PEX26; METTL21A; ATP6V0A2
    protein binding RAB22A; CAST; NFKBIL1; LILRB3; ARID5A; HDAC7; RIMS1; IRF2BP1; PDCD1; ZNF576
    proton-transporting ATPase activity, rotational mechanism ATP6V0C; ATP6V1B2; ATP6V0A2; ATP6V1F; ATP6V0CA; ATP5B; ATP5E; ATP6V1C1; ATP6V1H; ATP6V0E

    atp6v0a4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with atp6v0a4 here. Most of them are supplied by our site. Hope this information will be useful for your research of atp6v0a4.

    Nagara, M; Voskarides, K; et al. A novel splice-site mutation in ATP6V0A4 gene in two brothers with distal renal tubular acidosis from a consanguineous Tunisian family. JOURNAL OF GENETICS 93:859-863(2014).
    Zeinali, F; Mohseni, M; et al. Investigation of ATP6V1B1 and ATP6V0A4 genes causing hereditary hearing loss associated with distal renal tubular acidosis in Iranian families. JOURNAL OF LARYNGOLOGY AND OTOLOGY 128:1056-1059(2014).

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy