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ATP6V0A4

Official Full Name

ATPase, H+ transporting, lysosomal V0 subunit a4
Overview

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
Synonyms

ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4; ATP6N1B, ATP6N2, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non catalytic accessory protein 1B , ATPase, H+ transporting, lysosomal V0 subunit a isoform 4 , ATPase, H+ transport;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
MYC
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	ATP6V0A4-746H	Recombinant Human ATP6V0A4	Mammalian Cell	His	Inquiry
Human	ATP6V0A4-2992H	Recombinant Human ATP6V0A4 Protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Human	ATP6V0A4-2520H	Recombinant Human ATP6V0A4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Human	ATP6V0A4-6451H	Recombinant Human ATP6V0A4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Human	ATP6V0A4-2520H-B	Recombinant Human ATP6V0A4 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	Atp6v0a4-989M	Recombinant Mouse Atp6v0a4 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK	Inquiry
Chicken	ATP6V0A4-3599C	Recombinant Chicken ATP6V0A4	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

ATP6V0A4 involved in several pathways and played different roles in them. We selected most pathways ATP6V0A4 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	COX5A;ATP5B;ATP6AP1B;ATP6V1E2;NDUFA3;ctaG;ATP6V0A4;ATP5G3B;NDUFA6
Metabolic pathways	PNP;GAD2;NDUFB9;NDST1;DLDH;PCYT1AA;ALG11;HDC;DPM1
Lysosome	ACP5;CTSM;SORT1B;LGMN;ATP6V0B;ATP6V0A1;ATP6V0C;SLC17A5;SLC11A1
Phagosome	ATP6V0A1A;C3A.2;THBS4B;CANX;CTSSB.2;HLA-G;RAB7;VAMP3;TUBA2
Synaptic vesicle cycle	ATP6V0D1;ATP6V1F;ATP6V0A2;CPLX4;RAB3A;ATP6V1E1;NAPA;ATP6V0E;UNC13A
Collecting duct acid secretion	ATP6V0D2;ATP6V0A2;ATP6V1E1;ATP6V1D;ATP4A;SLC4A1;ATP6V0E;ATP6V1G3;TCIRG1
Vibrio cholerae infection	ATP6AP1;ATP6V1C2;PLCG2;KDELR1;ATP6V0A4;ATP6V1E1;ATP6V1H;ATP6V0A1;KDELR3
Epithelial cell signaling in Helicobacter pylori infection	ATP6V1G1;ATP6V0E1;PAK1;MAP2K4;JAM3;ATP6V1G3;MET;ATP6V0A1;NOD1
Tuberculosis	TLR4;CAMK2B;CALML3;IL18;HLA-DPB1;ATP6V0A2;RFXANK;C3;IL6
Rheumatoid arthritis	Ctsl;TNFSF13;MMP1;ATP6AP1;CXCL1;IL1B;Il23a; Il12b;ATP6V1G2;HLA-DRB3

ATP6V0A4 has several biochemical functions, for example, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0A4 itself. We selected most functions ATP6V0A4 had, and list some proteins which have the same functions with ATP6V0A4. You can find most of the proteins on our site.

Function	Related Protein
ATPase binding	EZR;ANK2;DNAJC10;FBL;DNAJB1;GRIN2A;USP25;BBC3;FXYD4
protein binding	CYCS;UBB;APC;CASP7;FAP;EFNA4;TNKS;INPP5D;ADRA2B
proton-transporting ATPase activity, rotational mechanism	ATP6V1A;ATP6V1H;ATP6V0E1;ATP5E;ATP6V0A1B;ATP6V0A2;ATP6V1AA;ATP6V0CB;ATP6AP1B

ATP6V0A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0A4.

Research Area

Nagara, M; Voskarides, K; et al. A novel splice-site mutation in ATP6V0A4 gene in two brothers with distal renal tubular acidosis from a consanguineous Tunisian family. JOURNAL OF GENETICS 93:859-863(2014).

Zeinali, F; Mohseni, M; et al. Investigation of ATP6V1B1 and ATP6V0A4 genes causing hereditary hearing loss associated with distal renal tubular acidosis in Iranian families. JOURNAL OF LARYNGOLOGY AND OTOLOGY 128:1056-1059(2014).