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  • Official Full Name

    ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.
  • Synonyms

    ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1; ATP6B1, vacuolar proton pump 3 , VPP3; V-type proton ATPase subunit B, kidney isoform; Renal tubular acidosis with deafness; RTA1B; VATB; Vma2; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 1; kidney isoform; V type proton ATPase subunit B, kidney isoform; Vpp 3; Vpp3; Atp6b1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 1; ATPase, H+ transporting, V1 subunit B, isoform 1; Endomembrane proton pump 58 kDa subunit; H(+) transporting two sector ATPase 58kD subunit; H+ ATPase beta 1 subunit; Lysosomal 56/58kDa; MGC32642; V type proton ATPase subunit B kidney isoform; V-ATPase subunit B 1; V-type proton ATPase subunit B; Vacuolar proton pump 3; Vacuolar proton pump subunit 3; Vacuolar proton pump subunit B 1; VATB1_HUMAN; OTTHUMP00000160125; OTTHUMP00000204311; V-ATPase B1 subunit; H+-ATPase beta 1 subunit; vacuolar proton pump, subunit 3; H(+)-transporting two-sector ATPase, 58kD subunit;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V1B1-1001H Recombinant Human ATP6V1B1 protein, GST-tagged Wheat Germ GST
Human ATP6V1B1-10041H Recombinant Human ATP, His-tagged E.coli His 1-327a.a.
Human ATP6V1B1-8584HCL Recombinant Human ATP6V1B1 293 Cell Lysate HEK293 N/A
Human ATP6V1B1-1510HF Recombinant Full Length Human ATP6V1B1 Protein, GST-tagged In Vitro Cell Free System GST 513 amino acids
Mouse Atp6v1b1-490M Recombinant Mouse Atp6v1b1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATP6V1B1 Related Articles

ATP6V1B1 involved in several pathways and played different roles in them. We selected most pathways ATP6V1B1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Synaptic vesicle cycleSYT1;ATP6V0B;ATP6V0A4;ATP6V1H;CPLX2;DNM3;ATP6V1B2;STX3;ATP6V1F
Collecting duct acid secretionATP6V1E2;ATP6V0D2;ATP4A;ATP6V1C1;ATP6V0C;ATP6V1G3;ATP6V1F;ATP6V1B2;ATP6V1A
Vibrio cholerae infectionATP6V0C;PRKACG;ATP6V1B2;ATP6V0E1;ATP6V0D1;ATP6V1F;KDELR3;ATP6V1C2;ATP6V0A2
Epithelial cell signaling in Helicobacter pylori infectionCXCR1;ATP6V1E1;ATP6V1C2;RAC1;NFKB1;ATP6V1A;ATP6V0D2;MAPK11;ATP6V1D
Rheumatoid arthritisACP5;VEGFA;IL1A;CCL2;ATP6V1B2;CD86;CXCL5;CD28;ATP6AP1

ATP6V1B1 has several biochemical functions, for example, ATP binding, hydrogen ion transmembrane transporter activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1B1 itself. We selected most functions ATP6V1B1 had, and list some proteins which have the same functions with ATP6V1B1. You can find most of the proteins on our site.

Function Related Protein
hydrogen ion transmembrane transporter activityATP5IA;ATP5J;ATP5L;SLC36A2;ATP5G3B;ATPV0E2;ATP6V1B2;ATP6V0E2;SLC11A2
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesATP6V1G2;ATP6V1BA;ATP6V1AA;ATP6V1B1
protein complex bindingABI2;KRAS;PTK2B;DLG4;INS2;RARB;TELO2;RELA;VAMP2

ATP6V1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1B1.


Zeinali, F; Mohseni, M; et al. Investigation of ATP6V1B1 and ATP6V0A4 genes causing hereditary hearing loss associated with distal renal tubular acidosis in Iranian families. JOURNAL OF LARYNGOLOGY AND OTOLOGY 128:1056-1059(2014).
Nagara, M; Voskarides, K; et al. Molecular Investigation of Distal Renal Tubular Acidosis in Tunisia, Evidence for Founder Mutations. GENETIC TESTING AND MOLECULAR BIOMARKERS 18:741-748(2014).
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