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AURKB

  • Official Full Name

    aurora kinase B

  • Overview

    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
  • Synonyms

    AURKB; aurora kinase B; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2; ARK-2; STK-1; aurora 1; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora-related kinase 2; serine/threonine kinase 12; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B; protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-like midbody-associated protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • Fc
  • Avi
  • Myc
  • DDK
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AURKB-231H Recombinant Human Aurora Kinase B, His-tagged E.coli His
Human AURKB-684H Recombinant Human Aurora Kinase B, GST-His GST 2-344
Human AURKB-35H Recombinant Human AURKB/INCENP protein, Flag/His-tagged, Biotinylated Insect Cell His&Flag 1-344;803-918
Human AURKB-26601TH Recombinant Human AURKB Non
Human AURKB-1038H Recombinant Human AURKB protein, GST-tagged Wheat Germ GST
Human AURKB-27422TH Recombinant Human AURKB, His-tagged His 2-344
Human AURORA B-3778H Recombinant Human AURORA B protein, GST-tagged Insect Cell GST full-length
Human AURKB-247H Recombinant Human Aurora Kinase B, GST-tagged, Active Sf9 Insect Cell GST
Human AURKB-5292H Recombinant Human Aurora Kinase B Sf9 Insect Cell Non
Human AURKB-46H Recombinant Human AURKB protein, MYC/DDK-tagged HEK293 Myc&DDK
Human AURKB-8560HCL Recombinant Human AURKB 293 Cell Lysate HEK293 Non
Human AURKB-05H Recombinant Human AURKB (D200A) Mutant Protein, GST-tagged Insect Cell GST
Human AURKB-5410H Recombinant Human AURKB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc&DDK
Human AURKB-3924H Recombinant Human AURKB protein, His-tagged E.coli His 1-371 aa
Human AURKB-9695HFL Recombinant Full Length Human AURKB protein, Flag-tagged Mamanlian cells Flag
Human AURKB-4230HF Active Recombinant Full Length Human AURKB Protein, DDK-tagged, Biotinylated Insect (sf21) Flag 1-344(end)
Human AURKB-8990HF Active Recombinant Full Length Human AURKB Protein, GST-tagged Insect (sf21) GST 1-344(end)
Human AURKB-1104HF Recombinant Full Length Human AURKB Protein, GST-tagged In Vitro Cell Free System GST 344 amino acids
Human AURKB-1112H Recombinant Human AURKB Protein (A2-A344), Tag Free Insect Cell Non A2-A344
Human AURKB-1113H Recombinant Human AURKB Protein (A2-A344), GST tagged Insect Cell GST A2-A344
Mouse Aurkb-3781M Recombinant Mouse Aurkb, His-tagged E.Coli or Yeast His 345
Mouse AURKB-2207M Recombinant Mouse AURKB Protein Mammalian Cell His
Mouse Aurkb-1789M Recombinant Mouse Aurkb Protein, Myc/DDK-tagged HEK293T Myc&DDK
Mouse AURKB-909M Recombinant Mouse AURKB Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Mouse AURKB-909M-B Recombinant Mouse AURKB Protein Pre-coupled Magnetic Beads HEK293
Rat AURKB-904R Recombinant Rat AURKB Protein Mammalian Cell His
Rat AURKB-560R Recombinant Rat AURKB Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Rat AURKB-560R-B Recombinant Rat AURKB Protein Pre-coupled Magnetic Beads HEK293
Rat Aurkb-279R Recombinant Rat Aurkb Protein, His-tagged E.coli His Gly92-Pro339
Zebrafish AURKB-11846Z Recombinant Zebrafish AURKB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

AURKB involved in several pathways and played different roles in them. We selected most pathways AURKB participated on our site, such as APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Aurora A signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
APC/C-mediated degradation of cell cycle proteinsAURKB;ANAPC10;CDK2;PSME3;UBE2C;NEK2;PSMD9;PSMD5;PSMD10
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1PSMD14;PSMD9;AURKB;PSMD10;ANAPC10;PSME3;PSMD5;PSMA8;UBE2C
Aurora A signalingTPX2;OAZ1;AURKB;TACC3;TACC1;TDRD7;GADD45A;AURKAIP1;NDEL1
Aurora B signalingEVI5;NDC80;SGOL1;NCAPH;NPM1;NSUN2;SEPT1;CBX5;CENPA
Aurora C signalingAURKB;AURKC;INCENP
Cell CycleGADD45A;ITGB3BP;CEP164;GOLGA2;RBBP4;CCND3;ZBTB17;CSNK2A2;RB1
Cell Cycle, MitoticNDEL1;LEMD3;SPDL1;HIST3H2BB;FOXM1;GINS4;PMF1;SGOL1;INCENP
FOXM1 transcription factor networkCENPB;AURKB;CHEK2;FOXM1;CENPA;CKS1B

AURKB has several biochemical functions, for example, ATP binding, histone serine kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKB itself. We selected most functions AURKB had, and list some proteins which have the same functions with AURKB. You can find most of the proteins on our site.

Function Related Protein
ATP bindingHSPA4A;DDX5;MAP3K14;CDK18;LONP1;ABL2;RIOK1;GLULA;SLFNL1
histone serine kinase activityAURKB;PRKAA2;ATM;AURKA;PRKAA1;AURKC
metal ion bindingPGCP;HBBE1.1;QTRT1;AKAP13;ZNF143A;HDAC8;POLR2A;MTMR3;KLF6
protein bindingNKD1;BCKDHA;SH3PXD2B;BCL2;SUN2;BCL2L10;DRG2;APOBEC2A;NFE2L1
protein serine/threonine kinase activityMAPK8;STK32A;ADCK5;RIOK3;PRKDC;MAP4K4;WNK2;SNRK;ACVR2AA
protein serine/threonine/tyrosine kinase activityAURKB;ACVR2B;SGK1;RPS6KB1;MAP2K1;AKT1;DYRK4;CLK4;RPS6KA1

AURKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKB here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKB.

BIRC5; INCENP; SEPT1

  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
12/28/2021

    AURKB's exceptional repeatability allows for its reliable use in a range of applications, making it a top choice for researchers.

    08/31/2021

      Very pure and can be used with confidence.

      02/03/2019

        The quality is very high and very reliable.

        Q&As (6)

        Ask a question
        What are the interactions between AURKB protein and cell cycle regulatory proteins? 12/03/2022

        AURKB protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, INCENP, Survivin, etc., to regulate the progression of cell mitosis.

        What are the intracellular substrates of AURKB protein? 09/09/2022

        The substrates of AURKB include chromosome-associated proteins, cytoskeletal proteins and other cell cycle regulatory proteins. Phosphorylation modification of these substrates regulates chromosome segregation and cell division during mitosis.

        What is the cellular localization of AURKB protein? 06/30/2021

        AURKB protein is mainly located in the nucleus and cytoplasm and participates in the regulation of cell mitosis.

        What is the expression pattern of AURKB gene? 08/11/2020

        The expression of the AURKB gene is regulated by cell cycle regulators and other transcription factors and is mainly expressed in the mitotic phase of cells.

        How does AURKB protein activity work? 03/14/2020

        The activity of AURKB protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

        At what stage of cell mitosis does AURKB protein reach its peak expression? 04/08/2019

        The protein reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.

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