AURKB
-
Official Full Name
aurora kinase B
-
Overview
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013] -
Synonyms
AURKB; aurora kinase B; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2; ARK-2; STK-1; aurora 1; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora-related kinase 2; serine/threonine kinase 12; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B; protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-like midbody-associated protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
AURKB involved in several pathways and played different roles in them. We selected most pathways AURKB participated on our site, such as APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Aurora A signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
APC/C-mediated degradation of cell cycle proteins | AURKB;ANAPC10;CDK2;PSME3;UBE2C;NEK2;PSMD9;PSMD5;PSMD10 |
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | PSMD14;PSMD9;AURKB;PSMD10;ANAPC10;PSME3;PSMD5;PSMA8;UBE2C |
Aurora A signaling | TPX2;OAZ1;AURKB;TACC3;TACC1;TDRD7;GADD45A;AURKAIP1;NDEL1 |
Aurora B signaling | EVI5;NDC80;SGOL1;NCAPH;NPM1;NSUN2;SEPT1;CBX5;CENPA |
Aurora C signaling | AURKB;AURKC;INCENP |
Cell Cycle | GADD45A;ITGB3BP;CEP164;GOLGA2;RBBP4;CCND3;ZBTB17;CSNK2A2;RB1 |
Cell Cycle, Mitotic | NDEL1;LEMD3;SPDL1;HIST3H2BB;FOXM1;GINS4;PMF1;SGOL1;INCENP |
FOXM1 transcription factor network | CENPB;AURKB;CHEK2;FOXM1;CENPA;CKS1B |
AURKB has several biochemical functions, for example, ATP binding, histone serine kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKB itself. We selected most functions AURKB had, and list some proteins which have the same functions with AURKB. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | HSPA4A;DDX5;MAP3K14;CDK18;LONP1;ABL2;RIOK1;GLULA;SLFNL1 |
histone serine kinase activity | AURKB;PRKAA2;ATM;AURKA;PRKAA1;AURKC |
metal ion binding | PGCP;HBBE1.1;QTRT1;AKAP13;ZNF143A;HDAC8;POLR2A;MTMR3;KLF6 |
protein binding | NKD1;BCKDHA;SH3PXD2B;BCL2;SUN2;BCL2L10;DRG2;APOBEC2A;NFE2L1 |
protein serine/threonine kinase activity | MAPK8;STK32A;ADCK5;RIOK3;PRKDC;MAP4K4;WNK2;SNRK;ACVR2AA |
protein serine/threonine/tyrosine kinase activity | AURKB;ACVR2B;SGK1;RPS6KB1;MAP2K1;AKT1;DYRK4;CLK4;RPS6KA1 |
AURKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKB here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKB.
BIRC5; INCENP; SEPT1
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewAURKB's exceptional repeatability allows for its reliable use in a range of applications, making it a top choice for researchers.
Very pure and can be used with confidence.
The quality is very high and very reliable.
Q&As (6)
Ask a questionAURKB protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, INCENP, Survivin, etc., to regulate the progression of cell mitosis.
The substrates of AURKB include chromosome-associated proteins, cytoskeletal proteins and other cell cycle regulatory proteins. Phosphorylation modification of these substrates regulates chromosome segregation and cell division during mitosis.
AURKB protein is mainly located in the nucleus and cytoplasm and participates in the regulation of cell mitosis.
The expression of the AURKB gene is regulated by cell cycle regulators and other transcription factors and is mainly expressed in the mitotic phase of cells.
The activity of AURKB protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.
The protein reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.
Ask a Question for All AURKB Products
Required fields are marked with *
My Review for All AURKB Products
Required fields are marked with *