AZGP1
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Official Full Name
alpha-2-glycoprotein 1, zinc-binding
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Synonyms
AZGP1; alpha-2-glycoprotein 1, zinc-binding; alpha 2 glycoprotein 1, zinc; zinc-alpha-2-glycoprotein; ZA2G; ZAG; Alpha 2 glycoprotein 1 zinc; ZA2G_HUMAN; Zinc alpha 2 glycoprotein precursor; Zn alpha 2 glycoprotein; Zn alpha 2 GP; Zn-alpha-2-glycoprotein; Zn-alpha-2-GP; ZNGP1; Zn-alpha2-glycoprotein; Alpha-2-glycoprotein, zinc;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
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- Rhesus Macaque
- E.coli
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- In Vitro Cell Free System
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- Mammalian cells
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- Non
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- Involved Pathway
- Protein Function
- Interacting Protein
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What is AZGP1 protein?
AZGP1 ( alpha-2-glycoprotein 1, zinc-binding) gene is a protein coding gene which situated on the long arm of chromosome 7 at locus 7q22. This gene encodes a protein called Zinc-alpha-2-glycoprotein (ZAG), also known as AZGP1. This protein is found in body fluids such as serum, sweat, and seminal and breast cyst fluids. It is identical in amino acid sequence to tumor-derived lipid mobilizing factor (LMF), a protein associated with the dramatic loss of adipose body stores in cancer cachexia, and has been shown to stimulate lipolysis by adipocytes in vivo and in vitro. ZAG exhibits a class I major histocompatibility complex (MHC) fold but is a soluble protein rather than being anchored to plasma membranes and does not associate with alpha-2-microglobulin in humans. This protein is consisted of 298 amino acids and is approximately 34.2 kDa.
What is the Function of AZGP1 protein?
AZGP1 is a multidisciplinary protein, which is secreted in various body fluids. The AZGP1 plays roles in lipolysis, regulation of metabolism, cell proliferation and differentiation, regulation of melanin synthesis, cell adhesion, and immunoregulation.
It can bind to DNA and interact with transcription factors, thereby influencing the transcription of these genes. One of the well-known functions of AZGP1 is its involvement in lipid metabolism and adipose tissue regulation. It has been shown to promote lipolysis (the breakdown of fats) in adipocytes and enhance the release of fatty acids into the bloodstream for energy production.
AZGP1 Related Signaling Pathway
The P-AKT/GLUT4 signaling pathway is an important downstream pathway for insulin action, and AZGP1 can alter the sensitivity of adipocytes to glucose and further affect blood glucose control by affecting this signaling pathway. It was also found that Renvastinib can activate AZGP1 by increasing the acetylation level of H3K27Ac in AZGP1 promoter region, and regulate TGF-β1/Smad3 signaling pathway in an AZGP1-dependent manner, thereby inhibiting liver cancer cell migration and invasion (ICC-EMT).
Fig1. Schematic diagram of lenvatinib inhibition of EMT in ICC cells. Lenvatinib enhanced AZGP1 activity through H3K27Ac modification and inhibited the downstream TGF-β1/Smad3 signaling pathway. (Liming Deng, 2023)
AZGP1 Related Diseases
AZGP1 is expressed at reduced levels in some tumors and is therefore considered a tumor suppressor protein. It has been found that the expression level of AZGP1 is closely related to tumor growth, metastasis and prognosis in a variety of cancers, such as prostate cancer and lung cancer. AZGP1 may also be involved in the occurrence and development of metabolic diseases such as insulin resistance and obesity.
Bioapplications of AZGP1
AZGP1 has a promising application in metabolic regulation, cancer diagnosis and treatment, and immune regulation. For example, AZGP1 may be a potential key target for Lenvatinib in the treatment of hepatocellular carcinoma (ICC).
High Purity
Fig1. SDS-PAGE (AZGP1-1052H) (PROTOCOL for western blot)
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Fig2. SDS-PAGE (AZGP1-283H) (PROTOCOL for western blot)
Case Study 1: Peng Jin, 2023
Fig1. The expression of AZGP1 protein by IHC in control.
Case Study 2: Miroslav Balaz, 2014
Fig2. The representative western blot shows adipose tissue ZAG protein content in subcutaneous (S) and visceral (V) adipose tissue of three lean and three obese individuals.
AZGP1 involved in several pathways and played different roles in them. We selected most pathways AZGP1 participated on our site, such as Miscellaneous transport and binding events, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with AZGP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Miscellaneous transport and binding events | MAGT1;EPB49;NIPA1;AZGP1;ANKH;NIPAL3;ADD3B;MMGT1;ADD3 |
| Transmembrane transport of small molecules | SLC35B4;CLCNK;SLC22A7B.1;SLC2A13;SLC7A6;SLC6A19A;SLC6A6;SLC43A1A;MCOLN2 |
AZGP1 has several biochemical functions, for example, glycoprotein binding, peptide antigen binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AZGP1 itself. We selected most functions AZGP1 had, and list some proteins which have the same functions with AZGP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycoprotein binding | LRRK2;CANX;RGMA;CNTN2;IDE;Shh;FLNA;SERPINA1A;FBXO17 |
| peptide antigen binding | MHC1UDA;HLA-DRB3;MHC1ZBA;H2-AA;HLA-E;CLEC4M;MHC1UBA;MHC1ZFA;MHC1ZKA |
| protein binding | ZBTB9;PRF1;INCENP;ARL13B;SMIM3;C1orf189;FAM114A1;TNFRSF1A;THEM5 |
| protein transmembrane transporter activity | AZGP1;BLOC1S3;TOMM22;TOMM40;TOMM70A;GPIHBP1;TOMM7 |
| ribonuclease activity | RNASEL4;RNASE4;EAR1;RNASE2;ANG;RNASEH1;RNASEH2A;RNASET2;ERN2 |
AZGP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AZGP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AZGP1.
USP53; Ikbip; f_hcvh; ABCC1; NUF2; q9wmx2-pro_0000037550; RASSF10; RASSF9; GABARAPL2; STK4; CDK19
Research Area
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewWhat further sets the AZGP1 Protein apart is the outstanding technical support provided by the manufacturer.
Considering the aforementioned qualities, I wholeheartedly recommend the AZGP1 Protein to fellow researchers in search of a top-tier protein solution that not only meets their experimental needs but also benefits from exceptional technical support.
By incorporating the AZGP1 Protein into their studies, scientists have the opportunity to conduct their research with utmost confidence, paving the way for groundbreaking discoveries and novel insights in their respective fields.
Q&As (5)
Ask a questionYes, AZGP1 is implicated in metabolic disorders, and its study may offer insights into the development of therapies for conditions like obesity and diabetes.
AZGP1 is primarily found in various tissues, including the liver, adipose tissue, and prostate.
Some studies suggest that AZGP1 may have immunomodulatory properties, and its role in inflammation is an area of active investigation.
AZGP1 is involved in lipid metabolism and has been linked to the regulation of adipose tissue and energy homeostasis.
AZGP1 is involved in lipid metabolism and has been linked to the regulation of adipose tissue and energy homeostasis.
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