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AZU1

Official Full Name

azurocidin 1
Overview

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Jul 2008]
Synonyms

AZU1; azurocidin 1; AZU; HBP; NAZC; AZAMP; CAP37; HUMAZUR; azurocidin; neutrophil azurocidin; heparin-binding protein; cationic antimicrobial protein 37; cationic antimicrobial protein CAP37;

Type

Recombinant Proteins
Cell & Tissue Lysates
Native Proteins

Species

Human

Source

E.coli
HEK293
HEK293 cells
Human Cell
Human Neutrophil
In Vitro Cell Free System
Insect Cells
Mammalian cells
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	AZU1-588H	Recombinant Human AZU1 protein, His-tagged	HEK293	His	Ile27-Pro250	$498 / 50 µg
Human	AZU1-6989H	Recombinant Human AZU1 protein, His-tagged	E.coli	His	Pro23~Gly247 (Accession # P20160)	Inquiry
Human	AZU1-1055H	Recombinant Human AZU1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	AZU1-3083HCL	Recombinant Human AZU1 cell lysate	Human Cell	N/A		Inquiry
Human	AZU1-0045H	Recombinant Human AZU1 Protein	HEK293 cells			Inquiry
Human	AZU1-1303H	Recombinant Human AZU1 protein, His-tagged	HEK293	His	27-248aa	Inquiry
Human	AZU1-094H	Recombinant Human AZU1 Protein, His-tagged	HEK293	His	251	Inquiry
Human	AZU1-26565TH	Native Human AZU1	Human Neutrophil	N/A	222 amino acids	Inquiry
Human	AZU1-0724H	Recombinant Human AZU1 Protein (Pro23-Gly247), His tagged	E.coli	His	Pro23-Gly247	Inquiry
Human	AZU1-1594H	Recombinant Human AZU1 Protein (Ile27-Pro250), C-His tagged	Mammalian cells	C-His	Ile27-Pro250	Inquiry
Human	AZU1-40H	Native Human Azurocidin	Human Neutrophil	N/A		Inquiry
Human	AZU1-1547HF	Recombinant Full Length Human AZU1 Protein, GST-tagged	In Vitro Cell Free System	GST	251 amino acids	Inquiry
Human	AZU1-5024H	Recombinant Human AZU1 Protein (Met1-R1036), C-His tagged	Insect Cells	C-His	Met1-R1036	Inquiry

Involved Pathway
Protein Function
Interacting Protein

AZU1 involved in several pathways and played different roles in them. We selected most pathways AZU1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AZU1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

AZU1 has several biochemical functions, for example, heparan sulfate proteoglycan binding, heparin binding, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AZU1 itself. We selected most functions AZU1 had, and list some proteins which have the same functions with AZU1. You can find most of the proteins on our site.

Function	Related Protein
heparan sulfate proteoglycan binding	Gpc2;ITGAM;UBE4A;Itgam&Itgb2;GPC1;HRG;GPC1B;AGRN;CFH
heparin binding	FGFR4;LIPI;FGF4;ANG;NDNF;LTF;APOA5;SLIT1B;FGF9
peptidase activity	SOLH;ESPL1;MEP1A.1;NAALADL1;PAPPAB;CTRC;NPEPPS;Adamts19;Gzmd
protein binding	PDE4A;RAP1A;THAP6;FBXO32;WFDC9;NCOA5;KLF11;AP1B1;PRLR
serine-type endopeptidase activity	KLK1B9;C1S;C1rb;TPP1;PREP;TMPRSS11B;HTRA3A;PRSS59.2;FURINB
toxic substance binding	H2-AB1;CHRNA7;A4GALT;DSG1;NEFH;ASS1;PHAX;GUCY2C;Alb

AZU1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AZU1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AZU1.

CLEC4G; dsdna_dcmdg:dcmdg; A2M