BAAT
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Official Full Name
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) -
Overview
The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
BAAT;bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase);bile acid Coenzyme A: amino acid N acyltransferase (glycine N choloyltransferase);bile acid-CoA:amino acid N-acyltransferase;BAT;FLJ20300;BACAT;Bile acid CoA:amino acid N acyltransferase;Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase;Bile acid Coenzyme A: amino acid N acyltransferase;Glycine N choloyltransferase;Long chain fatty acyl CoA hydrolase;MGC104432;OTTHUMP00000021802;long-chain fatty-acyl-CoA hydrolase;bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
BAAT involved in several pathways and played different roles in them. We selected most pathways BAAT participated on our site, such as Primary bile acid biosynthesis,Taurine and hypotaurine metabolism,Biosynthesis of unsaturated fatty acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biosynthesis of unsaturated fatty acids | FADS2,ACOT7,ACAA1A,PTPLA,ACOX3,HADHAA,ELOVL2,Scd1,ACOT5,ACOT1 |
| Bile secretion | Adcy4,AQP9,CFTR,AQP1,SLCO1A5,ADCY9,SLC27A5,ATP1A3,NR0B2,CA2 |
| Primary bile acid biosynthesis | HSD3B7,ACOX2,AKR1C4,SCP2A,CYP8B1,SLC27A5,CYP46A1,CYP46A1.3,CH25HL2,AKR1D1 |
| Metabolic pathways | NADK2,MTHFD2,MT-ATP6,ST3GAL3B,CYP2B6,QARS,RRM2,LIAS,ACADSB,SPTLC2 |
| Peroxisome | PEX11A,HACL1,ACSL5,ACSL3A,DAO.1,FAR1,CRATB,HAO2,PEX5L,MPV17 |
| Taurine and hypotaurine metabolism | GGT5,GAD1,GGT1,ADO,CSAD,ADOB,GAD1B,GGT7,GGT1A,GAD2 |
Protein Function
BAAT has several biochemical functions, for example, N-acyltransferase activity,carboxylic ester hydrolase activity,glycine N-choloyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BAAT itself. We selected most functions BAAT had, and list some proteins which have the same functions with BAAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acyltransferase activity | Acnat1,LPCAT3,DGAT2L6,MBOAT7,MBOAT1,CML2,NAT14,HHAT,HRASLS5,CML5 |
| palmitoyl-CoA hydrolase activity | ACOT1,ACOT5,THEM4,THEM5,PPT1,ACOT2,GNPAT,ACOT8,ACOT7 |
| carboxylic ester hydrolase activity | Ces2e,ABHD2,CES1,NOTUM1A,AADACL4,LIPCA,ACOT2,LYPLAL1,FAM135A,ACOT8 |
| medium-chain acyl-CoA hydrolase activity | ACOT8 |
| receptor binding | ADAM10,CADM2A,FGF20A,SCYL2,SMARCD1,FGF10A,CADM1A,LPL,GBA,AKAP9 |
| protein binding | ZFP335,VDAC2,DAB1,SEMA6A,DRAP1,ATG101,LRPPRC,KRTAP8-1,TBL1XR1,UBE2I |
Interacting Protein
BAAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAAT here. Most of them are supplied by our site. Hope this information will be useful for your research of BAAT.
GOLGA8F;GOLGA8DP;AURKA;BUB1;BCL10;ERBB2;RB1;ODC1;SRC;MCC;APC;CTNNA1;MLH1;PTPRJ;SMAD4;PDGFRL
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