BBS1

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BBS1

Official Full Name Bardet-Biedl syndrome 1 (human)
Background Bardet-Biedl syndrome 1 protein is a protein that in humans is encoded by the BBS1 gene.
Synonyms BBS1; Bardet-Biedl syndrome 1 (human); Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 1 protein; BBS1_HUMAN; BBS2-like protein 2; Bardet-Biedl syndrome 1 homolog; AI451249; D19Ertd609e
    • Species :
    • Human
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BBS1-104H Recombinant Human BBS1 Protein, GST-tagged Wheat Germ GST
    Human BBS1-105H Recombinant Human BBS1 Protein, GST-tagged Wheat Germ GST
    Human BBS1-8504HCL Recombinant Human BBS1 293 Cell Lysate HEK293 N/A
    Zebrafish BBS1-5671Z Recombinant Zebrafish BBS1 Mammalian Cell His

    BBS1 involved in several pathways and played different roles in them. We selected most pathways BBS1 participated on our site, such as Assembly of the primary cilium, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of the primary cilium TUBB4A; MAPRE1; CEP72; CEP290; CENPJ; FBF1; CCT8; IQCB1; KIFAP3; CCT4
    BBSome-mediated cargo-targeting to cilium BBS9; MKKS; BBS5; BBS1; TCP1; BBS2; CCT2; BBS10; BBS7; SSTR3
    Cargo trafficking to the periciliary membrane MKKS; RHOL; ARL13B; BBS4; PKD2; CCT5; EXOC3; CNGA5; BBS1; CNGA2
    Organelle biogenesis and maintenance IFT27; EXOC6; MARK4; MKKS; TFB1M; HSPB11; CNGA2; MRPL38; BBS13; MRPS31

    BBS1 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, patched binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS1 itself. We selected most functions BBS1 had, and list some proteins which have the same functions with BBS1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II repressing transcription factor binding TTC8; PPARA; TBP; RBPJ; PROL1; BBS10; HDAC1; RBBP8; MTA1; SP1
    patched binding PTCH1; CCNB1; IHH; DHH; CAV1; SETD6; Shh; BBS1; SMO
    protein binding DOK1; HIST1H4K; MRC1; MAPK11; GALR1; PDZD3; FAM59A; TAX1BP1; MBIP; RIPPLY3
    smoothened binding PTCH1; BBS1; PTCH2

    BBS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS1.

    BBS9; BBS7; BBS5; BBS4

    Rabinovich-Nikitin, I; Solomon, B; et al. Inhibition of Amyloid Precursor Protein Processing Leads to Downregulation of Apoptotic Genes in Alzheimer's Disease Animal Models. NEURODEGENERATIVE DISEASES 13:107-109(2014).
    Seo, S; Mullins, RF; et al. Subretinal Gene Therapy of Mice With Bardet-Biedl Syndrome Type 1. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:6118-6132(2013).

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