|Official Full Name||Bardet-Biedl syndrome 4|
|Background||This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse. The similar phenotypes exhibited by mutations in BBS gene family members are likely due to the proteins shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene has sequence similarity to O-linked N-acetylglucosamine (O-GlcNAc) transferases in plants and archaebacteria and in human forms a multi-protein "BBSome" complex with six other BBS proteins. Alternative splice variants have been described but their predicted protein products have not been experimentally verified.|
|Synonyms||BBS4; Bardet-Biedl syndrome 4; Bardet-Biedl syndrome 4 protein; Bardet Biedl syndrome 4 protein; BBS4_HUMAN|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
BBS4 involved in several pathways and played different roles in them. We selected most pathways BBS4 participated on our site, such as Assembly of the primary cilium, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Assembly of the primary cilium||FGFR1OP; NPHP1; CEP97; CCT4; MKKS; IFT20; NEK2; KIF3A; ODF2B; B9D2|
|BBSome-mediated cargo-targeting to cilium||PROL1; BBS1; BBS2; SETD6; BBS7; BBS10; LZTFL1; BBS9; CCT5; CCT8|
|Cargo trafficking to the periciliary membrane||MKKS; EXOC6; BBS10; CNGA2; UNC119B; BBS1; ARF4A; BBS9; PROL1; CCT2|
|Organelle biogenesis and maintenance||IFT43; MRPS27; WDR34; MRPS31; TTBK2; IFT20; NPHP1; PKD1; MRPS33; FBF1|
BBS4 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, alpha-tubulin binding, beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS4 itself. We selected most functions BBS4 had, and list some proteins which have the same functions with BBS4. You can find most of the proteins on our site.
|RNA polymerase II repressing transcription factor binding||PROL1; TTC8; RBPJ; BBS2; SIN3A; MKKS; STAT3; TCF7L2; SP1; MTA1|
|alpha-tubulin binding||NDEL1; NCALD; PROL1; CAV3; PPARGC1A; HDAC6; PACRG; SPAST; DDL-2; FAM110C|
|beta-tubulin binding||EMD; UXT; PROL1; SPAST; RGS2; MAP1S; AKAP1; TBCD; SLC6A2; LRPPRC|
|dynactin binding||CCDC64; PROL1; BICD1; SNX5; SNX6; HTT; BBS4|
|microtubule motor activity||DNAI2; DNAH14; BBS4; KIF21A; KLC2; KIFC2; KIF14; DNAHC8; KIF12; KLC1B|
|protein binding||PARVA; HTR6; CDC26; CWC15; PKN3; BCR; IFITM3; PIK3R4; CD200R1; TA|
BBS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS4.