|Official Full Name||Bardet-Biedl syndrome 7|
|Background||This gene encodes one of seven proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy; however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene.|
|Synonyms||BBS7; Bardet-Biedl syndrome 7; Bardet-Biedl syndrome 7 protein; BBS2L1; FLJ10715; BBS2-like 1; BBS2-like protein 1; OTTHUMP00000164091; OTTHUMP00000219992|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
BBS7 involved in several pathways and played different roles in them. We selected most pathways BBS7 participated on our site, such as Assembly of the primary cilium, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Assembly of the primary cilium||TCTN1; RHOL; ATAT1; PKD2; DYNLL2A; KIF3B; NEK2; BBS13; TCTEX1D2; CCT2|
|BBSome-mediated cargo-targeting to cilium||BBS9; BBS2; TCP1; CCT4; CCT2; BBS7; PROL1; BBS12; CCT5; SETD6|
|Cargo trafficking to the periciliary membrane||EXOC8; CNGA2; MKKS; CCT3; PROL1; BBS4; BBS12; UNC119.1; CCT2; EXOC5|
|Organelle biogenesis and maintenance||DYNLRB2; TCTEX1D2; TTC30B; MRPL55; MARK4; IFT27; TMEM216; HSPB11; IFT88; NPHP1|
BBS7 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS7 itself. We selected most functions BBS7 had, and list some proteins which have the same functions with BBS7. You can find most of the proteins on our site.
|RNA polymerase II repressing transcription factor binding||TBP; SP1; MKKS; TCERG1; GATA6; RBPJ; SIN3A; HDAC1; BBS5; CHD4|
|protein binding||PHOSPHO2; LRPPRC; ZNF232; BICD1; PTMA; SERTAD1; TUBA1A; CDKL3; AP5S1; GFOD1|
BBS7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS7 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS7.
BBS2; BBS1; MKKS