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Official Full Name B-cell CLL/lymphoma 10
Background This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Synonyms BCL10; B-cell CLL/lymphoma 10; CLAP; mE10; CIPER; c-E10; CARMEN
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BCL10-1016H Recombinant Human B-cell CLL/lymphoma 10 Sf9 Insect Cell N/A
    Human BCL10-141H Recombinant Human BCL10 Protein, GST-tagged Wheat Germ GST
    Human BCL10-16H Recombinant Human BCL10 Protein, His-tagged E. coli His
    Human BCL10-8490HCL Recombinant Human BCL10 293 Cell Lysate HEK293 N/A
    Human BCL10-8496H Recombinant Human BCL10, His-tagged Sf21 Insect Cell His
    Mouse Bcl10-555M Recombinant Mouse Bcl10 Protein, His-tagged E.coli His
    Rat BCL10-956R Recombinant Rat BCL10 Protein Mammalian Cell His
    Rhesus Macaque BCL10-521R Recombinant Rhesus monkey BCL10 Protein, His-tagged Mammalian Cell His
    Chicken BCL10-4495C Recombinant Chicken BCL10 Mammalian Cell His

    BCL10 involved in several pathways and played different roles in them. We selected most pathways BCL10 participated on our site, such as NF-kappa B signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway PIAS4; LTB; TICAM2; PRKCQ; IKBKB; Bcl2a1b; CD40; IRAK4; ATM; SYK
    T cell receptor signaling pathway CD3D; PPP3R1; MAPK3; SHB; PDPK1; CD8A; CD28; IKBKB; FYN; AKT2
    B cell receptor signaling pathway CDK7; CRKL; PPP3CA; PDK2; LCP2A; PIK3R2; DOK3; BTK; HDAC5; RAF1
    Tuberculosis HLA-DRB1; PPP3R1; STAT1; FCGR1; PPP3R2; MRC1; RAF1; TLR9; RAB7; RFX5

    BCL10 has several biochemical functions, for example, NF-kappaB binding, enzyme binding, contributes_to kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL10 itself. We selected most functions BCL10 had, and list some proteins which have the same functions with BCL10. You can find most of the proteins on our site.

    Function Related Protein
    NF-kappaB binding BCL10; HDAC2; FAF1; NFKBID; PSMA6; NPM1; CPNE1; HIF1AN; NFKBIA; RELA
    enzyme binding SCNM1; EHHADH; CDC20; TRP53; TSPAN17; CBX1; AXIN1; SELS; Alb; UGT1A7
    contributes_to kinase activator activity BCL10; MALT1
    kinase binding MOBKL1A; SNAI1; SGOL1; TOLLIP; ATF5; PFKL; LDHA; FAS; PRKCD; DLG4
    protease binding XBP1; SERPINB9; DERL1; STIM1; A2M; SELL; HSPD1; ITGB1; TIMP3; TNF
    protein C-terminus binding CTBP1; BLOC1S2; KCNIP3; ITPR1; NEFL; PRKAA1; PQBP1; PHB2; MKI67; ZBTB16
    protein binding NIF3L1; FN1; BACH1; DBF4B; C19orf73; ANKRD49; MORN4; RFX3; DAZL; PPHLN1
    protein kinase B binding BAD; TRAF6; CDC37; PDE3B; PINK1; APPL1; ANKRD2; BCL10; RARA; CCDC88A
    protein kinase binding TOM1L1; CACNB4; TRPV4; ITGB1BP1; CCND3; CCND1; HIF1A; STAP1; RAB8A; CEP68
    protein self-association BCL10; DVL2; TP53; CCDC88C; ZSWIM2; SVIP; ACHE; CBR2; SHANK3; AGTR1B
    transcription coactivator activity SUPT7L; APEX1; RXRA; WWC1; PML; ABT1; YAF2; TAF7L; SNW1; MYOCD
    transcription factor binding POU1F1; PIAS1; GATA6; RBPJ; FLNA; DNMT1; HMGA1; APBB1; E2F5; POU5F1
    ubiquitin binding SMAD3; UBE2N; UBXN2B; RNF31; NBR1; UBR5; NPLOC4; SQSTM1; OTUB1; PARK2
    ubiquitin protein ligase binding WFS1; MC4R; ACTG1; PRDX6; CLU; MAGEC2; FZD6; PRKACB; FAF1; TRIM28

    BCL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL10.

    MALT1; AKT1; CARD11

    Punwani, D; Wang, HP; et al. Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation. JOURNAL OF CLINICAL IMMUNOLOGY 35:135-146(2015).
    Zhao, XQ; Zhu, LL; et al. C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6 '-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-kappa B Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:30052-30062(2014).

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