BCL2L1

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BCL2L1

Official Full Name BCL2-like 1
Background The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
Synonyms BCL2L1; BCL2-like 1; BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S; bcl-2-like protein 1; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His-SUMO
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BCL2L1-139H Recombinant Human BCL2L1 protein, GST-tagged E. coli GST
    Human BCL2L1-2581H Recombinant Human BCL2L1 protein, His-SUMO-tagged E.coli His-SUMO
    Human BCL2L1-10191H Recombinant Human BCL2L1, His-tagged E.coli His
    Human BCL2L1-1349H Recombinant Human BCL2L1, GST-tagged E.coli GST
    Human BCL2L1-147H Recombinant Human BCL2L1 Protein, GST-tagged Wheat Germ GST
    Human BCL2L1-168H Recombinant Human BCL2L1 Protein E.coli N/A
    Human BCL2L1-1851H Recombinant Human BCL2-like 1, His-tagged E.coli His
    Human BCL2L1-323H Recombinant Human BCL2L1 protein, GST-tagged E.coli GST
    Human BCL2L1-3321H Recombinant Human BCL2L1 Protein E. coli N/A
    Human BCL2L1-348H Recombinant Human BCL2L1 protein E.coli N/A
    Human BCL2L1-457H Recombinant Human BCL2L1 Mammalian Cell His
    Human BCL2L1-470H Recombinant Human BCL2-Like 1 E.coli N/A
    Human BCL2L1-511H Recombinant Human BCL2L1 protein, His-tagged E.coli His
    Human BCL2L1-6872H Recombinant Human BCL2L1, His tagged E.coli His
    Human BCL2L1-8488HCL Recombinant Human BCL2L1 293 Cell Lysate HEK293 N/A
    Human BCL2L1-8489HCL Recombinant Human BCL2L1 293 Cell Lysate HEK293 N/A
    Mouse Bcl2l1-544M Recombinant Mouse Bcl2l1 protein E.coli N/A
    Mouse Bcl2l1-6871M Recombinant Mouse Bcl2l1, His tagged E.coli His
    Mouse Bcl2l1-698M Recombinant Mouse Bcl2l1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Bcl2l1-74M Recombinant Mouse Bcl2l1 protein, His-tagged Insect Cell His
    Rat Bcl2l1-1242R Recombinant Rat Bcl2l1 protein, His-tagged E.coli His
    Rat BCL2L1-958R Recombinant Rat BCL2L1 Protein Mammalian Cell His
    Rhesus Macaque BCL2L1-523R Recombinant Rhesus monkey BCL2L1 Protein, His-tagged Mammalian Cell His
    Chicken BCL2L1-2207C Recombinant Chicken BCL2L1 Mammalian Cell His
    Zebrafish BCL2L1-9318Z Recombinant Zebrafish BCL2L1 Mammalian Cell His

    BCL2L1 involved in several pathways and played different roles in them. We selected most pathways BCL2L1 participated on our site, such as Ras signaling pathway, NF-kappa B signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway GNGT1; PLA2G1B; PRKACG; INS1; MET; RAB5C; MAP2K1; SHC4; RASA3; PLA2G6
    NF-kappa B signaling pathway ZAP70; NFKBIA; GM10591; CCL13; IKBKB; CCL19; TNF; TNFRSF13C; RELA; UBE2I
    PIK-Akt signaling pathway TP53; THBS1; TCL1; YWHAZ; COL6A5; GNG10; ITGB8; IFNB1; COL24A1; GNG12
    Apoptosis CSF2RB; IRAK3; CASP10; PIK3CA; NFKB1; PIK3R3B; BIRC5A; BAD; IL3; BNIP3LB
    Jak-STAT signaling pathway Ifnlr1; IL29; IL3; CRFB16; Ifnl2; SOCS3B; IL10RA; HRAS; IFNK; Ifna11
    Amyotrophic lateral sclerosis (ALS) TNF; NOS1; BID; PPP3R2; MAP2K6; MAP3K5; GPX1; GRIN2D; DERL1; CCS
    Toxoplasmosis Casp3; PIK3CG; BAD; MAPK9; HLA-DRB5; BCL2; HSPA8; PIK3CA; NOS2; IL12B
    HTLV-I infection MRAS; PDGFA; SFPI1; PTTG2; HLA-B; EGR1; WNT7B; HLA-DRB4; CD40; WNT7A
    Pathways in cancer FIGF; CUL2; PTCH2; TGFBR2; MAPK8; TCF7; Casp3; PRKACB; RAC2; GNA11
    Transcriptional misregulation in cancer NFKBIZ; HDAC1; HHEX; PTCRA; RXRB; EYA1; LDB1; FLT1; NFKB1; RUNX1
    Pancreatic cancer AKT2; ERBB2; PIK3CB; TRP53; MAPK1; CDC42; RB1; RAC2; MAPK9; STAT3
    Chronic myeloid leukemia TGFB3; RB1; RELA; PIK3CG; SHC3; KRAS; MAP2K1; PIK3R1; IKBKG; NFKB1
    Small cell lung cancer AKT1; ITGAV; ITGA2B; TRAF6; PIK3CB; BCL2L1; PIK3R5; ITGA2; NOS2; PIK3CG

    BCL2L1 has several biochemical functions, for example, BH3 domain binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2L1 itself. We selected most functions BCL2L1 had, and list some proteins which have the same functions with BCL2L1. You can find most of the proteins on our site.

    Function Related Protein
    BH3 domain binding BCL2; MCL1; BAX; BCL2L1
    identical protein binding SYT9; FRS3; CLDN8; SNX33; PKD2L1; PRNP; SCUBE1; SAFB2; SCHIP1; L3MBTL1
    protein binding ZMYND19; TAGLN2; DSC2; MYL7; LRPPRC; CLDN16; RASL10B; ANKRD10; FABP1; C2orf57
    protein heterodimerization activity HIST1H2BL; SOX6; JDP2; TOP2B; APOA2; NFYB; TENM3; GTF2A2; MCL1B; ZBTB1
    protein homodimerization activity LRRFIP1; ABAT; DSCAML1; EIF2AK3; GAMT; BCL2A1A; TBX18; ABCB10; HHEX; G6PDX
    protein kinase binding DNAJC3; PLK1; MAPK8IP2; TNIP2; HDAC7A; STXBP1; SPRY2; CEP68; CAMK2N2; CDK5R1

    BCL2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2L1.

    BAD; BAX; NLRP1

    Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
    Lee, BS; Cha, HY; et al. AY4, an agonistic anti-death receptor 4 MAB, induces apoptotic cell death in anaplastic thyroid cancer cells via downregulation of Bcl-xL with reactive oxygen species generation. ENDOCRINE-RELATED CANCER 20:283-291(2013).

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