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BCLAF1

Official Full Name

BCL2-associated transcription factor 1
Overview

This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

BCLAF1; BCL2-associated transcription factor 1; bcl-2-associated transcription factor 1; BTF; KIAA0164; bK211L9.1;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BCLAF1-8475HCL	Recombinant Human BCLAF1 293 Cell Lysate	HEK293	Non		Inquiry
Human	BCLAF1-301423H	Recombinant Human BCLAF1 protein, GST-tagged	E.coli	GST	Ser881-Glu920	Inquiry
Human	BCLAF1-3495H	Recombinant Human BCLAF1 protein, His-tagged	E.coli	His	881-920 aa	$319 / 25μg
Mouse	BCLAF1-2358M	Recombinant Mouse BCLAF1 Protein	Mammalian Cell	His		Inquiry
Mouse	BCLAF1-1003M	Recombinant Mouse BCLAF1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	BCLAF1-1003M-B	Recombinant Mouse BCLAF1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

BCLAF1 involved in several pathways and played different roles in them. We selected most pathways BCLAF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BCLAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

BCLAF1 has several biochemical functions, for example, DNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCLAF1 itself. We selected most functions BCLAF1 had, and list some proteins which have the same functions with BCLAF1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	IRX2A;NKX1.2LB;SATB1A;FAM170A;ZNF280A;RAG1;RBFOX3;DLX2B;NFE2L2A
poly(A) RNA binding	NOVA2;ZFML;RP9;RPUSD3;FLYWCH2;NOL10;HIST4H4;RPS26;NKAP
protein binding	OOEP;KCNN4;CDK20;NIPSNAP1;C14orf135;CD226;GOSR2;GDI2;PXMP4

BCLAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCLAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCLAF1.

SNW1; THRAP3; EMD; YWHAG; SNIP1; BCL2

Gene Family

Research Area

Tanaka, T; Shibazaki, A; et al. HSP70 mediates degradation of the p65 subunit of nuclear factor kappa B to inhibit inflammatory signaling. SCIENCE SIGNALING 7:-(2014).

Tsui, KH; Lin, LT; et al. Gene expression of cumulus cells in women with poor ovarian response after dehydroepiandrosterone supplementation. Taiwanese Journal of Obstetrics & Gynecology 53:559-565(2014).