BIRC6
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Official Full Name
baculoviral IAP repeat containing 6
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Background
Apollon (Q9NR09) is a ~500 kDa membrane associated inhibitor of apoptosis (IAP) protein. It encodes baculoviral-IAP-repeat (BIR) and ubiquitin-conjugating enzyme (UBC) domains at the N and C-termini, respectively. Unlike other IAPs Apollon encodes a chimeric E2/E3 ubiquitin ligase and is essential for inhibition of apoptosis in certain cell lines. Apollon inhibits apoptosis by promoting ubiquitination and degradation of active Smac and caspase-9, but Apollon also binds to and inactivates precursors of caspase-9 and Smac. Inactivation of Apollon also leads to upregulation and nuclear localization of p53,Which results in activation of caspase-2, Bax, and Bak, ultimately leading to mitochondrial apoptosis. -
Synonyms
BIRC6; baculoviral IAP repeat containing 6; baculoviral IAP repeat-containing protein 6; apollon; BRUCE; baculoviral IAP repeat-containing 6; ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon; BIR repeat-containing ubiquitin-conjugating enzyme; FLJ13726; FLJ13786; KIAA1289;
Species | Cat.# | Product name | Source (Host) | Tag | Price |
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Human | BIRC6-1170H | Recombinant Human BIRC6 protein, His-tagged | E.coli | His |
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Human | BIRC6-230H | Recombinant Human BIRC6 Protein, GST-tagged | Wheat Germ | GST |
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