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  • Official Full Name

    baculoviral IAP repeat containing 8

  • Overview

    Protects against apoptosis mediated by BAX.
  • Synonyms

    BIRC8; baculoviral IAP repeat containing 8; ILP2; ILP-2; hILP2; baculoviral IAP repeat-containing protein 8; IAP-like protein 2; baculoviral IAP repeat-containing 8; inhibitor of apoptosis-like protein 2; testis-specific inhibitor of apoptosis;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BIRC8-234H Recombinant Human BIRC8 Protein, GST-tagged Wheat Germ GST
Human BIRC8-10235H Recombinant Human BIRC8, GST-tagged E.coli GST C-term-236a.a.
Human BIRC8-233H Recombinant Human BIRC8 Protein, GST-tagged Wheat Germ GST
Human BIRC8-171HCL Recombinant Human BIRC8 cell lysate N/A
Human BIRC8-1641HF Recombinant Full Length Human BIRC8 Protein, GST-tagged In Vitro Cell Free System GST 236 amino acids
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BIRC8 Related Articles

BIRC8 involved in several pathways and played different roles in them. We selected most pathways BIRC8 participated on our site, such as Apoptosis, Pathways in cancer, Small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pathways in cancerHSP90AB1;Fgf15;FGFR1;WNT5B;ERBB2;AKT1;XIAP;LAMA5;LAMB4
Small cell lung cancerITGB1;APAF1;LAMC2;PTK2;TRAF2;PIK3CB;PIK3R2;TP53;AKT1
Ubiquitin mediated proteolysisUBE2U;UBR5;ANAPC5;UBE2K;UBE3C;CUL1A;KEAP1B;RBX1;TRIP12

BIRC8 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ubiquitin-protein transferase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC8 itself. We selected most functions BIRC8 had, and list some proteins which have the same functions with BIRC8. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase inhibitor activity involved in apoptotic processBIRC7;RPS6KA3;ARRB1;DPEP1;IGF1RB;BIRC5;GAS6;BIRC3;NOL3
ubiquitin-protein transferase activityTRAF5;FBXO11;RNF25;TRAF4B;LNX2B;LRSAM1;TRIM28;RNF141;MARCH8
zinc ion bindingMTA1;MBTD1;RNF133;NR1I3;TRIM67;MT1M;RNF10;FNTB;ATRX

BIRC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC8.


Barathan, M; Gopal, K; et al. Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. APOPTOSIS 20:466-480(2015).
Glodkowska-Mrowka, E; Solarska, I; et al. Differential expression of BIRC family genes in chronic myeloid leukaemia-BIRC3 and BIRC8 as potential new candidates to identify disease progression. BRITISH JOURNAL OF HAEMATOLOGY 164:740-742(2014).
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