BIRC8
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Official Full Name
baculoviral IAP repeat containing 8 -
Overview
Protects against apoptosis mediated by BAX. -
Synonyms
BIRC8;baculoviral IAP repeat containing 8;ILP2;ILP-2;hILP2;baculoviral IAP repeat-containing protein 8;IAP-like protein 2;baculoviral IAP repeat-containing 8;inhibitor of apoptosis-like protein 2;testis-specific inhibitor of apoptosis
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BIRC8-10235H | Recombinant Human BIRC8, GST-tagged | E.coli | Human | GST | C-term-236a.a. | |
| BIRC8-233H | Recombinant Human BIRC8 Protein, GST-tagged | Wheat Germ | Human | GST |
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| BIRC8-234H | Recombinant Human BIRC8 Protein, GST-tagged | Wheat Germ | Human | GST |
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| BIRC8-171HCL | Recombinant Human BIRC8 cell lysate | Human | Non |
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| BIRC8-1641HF | Recombinant Full Length Human BIRC8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 236 amino acids |
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Involved Pathway
BIRC8 involved in several pathways and played different roles in them. We selected most pathways BIRC8 participated on our site, such as Apoptosis,Pathways in cancer,Small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | CTNNA3,IGF1R,FGF10,APC,FGF12,CSF1R,WNT3A,BMP2,PTGER2,FGF5 |
| Small cell lung cancer | LAMB1,ITGAV,COL4A1,APAF1,RXRG,TRAF3,XIAP,BIRC2,NOS2,LAMA2 |
| Ubiquitin mediated proteolysis | ITCH,UBE2E1,TRIM32,UBE2H,FZR1,UBE2QL1,UBE2F,FBXW7,TRIP12,UBE2L3 |
| Apoptosis | PIK3CA,DBNLB,IRF2,Casp3,CAPN1,PPP3R2,PRKACAA,CASP8,TNFSF10,IRAK2 |
| Toxoplasmosis | TAB2,MAPK13,Toxoplasma Gondii Dense Granule Protein 7,BIRC3,HLA-DPA1,HSPA8,HSPA1A,HLA-DQA1,MAP2K6,AKT2 |
Protein Function
BIRC8 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process,ubiquitin-protein transferase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC8 itself. We selected most functions BIRC8 had, and list some proteins which have the same functions with BIRC8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | SIRT5,AJUBA,ZNF276,ZCCHC3,ADAM21,TADA2A,PHF1,ZDHHC5,TRIM42,TET2 |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | SERPINB9,NAIP1,RPS6KA3,ARRB1,GAS6,XIAP,BIRC2,VIL1,SNCA,PRDX5 |
| ubiquitin-protein transferase activity | RBCK1,RC3H2,SMURF2,MALT1,PEX2,HECW2,ZNF738,UBE2L3,PRKCQ,UBE2R2 |
Interacting Protein
BIRC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC8.
HIP2;UBE2D1;UBE2E1;UBE2D3;UBE2N;UBE2D2;UBE2V1;UBE2W;UBE2D4
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References
- Barathan, M; Gopal, K; et al. Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. APOPTOSIS 20:466-480(2015).
- Glodkowska-Mrowka, E; Solarska, I; et al. Differential expression of BIRC family genes in chronic myeloid leukaemia-BIRC3 and BIRC8 as potential new candidates to identify disease progression. BRITISH JOURNAL OF HAEMATOLOGY 164:740-742(2014).
