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BIRC8

Official Full Name

baculoviral IAP repeat containing 8
Overview

Protects against apoptosis mediated by BAX.
Synonyms

BIRC8; baculoviral IAP repeat containing 8; ILP2; ILP-2; hILP2; baculoviral IAP repeat-containing protein 8; IAP-like protein 2; baculoviral IAP repeat-containing 8; inhibitor of apoptosis-like protein 2; testis-specific inhibitor of apoptosis;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BIRC8-234H	Recombinant Human BIRC8 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BIRC8-10235H	Recombinant Human BIRC8, GST-tagged	E.coli	GST	C-term-236a.a.	$319 / 25ug
Human	BIRC8-233H	Recombinant Human BIRC8 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BIRC8-171HCL	Recombinant Human BIRC8 cell lysate		N/A		Inquiry
Human	BIRC8-1641HF	Recombinant Full Length Human BIRC8 Protein, GST-tagged	In Vitro Cell Free System	GST	236 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

BIRC8 involved in several pathways and played different roles in them. We selected most pathways BIRC8 participated on our site, such as Apoptosis, Pathways in cancer, Small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Apoptosis	HIST1H1A;PRKAR2AA;BIRC5A;PIK3R3;ENDOG;PPP3R2;BIRC2;DBNLA;DSG3
Pathways in cancer	TCF7;RELA;PLCB4;PLCG2;PTK2;NKX3-1;MMP9;CKS2;LPAR6
Small cell lung cancer	TRP53;FN1;TRAF3;APAF1;MAX;ITGA2B;BCL2;ITGA2;PIK3CD
Toxoplasmosis	MAPK8;LAMA1;STAT1;PIK3R1;ITGB1;GNAI3;IRGM;HLA-DRA;PIK3CD
Ubiquitin mediated proteolysis	TCEB2;UBE2K;UBE2J1;UBE2H;UBE2Q1;UBE2D2A;FBXW11B;RBX1;HERC4

BIRC8 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ubiquitin-protein transferase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC8 itself. We selected most functions BIRC8 had, and list some proteins which have the same functions with BIRC8. You can find most of the proteins on our site.

Function	Related Protein
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	MT3;DPEP1;BIRC5;C1QL4L;BIRC3;NAIP1;TFAP2B;PRDX5;SERPINB1A
ubiquitin-protein transferase activity	UBE3C;RNF135;TRAF7;UBA7;UBR1;FBXO22;RNF38;FEM1B;LNX2B
zinc ion binding	TRIM35-20;MT2A;DNMT5;BRF2;MID2;SOD3A;ZDHHC13;ADAM15;LMO7A

BIRC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC8.

HIP2; UBE2D1; UBE2E1; UBE2D3; UBE2N; UBE2D2; UBE2V1; UBE2W; UBE2D4

Research Area

Barathan, M; Gopal, K; et al. Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. APOPTOSIS 20:466-480(2015).

Glodkowska-Mrowka, E; Solarska, I; et al. Differential expression of BIRC family genes in chronic myeloid leukaemia-BIRC3 and BIRC8 as potential new candidates to identify disease progression. BRITISH JOURNAL OF HAEMATOLOGY 164:740-742(2014).