KIT
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Official Full Name
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
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Overview
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT; SCFR; C-Kit; CD117; mast/stem cell growth factor receptor Kit; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chromatography Reagents
- Chicken
- Dog
- Human
- Mouse
- Rat
- Rhesus
- Rhesus Macaque
- Rhesus monkey
- CHO
- E.coli
- HEK293
- Human Cell
- Human Cells
- Insect cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- C
- hFc
- His
- DDK
- DDK|His
- DYKDDDDK
- Fc
- Fc|His
- His(C
- ter)
- Flag
- GST
- hIgG1
- hIgG4
- His (Fc)
- Avi
- His|GST
- His|T7
- human|IgG1|Fc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- KIT Related Research Area
KIT involved in several pathways and played different roles in them. We selected most pathways KIT participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ras signaling pathway | PLA2G5;RAF1;RALB;AKT2;KRAS;PIK3CD;GNG10;ETS1;GRIN2B |
Rap signaling pathway | MAPK12;RALB;IGF1;GNAI3;FGF11;APBB1IP;ID1;GRIN2A;GNAI1 |
Cytokine-cytokine receptor interaction | IFNB;CXCL13;IRX1;CXCR3;TNFSF13B;KITLG;Ifna11;CCR9;ACVR1L |
Phospholipase D signaling pathway | INS1;PLA2G4D;PLD2;PIK3R5;PIK3R1;GNAS;AVPR1B;PDGFD;SYK |
Endocytosis | ZFYVE16;HGS;VPS26B;FAM125A;WIPF2B;ERBB4A;HLA-E;CHMP6;ERBB3B |
PIK-Akt signaling pathway | CCND3;IGF1;PPP2R3A;IFNA13;PDGFC;KLK1B4;PPP2R1B;CREB5;GNG2 |
Hematopoietic cell lineage | ITGB3;IL4R;Il6ra;CD59A;IL2RA;CD1E, B2M;CD1A;KIT;Itga10&Itgb1 |
Melanogenesis | WNT9B;CAMK2B;WNT7A;PRKACBA;GNAI2A;Adcy4;WNT11;GNAS;DVL3A |
Pathways in cancer | LAMB3;WNT1;IL6;LAMA4;RARB;SFPI1;Casp3;GNG12;LAMB1 |
Acute myeloid leukemia | STAT5A;SFPI1;MAPK3;STAT5B;RUNX1;MAP2K2;RUNX1T1;PIM2;PIM1 |
Central carbon metabolism in cancer | G6PDX;TRP53;PDGFRA;HRAS;SLC16A3;PDGFRB;FGFR2;SLC1A5;PGAM2 |
KIT has several biochemical functions, for example, ATP binding, cytokine binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIT itself. We selected most functions KIT had, and list some proteins which have the same functions with KIT. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | CAMKK1A;DHX57;GLYCTK;EPHA6;CSNK1G2B;ATAD5B;ULK2;ABCB7;ATAD5 |
cytokine binding | KIT;IL17F;CRLF1;CSF1RA;Fzd4;GBP1;LIFR;NOG;CHRD |
metal ion binding | CNOT4B;RNF148;SOBP;CTDSP2;TGM2A;GALNT13;LMX1BB;FCER2;PAK3 |
protease binding | LDLR;A2M;HSPA6;ADAM8A;TRIP4;CNTNAP2;PINK1;POLG;SERPINB3 |
protein binding | KRAS;VIL1;RAD1;YWHAB;ARL11;SPAG8;VPS33B;TNFAIP3;SPRR2E |
protein homodimerization activity | Il6ra;RRAGA;HHEX;KCNE2;RNF17;ZFP652;CBX1;PARK7;TREX2 |
protein tyrosine kinase activity | PTK2;LTK;Fert2;JAK2;CSF1RA;MET;LCK;JAK2A;MAP2K6 |
receptor signaling protein tyrosine kinase activity | SYK;LYN;EGFR;EGFRA;KITA;ERBB3B;KITB;INSR;ERBB4A |
stem cell factor receptor activity | |
transmembrane receptor protein tyrosine kinase activity | ERBB4A;FGFR1A;RYK;ERBB3B;EGFRA;MERTK;PDGFRA;MUSK;EPHB4A |
KIT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIT here. Most of them are supplied by our site. Hope this information will be useful for your research of KIT.
PIK3R1; GRB2
- Q&As
- Reviews
Q&As (5)
Ask a questionKIT expression varies across tissues due to tissue-specific transcription factors, epigenetic modifications, and microenvironmental cues influencing its regulation.
Transcription factors like PU.1 and GATA-2, along with epigenetic modifications, regulate KIT gene expression.
KIT is crucial for germ cell survival and proliferation; mutations may lead to infertility.
KIT maintains and influences stem cell behavior, holding potential in regenerative medicine.
KIT is vital in hematopoietic stem cell development; mutations link to leukemia and mastocytosis.
Customer Reviews (3)
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