CA3
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Official Full Name
carbonic anhydrase III, muscle specific
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Overview
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. -
Synonyms
CA3; carbonic anhydrase III, muscle specific; carbonic anhydrase 3; CAIII; Car3; CA-III; carbonate dehydratase III; FLJ36434; Car-3; BB219044;
- Recombinant Proteins
- Cell & Tissue Lysates
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- His
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- Involved Pathway
- Protein Function
- Interacting Protein
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CA3 involved in several pathways and played different roles in them. We selected most pathways CA3 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitrogen metabolism | Car2;CA14;CAR15;CAR3;GLUL;GLUD2;CAR5A;CA12;CA6 |
CA3 has several biochemical functions, for example, carbonate dehydratase activity, nickel cation binding, phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CA3 itself. We selected most functions CA3 had, and list some proteins which have the same functions with CA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbonate dehydratase activity | Car12;CA9;CA5A;CA4;CA5;CA4B;CA13;Car2;CA8 |
| nickel cation binding | CA3;P2RX2;CAR3;SLC11A2 |
| phosphatase activity | DUSP11;C12orf5;MTMR1B;DUSP23B;STYX;PTPN4B;TIGARA;ALPI.2;DUSP3B |
| zinc ion binding | RNF146;NR5A5;CNBP;CREBBP;RGN;UBR5;PDZRN4;CLIP1;PAPPA |
CA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA3.
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Q&As (7)
Ask a questionCA3 is primarily found in skeletal muscles.
Post-translational modifications, like phosphorylation or glycosylation, can be identified using mass spectrometry.
Specific inhibitors for CA3 are yet to be fully elucidated and would be determined using enzymatic assays.
CA3 plays a role in CO2 and bicarbonate equilibrium, crucial for metabolic pathways like glycolysis and the citric acid cycle.
While CA3 has a similar mechanism, its activity and affinity might differ from other isoforms, requiring comparative studies.
CA3 dysregulation might be linked to muscle diseases or metabolic disorders, requiring further research.
CA3 catalyzes the reversible hydration of carbon dioxide, aiding in pH regulation and CO2 transport.
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