CA3

  • Official Full Name

    carbonic anhydrase III, muscle specific

  • Overview

    Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns.
  • Synonyms

    CA3; carbonic anhydrase III, muscle specific; carbonic anhydrase 3; CAIII; Car3; CA-III; carbonate dehydratase III; FLJ36434; Car-3; BB219044;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Strep
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CA3-35H Recombinant Human carbonic anhydrase III, muscle specific, His-tagged E.coli His
Human CA3-1143H Active Recombinant Human CA3 protein, His-tagged E.coli His Met1-Lys260
Human CA3-27266TH Recombinant Human CA3 E.coli N/A
Human CA3-1239H Recombinant Human Carbonic Anhydrase III, Muscle Specific Human N/A
Human CA3-27267TH Recombinant Human CA3, His-tagged E.coli His
Human CA3-0239H Recombinant Human CA3 Protein, GST-Tagged Wheat Germ GST
Human CA3-10620H Recombinant Human CA3, His-tagged E.coli His 1-260a.a.
Human CA3-7914HCL Recombinant Human CA3 293 Cell Lysate HEK293 N/A
Human CA3-2736HF Recombinant Full Length Human CA3 Protein, GST-tagged In Vitro Cell Free System GST 260 amino acids
Human CA3-1051H Recombinant Human CA3 Protein (M1-K260), His/Strep tagged E.coli His/Strep M1-K260
Human CA3-301614H Recombinant Human CA3 protein, GST-tagged E.coli GST Met1-Lys260
Human CA3-3283H Recombinant Human CA3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CA3-926HFL Recombinant Full Length Human CA3 Protein, C-Flag-tagged Mammalian cells Flag
Human CAB11487MH Mouse Anti-Human Carbonic Anhydrase III, Muscle Specific Monoclonal Antibody Mouse N/A
Human CA3-1050H Recombinant Human CA3 Protein (M1-K260), Tag Free E.coli No tag M1-K260
Human CA3-480H Recombinant Human CA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CA3-480H-B Recombinant Human CA3 Protein Pre-coupled Magnetic Beads HEK293
Human CA3-0188H Recombinant Human CA3 Protein (Ala2-Lys260), C-His-tagged E.coli C-His Ala2-Lys260
Mouse CAR3-2719M Recombinant Mouse CAR3 Protein Mammalian Cell His
Mouse CA3-1159M-B Recombinant Mouse CA3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Car3-766M Recombinant Mouse Car3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CA3-1159M Recombinant Mouse CA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CAR3-1132R Recombinant Rat CAR3 Protein Mammalian Cell His
Rat Car3-7834R Recombinant Rat Car3 protein, His & T7-tagged E.coli His/T7 Asn27~Val217 (Accession # P14141)
Rat CA3-717R-B Recombinant Rat CA3 Protein Pre-coupled Magnetic Beads HEK293
Rat CA3-717R Recombinant Rat CA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CA3-4815C Recombinant Chicken CA3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CA3 involved in several pathways and played different roles in them. We selected most pathways CA3 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nitrogen metabolismCAR1;GLUD1;GLULA;CA4;Car8;CA6;Car2;Car9;CA4A

CA3 has several biochemical functions, for example, carbonate dehydratase activity, nickel cation binding, phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CA3 itself. We selected most functions CA3 had, and list some proteins which have the same functions with CA3. You can find most of the proteins on our site.

Function Related Protein
carbonate dehydratase activityCA15A;Car14;CAR15;CAR7;CA15C;CAHZ;CA6;CA3;Car2
nickel cation bindingCAR3;P2RX2;CA3;SLC11A2
phosphatase activityDUSP23A;PHOSPHO1;DUSP22B;CTDSPL2A;PTPN20;PPP1CC;CTDNEP1B;PTPRK;PTPREB
zinc ion bindingADAMTS3;BTR22;BIRC2;RXRBA;RNF217;SHRPRBCK1R;CA15A;LIMS3;IDE

CA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA3.

Research Area

Related articles

Czeh, B; Varga, ZKK; et al. Chronic Stress Reduces the Number of GABAergic Interneurons in the Adult Rat Hippocampus, Dorsal-Ventral and Region-Specific Differences. HIPPOCAMPUS 25:393-405(2015).
Wang, SY; Liu, JP; et al. Qifu-Yin attenuates AGEs-induced Alzheimer-like pathophysiological changes through the RAGE/NF-kappa B pathway. CHINESE JOURNAL OF NATURAL MEDICINES 12:920-928(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
In which tissues is CA3 expression most prominently observed? 10/22/2022

CA3 is primarily found in skeletal muscles.

What post-translational modifications are characteristic of CA3? 06/23/2022

Post-translational modifications, like phosphorylation or glycosylation, can be identified using mass spectrometry.

Are there known inhibitors that specifically target CA3? 09/19/2021

Specific inhibitors for CA3 are yet to be fully elucidated and would be determined using enzymatic assays.

How does CA3 participate in metabolic processes within the cell? 02/04/2021

CA3 plays a role in CO2 and bicarbonate equilibrium, crucial for metabolic pathways like glycolysis and the citric acid cycle.

How does CA3 enzymatic activity differ from other carbonic anhydrase isoforms? 10/26/2019

While CA3 has a similar mechanism, its activity and affinity might differ from other isoforms, requiring comparative studies.

Are there any pathological conditions directly linked to CA3 dysregulation? 06/08/2017

CA3 dysregulation might be linked to muscle diseases or metabolic disorders, requiring further research.

What is the primary physiological role of CA3 in cells? 05/26/2017

CA3 catalyzes the reversible hydration of carbon dioxide, aiding in pH regulation and CO2 transport.

Customer Reviews (3)

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Reviews
09/23/2022

    Outstanding protein sequencing capabilities, unrivaled accuracy.

    05/23/2022

      Precise purification techniques, yield exceptional samples.

      05/25/2021

        Efficient sample handling, optimizes our laboratory workflow.

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