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Recombinant Human CA3

Cat.No. : CA3-27266TH
Product Overview : Recombinant full length Carbonic Anhydrase III protein (Human)
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Description : Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns.
Source : E. coli
Tissue specificity : Muscle specific.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the alpha-carbonic anhydrase family.
Gene Name : CA3 carbonic anhydrase III, muscle specific [ Homo sapiens ]
Official Symbol : CA3
Synonyms : CA3; carbonic anhydrase III, muscle specific; carbonic anhydrase 3; CAIII; Car3;
Gene ID : 761
mRNA Refseq : NM_005181
Protein Refseq : NP_005172
MIM : 114750
Uniprot ID : P07451
Chromosome Location : 8q21.2
Pathway : Nitrogen metabolism, organism-specific biosystem; Nitrogen metabolism, conserved biosystem;
Function : carbonate dehydratase activity; lyase activity; metal ion binding; nickel ion binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In which tissues is CA3 expression most prominently observed? 10/22/2022

CA3 is primarily found in skeletal muscles.

What post-translational modifications are characteristic of CA3? 06/23/2022

Post-translational modifications, like phosphorylation or glycosylation, can be identified using mass spectrometry.

Are there known inhibitors that specifically target CA3? 09/19/2021

Specific inhibitors for CA3 are yet to be fully elucidated and would be determined using enzymatic assays.

How does CA3 participate in metabolic processes within the cell? 02/04/2021

CA3 plays a role in CO2 and bicarbonate equilibrium, crucial for metabolic pathways like glycolysis and the citric acid cycle.

How does CA3 enzymatic activity differ from other carbonic anhydrase isoforms? 10/26/2019

While CA3 has a similar mechanism, its activity and affinity might differ from other isoforms, requiring comparative studies.

Are there any pathological conditions directly linked to CA3 dysregulation? 06/08/2017

CA3 dysregulation might be linked to muscle diseases or metabolic disorders, requiring further research.

What is the primary physiological role of CA3 in cells? 05/26/2017

CA3 catalyzes the reversible hydration of carbon dioxide, aiding in pH regulation and CO2 transport.

Customer Reviews (3)

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Reviews
09/23/2022

    Outstanding protein sequencing capabilities, unrivaled accuracy.

    05/23/2022

      Precise purification techniques, yield exceptional samples.

      05/25/2021

        Efficient sample handling, optimizes our laboratory workflow.

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