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CABLES1

Official Full Name

Cdk5 and Abl enzyme substrate 1
Overview

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Synonyms

CABLES1; Cdk5 and Abl enzyme substrate 1; CABL1; IK3-1; CABLES; HsT2563; CDK5 and ABL1 enzyme substrate 1; interactor with CDK3 1;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E.coli
In Vitro Cell Free System
Mammalian Cell
Sf9 Insect Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CABLES1-1361H	Active Recombinant Human ABL1, GST-tagged	Sf9 Insect Cell	GST	27 aa-end	Inquiry
Human	CABLES1-0256H	Recombinant Human CABLES1 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CABLES1-267HCL	Recombinant Human CABLES1 cell lysate		N/A		Inquiry
Human	CABLES1-2263H	Recombinant Human CABLES1 Protein, His-tagged	E.coli	His		Inquiry
Human	CABLES1-2762HF	Recombinant Full Length Human CABLES1 Protein, GST-tagged	In Vitro Cell Free System	GST	368 amino acids	Inquiry
Zebrafish	CABLES1-6024Z	Recombinant Zebrafish CABLES1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CABLES1 involved in several pathways and played different roles in them. We selected most pathways CABLES1 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CABLES1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Factors involved in megakaryocyte development and platelet production	HBBE2;HBG1;MYB;HBG2;HMG20B;KIF22;OSTN;DOCK6;H3F3D
Hemostasis	HBE1;KIF5B;F9B;SH2B3;ATP2B3A;DGKB;AASS;GATA2;HRG

CABLES1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CABLES1 itself. We selected most functions CABLES1 had, and list some proteins which have the same functions with CABLES1. You can find most of the proteins on our site.

Function	Related Protein
protein binding	RBM10;ACP1;QARS;B9D2;LRRK1;PACSIN3;COPS8;ZNF124;JUB

CABLES1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CABLES1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CABLES1.

CDK5; TP63; TP53; ALB