CACNA1D Protein


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Official Full Name Calcium Channel, Voltage-Dependent, L Type, Alpha 1D Subunit
Background Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarisation. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Voltage-gated calcium channels are formed from four or five distinct subunits; the alpha-subunit is the largest subunit and incorporates the voltage sensor, conduction pore and gating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types of voltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families. Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activateddihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type).
Synonyms Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit; C79217; Cchl1a; D-LTCC; Cchl1a2; Cacnl1a2; 8430418G19Rik; voltage-dependent L-type calcium channel subunit alpha-1D; alpha 1 E; Cav1.3alpha1; calcium channel, L type, alpha-1 polypeptide; voltage-gated calcium channel subunit alpha Cav1.3
    • Species :
    • Chicken
    • Human
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • N-His&GST
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CACNA1D-352H Recombinant Human CACNA1D Protein, His&GST-tagged E.coli N-His&GST
    Rat CACNA1D-1062R Recombinant Rat CACNA1D Protein Mammalian Cell His
    Chicken CACNA1D-6591C Recombinant Chicken CACNA1D Mammalian Cell His

    CACNA1D involved in several pathways and played different roles in them. We selected most pathways CACNA1D participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP3K4; PPM1AB; RASA1; SRF; PLA2G4C; ZAK; RPS6KAL; RPS6KA2; HSPA8; FAS
    Calcium signaling pathway CHRM2; EDNRAA; ADRB3A; STIM1; SLC25A31; SLC25A4; TNNC1A; AGTR1B; PPP3CA; ATP2B1A
    Cardiac muscle contraction TMEM8C; ATP1A3B; COX7A3; UQCRH; VMHCL; FXYD2; CACNB1; COX4I1; UQCR10; TPMA
    Adrenergic signaling in cardiomyocytes PLCB2; SCN1BB; CALM; PIK3R2; CACNA1C; PLCB3; CACNA2D1; MAPK14; SCN1B; ADCY2B
    Vascular smooth muscle contraction PPP1R14AA; PPP1R12A; ADORA2AA; CACNA1C; CALM1B; NPR1; PLA2G2F; GNA11; ROCK2B; PLA2G4D
    GnRH signaling pathway GNRH2; RAF1B; PLA2G4D; CACNA1SA; MAPK11; CDC42L; MAPK1; MAP2K1; RAF1A; PTK2B

    CACNA1D has several biochemical functions, for example, metal ion binding, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1D itself. We selected most functions CACNA1D had, and list some proteins which have the same functions with CACNA1D. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding PRICKLE1B; MFNG; ZBTB33; TNNI1; HDAC9; KLF8; BRCC3; LMX1BA; MGRN1B; ACAP3
    voltage-gated calcium channel activity CACNG8A; CACNB3A; CACNB2; TMC1; CACNA1BA; CACNA1C; CACNG2; ATP6V0CB; CACNB1; CACNG6

    CACNA1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1D here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1D.

    Romero, PJ; Romero, EA; et al. Voltage-dependent calcium channels in young and old human red cells. CELL BIOCHEMISTRY AND BIOPHYSICS 46:265-276(2006).
    Cohen, RM; Foell, JD; et al. Unique modulation of L-type Ca2+ channels by short auxiliary beta(1d) subunit present in cardiac muscle. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 288:H2363-H2374(2005).

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