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Official Full Name calcium channel, voltage-dependent, alpha 2/delta subunit 3
Background This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms CACNA2D3; calcium channel, voltage-dependent, alpha 2/delta subunit 3; voltage-dependent calcium channel subunit alpha-2/delta-3; HSA272268; calcium channel alpha2-delta3 subunit; voltage-gated calcium channel subunit alpha-2/delta-3; calcium channel, vol
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CACNA2D3-10636H Recombinant Human CACNA2D3, GST-tagged E.coli GST
    Human CACNA2D3-7904HCL Recombinant Human CACNA2D3 293 Cell Lysate HEK293 N/A
    Mouse CACNA2D3-2617M Recombinant Mouse CACNA2D3 Protein Mammalian Cell His
    Rat CACNA2D3-1067R Recombinant Rat CACNA2D3 Protein Mammalian Cell His

    cacna2d3 involved in several pathways and played different roles in them. We selected most pathways cacna2d3 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with cacna2d3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PPM1NA; NRAS; NR4A1; FGF21; GADD45BB; PRKACAA; SRF; MAP4K4; CACNA2D4; PLA2G4D
    Cardiac muscle contraction ATP1A3B; CACNB2A; UQCRH; CACNG2; TNNT2; TPM3; TPMA; COX8A; ATP1A3A; ATP1A4
    Adrenergic signaling in cardiomyocytes PIK3CB; CACNA1C; CALM3B; MAPK13; PPP2R2C; ADRB2B; RAPGEF4; PPP2R1B; TPM2; MYL2B
    Oxytocin signaling pathway PPP3R1; MYLK; NPR1; PIK3CB; GNAI3; ROCK1; CACNG6; ELK1; GUCY1A3; KCNJ14
    Hypertrophic cardiomyopathy (HCM) TNNI3; SLC8A1; CACNB1; CACNG8; SGCG; ITGA6; ITGA8; CACNA2D3; PRKAG1; ITGA4
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) CACNG2; ITGA1; ITGA4; ACTN2; LEF1; SGCD; CACNG4; TCF7; ACTN1; PKP2
    Dilated cardiomyopathy ITGB8; GNAS; ADRB1; ITGA6; ITGA1; ITGA9; SGCA; IGF1; SGCG; ATP2A2

    cacna2d3 has several biochemical functions, for example, calcium channel activity, calcium channel regulator activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cacna2d3 itself. We selected most functions cacna2d3 had, and list some proteins which have the same functions with cacna2d3. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel activity CACNA2D3; CACNA1SA; SLC24A4A; TRPV2; TRPN1; SLC24A1; P2RX1; TRPV1; CACNG7A; CACNG8A
    calcium channel regulator activity NRXN3; SGK2A; TSPAN13; NRXN1; PLN; CACNA2D1; SGK3; STIM1A; CAV3; STIM1B
    metal ion binding BMI1A; GALNTL1; CAR15; FIBCD1; POLR2B; MKRN4; MYLK; ASAP3; TM9SF1; SP5
    voltage-gated ion channel activity KCNC3A; KCNH5; CACNA1C; SCN8AB; CLIC1; NALCN; KCNA6A; CACNA1SA; KCNJ1A.5; KCNV2B

    cacna2d3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cacna2d3 here. Most of them are supplied by our site. Hope this information will be useful for your research of cacna2d3.


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