CACNA2D3
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Official Full Name
calcium channel, voltage-dependent, alpha 2/delta subunit 3 -
Overview
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. -
Synonyms
CACNA2D3;calcium channel, voltage-dependent, alpha 2/delta subunit 3;voltage-dependent calcium channel subunit alpha-2/delta-3;HSA272268;calcium channel alpha2-delta3 subunit;voltage-gated calcium channel subunit alpha-2/delta-3;calcium channel, vol
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CACNA2D3-10636H | Recombinant Human CACNA2D3, GST-tagged | E.coli | Human | GST | C-term-305a.a. | |
| CACNA2D3-1067R | Recombinant Rat CACNA2D3 Protein | Mammalian Cells | Rat | His |
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| CACNA2D3-2617M | Recombinant Mouse CACNA2D3 Protein | Mammalian Cells | Mouse | His |
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| CACNA2D3-7904HCL | Recombinant Human CACNA2D3 293 Cell Lysate | HEK293 | Human | Non |
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| CACNA2D3-1172M | Recombinant Mouse CACNA2D3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| CACNA2D3-1172M-B | Recombinant Mouse CACNA2D3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CACNA2D3-731R | Recombinant Rat CACNA2D3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| CACNA2D3-731R-B | Recombinant Rat CACNA2D3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
CACNA2D3 involved in several pathways and played different roles in them. We selected most pathways CACNA2D3 participated on our site, such as MAPK signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA2D3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophic cardiomyopathy (HCM) | ITGB1,SGCD,TNNI3,ITGA9,IGF1,ITGB3,ITGB8,ACTG1,CACNB1,TPM2 |
| Adrenergic signaling in cardiomyocytes | CACNB4,CREB3L4,GNAI1,ADRB2B,CALM2,PIK3CA,PPP2R2CA,AKT2L,PPP2R2A,MAPK13 |
| MAPK signaling pathway | ARRB2,MAP2K4A,CDC42L2,FGF21,PPM1BA,Casp3,PLA2G4F,NGF,GRB2,MAP3K14 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGB8,ITGA10,AASS,ITGB5,ITGA1,DSG2,CACNB3,TCF7L2,DSP,GJA1 |
| Oxytocin signaling pathway | NRAS,CALM2,RGS2,MYLK3,MAP2K1,RAF1,MAPK3,PLA2G4D,CAMK1G,PRKAB2 |
| Dilated cardiomyopathy | CACNA2D1,PRKACA,TNNC1,CACNG1,ITGA3,TPM4,ITGB8,TGFB2,TPM1,MYBPC3 |
| Cardiac muscle contraction | CACNG4,ATP1B4,UQCRQ,TPMA,VMHC,ATP1A1A.1,CACNG6,CACNG6A,SLC8A1,COX5B |
Protein Function
CACNA2D3 has several biochemical functions, for example, calcium channel activity,calcium channel regulator activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA2D3 itself. We selected most functions CACNA2D3 had, and list some proteins which have the same functions with CACNA2D3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium channel regulator activity | GRM3,CAV3,SGK2A,NRXN2,CACNB2,PLN,CACNA2D1A,SGK3,TSPAN13B,STIM1B |
| voltage-gated ion channel activity | KCNG4A,CACNA1C,KCNK4,CATSPER2,KCNIP3,KCNJ11L,KCNJ2A,KCNJ1A.5,CACNA1DA,CLIC5 |
| calcium channel activity | CACNG8A,RYR1B,TRPC3,TRPV6,TRPM4,MCU,CATSPER2,TRPV4,TMEM37,TRPV5 |
| metal ion binding | GNAT1,PPM1NB,ACY1,CADPS,CSH2,CYCS,SDF4,ACMSD,SMAD4,CYP4T8 |
Interacting Protein
CACNA2D3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA2D3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA2D3.
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