Recombinant Human CACNA2D3, GST-tagged

• Cat.No.: CACNA2D3-10636H
• Product Overview: Recombinant Human CACNA2D3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: C-term-305a.a.
• Description: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 [ Homo sapiens ]
• Official Symbol: CACNA2D3
• Synonyms: CACNA2D3; calcium channel, voltage-dependent, alpha 2/delta subunit 3; voltage-dependent calcium channel subunit alpha-2/delta-3; HSA272268; calcium channel alpha2-delta3 subunit; voltage-gated calcium channel subunit alpha-2/delta-3; calcium channel, voltage-dependent, alpha 2/delta 3 subunit
• Gene ID: 55799
• mRNA Refseq: NM_018398
• Protein Refseq: NP_060868
• MIM: 606399
• UniProt ID: Q8IZS8
• Chromosome Location: 3p21.1
• Pathway: Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem
• Function: metal ion binding; voltage-gated calcium channel activity; voltage-gated ion channel activity