CACNG5
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Official Full Name
calcium channel, voltage-dependent, gamma subunit 5
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Overview
The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. -
Synonyms
CACNG5; calcium channel, voltage-dependent, gamma subunit 5; voltage-dependent calcium channel gamma-5 subunit; CACNG 5; Calcium channel voltage dependent gamma subunit 5; CCG5_HUMAN; MGC126656; MGC126682; Neuronal voltage gated calcium channel gamma 5 subunit; Neuronal voltage-gated calcium channel gamma-5 subunit; Voltage dependent calcium channel gamma 5 subunit; TARP gamma-5; transmembrane AMPAR regulatory protein gamma-5;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- CACNG5 Related Articles
CACNG5 involved in several pathways and played different roles in them. We selected most pathways CACNG5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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CACNG5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG5 itself. We selected most functions CACNG5 had, and list some proteins which have the same functions with CACNG5. You can find most of the proteins on our site.
| Function | Related Protein |
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CACNG5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNG5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNG5.
- Q&As
- Reviews
Q&As (7)
Ask a questionDysfunctions or mutations in Cacng5 have been implicated in some neurological disorders, though more extensive research is needed for specific correlations.
Cacng5 mainly interacts with the alpha-1 subunit of calcium channels, and potential associations with other proteins in the channel complex might exist.
Cacng5 acts as an auxiliary subunit, aiding in the modulation of activity, trafficking, and surface expression of voltage-gated calcium channels.
Techniques such as mass spectrometry might be used to identify potential post-translational modifications on Cacng5.
Cacng5 is primarily expressed in neural tissues, especially in specific regions of the brain.
Genetic changes in the Cacng5 gene can alter its regulatory influence on calcium channels, potentially impacting neural signaling and other related processes.
Cacng5 can affect the channel's gating properties, localization, and calcium ion permeation by its binding and modulation.
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