calc1
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Official Full Name
calc1 Calcitonin-1 [ Salmo salar ]
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Overview
Calcitonin (also known as thyrocalcitonin) is a 32-amino acid linear polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). Calcitonin has been found in fish, reptiles, birds, and mammals. Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. It belongs to calcitonin-like protein family. -
Synonyms
calc1; Calcitonin-1;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Salmon | calc1-8308S | Native Salmon calc1 | N/A |
calc1 involved in several pathways and played different roles in them. We selected most pathways calc1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with calc1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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calc1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by calc1 itself. We selected most functions calc1 had, and list some proteins which have the same functions with calc1. You can find most of the proteins on our site.
Function | Related Protein |
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calc1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with calc1 here. Most of them are supplied by our site. Hope this information will be useful for your research of calc1.
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Q&As (5)
Ask a questionThe CALC1 gene encodes three peptide hormones: calcitonin, calcitonin gene-related peptide, and katacalcin. Calcitonin is involved in calcium regulation and also regulates phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and has antimicrobial properties. Katacalcin serves as a calcium-lowering peptide.
Calcitonin is produced from the CALC1 gene (also known as CALCA) through the proteolytic cleavage of a larger prepropeptide. Functionally, calcitonin acts as an antagonist to parathyroid hormone (PTH) and Vitamin D3, playing a role in calcium homeostasis.
Multiple transcript variants encoding different isoforms have been found for the CALC1 gene. This suggests that the gene undergoes tissue-specific alternative RNA splicing and cleavage of inactive precursor proteins, leading to the production of various isoforms with potentially distinct functions or regulatory roles in different tissues or conditions.
The main function of the CT receptors linked to the CALC1 gene is to inhibit bone reabsorption and enhance calcium excretion by the kidneys. This helps regulate calcium levels in the body, particularly by preventing excessive calcium release from bones.
They are GNB1, GNAS, CALCRL, and GNG2
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