CALCRL
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Official Full Name
calcitonin receptor-like
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Overview
CRLR is a receptor for calcitonin gene related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries. -
Synonyms
CALCRL; calcitonin receptor-like; CRLR; CGRPR; calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; calcitonin receptor-like receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Oncorhynchus gorbuscha (Pink salmon) (Salmo gorbuscha)
- Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus)
- Rat
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- Xenopus laevis (African clawed frog)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Flag
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | CALCRL-0298H | Recombinant Human CALCRL Protein | Wheat Germ | N/A |
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| Human | CALCRL-0299H | Recombinant Human CALCRL Protein, GST-Tagged | Wheat Germ | GST |
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| Human | CALCRL-273HCL | Recombinant Human CALCRL cell lysate | N/A |
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| Human | CALCRL-3058HF | Recombinant Full Length Human CALCRL Protein, GST-tagged | In Vitro Cell Free System | GST | 461 amino acids |
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| Human | CALCRL-3057HF | Recombinant Full Length Human CALCRL Protein, GST-tagged | In Vitro Cell Free System | GST | 352 amino acids |
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| Human | CALCRL-1053HFL | Recombinant Human CALCRL protein, His&Flag-tagged | HEK293 | His&Flag | 1-461 aa |
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| Human | CALCRL-1009H | Recombinant Human CALCRL Protein (Glu23-Glu133), N-His tagged | E.coli | N-His | Glu23-Glu133 |
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| Rat | CALCRL-1090R | Recombinant Rat CALCRL Protein | Mammalian Cell | His |
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| Rat | CALCRL-754R | Recombinant Rat CALCRL Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | CALCRL-754R-B | Recombinant Rat CALCRL Protein Pre-coupled Magnetic Beads | HEK293 |
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| Bos taurus (Bovine) | RFL1595BF | Recombinant Full Length Bovine Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (23-462) |
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| Homo sapiens (Human) | RFL32837HF | Recombinant Full Length Human Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (23-461) |
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| Mus musculus (Mouse) | RFL24122MF | Recombinant Full Length Mouse Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (23-463) |
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| Oncorhynchus gorbuscha (Pink salmon) (Salmo gorbuscha) | RFL18563OF | Recombinant Full Length Oncorhynchus Gorbuscha Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (18-465) |
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| Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) | RFL25068PF | Recombinant Full Length Paralichthys Olivaceus Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | His | Full Length (21-465) |
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| Rattus norvegicus (Rat) | RFL21621RF | Recombinant Full Length Rat Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (24-464) |
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| Sus scrofa (Pig) | RFL32613SF | Recombinant Full Length Pig Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (23-462) |
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| Xenopus laevis (African clawed frog) | RFL1126XF | Recombinant Full Length Xenopus Laevis Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (34-476) |
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| Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | RFL35097XF | Recombinant Full Length Xenopus Tropicalis Calcitonin Gene-Related Peptide Type 1 Receptor(Calcrl) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (29-472) |
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| Chicken | CALCRL-3992C | Recombinant Chicken CALCRL | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- CALCRL Related Articles
CALCRL involved in several pathways and played different roles in them. We selected most pathways CALCRL participated on our site, such as Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), Endothelin, which may be useful for your reference. Also, other proteins which involved in the same pathway with CALCRL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcitonin-like ligand receptors | RAMP3;ADM2;CALCRL;CALCB;CALCA;RAMP1;ADM;ADM2A;RAMP2 |
| Class B/2 (Secretin family receptors) | PTH2;RAMP2;CRHB;PTHRP2;PTHLH;CALCRL;GNB5A;PTH;RAMP3 |
| Endothelin | CALCRL;EDN1;ECE1;CALCA;EDNRB;MYL1;EDNRA;CNN1;RAMP1 |
| G alpha (s) signalling events | RAMP3;NPSR1;RAMP1;GPBAR1;CRHR2;PTHLHA;RLN3;CRHR1;ADORA2A |
| GPCR downstream signaling | NTS;OPN1MW;CYSLTR1;NPSR1;OXTRL;CALCB;ANXA1B;OPN1MW2;CHRM3 |
| GPCR ligand binding | HCRT;OPN1LW1;CCR9;RLN3A;GPR17;APLN;ZFPM2B;CCR7;PROKR2 |
| GPCRs, Class B Secretin-like | CD97;CRHR2;LPHN1;ELTD1;EMR1;CRHR1;CALCRL;EMR2;ADCYAP1R1 |
| Neuroactive ligand-receptor interaction | GNRHR2;GRIN3B;DRD2L;GRM2A;OXTR;GRIA1;TAAR14A;CHRNA3;OPRD1A |
CALCRL has several biochemical functions, for example, G-protein coupled receptor activity, adrenomedullin receptor activity, calcitonin gene-related peptide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CALCRL itself. We selected most functions CALCRL had, and list some proteins which have the same functions with CALCRL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | GRM2;CCR12A;VMN1R52;VMN1R44;GPR6;NPY8AR;CCR10;HTR5AL;OPN1MW4 |
| adrenomedullin receptor activity | CALCRL;GPR182 |
| calcitonin gene-related peptide receptor activity | CRCP;CALCRL |
| calcitonin receptor activity | RAMP1;CALCRLA;CALCR;CALCRL |
| protein binding | LAMTOR2;NOV;DHH;AKIP1;KRIT1;TXNDC12;TCF3;EIF3E;JAM3B |
| protein transporter activity | AP1G1;RANGRF;USO1;AP1S3B;TMCO6;AP2A1;COX18;IPO8;ITGB1BP1 |
CALCRL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALCRL here. Most of them are supplied by our site. Hope this information will be useful for your research of CALCRL.
RAMP2; ADM; CALCA; CALCA; RAMP1
- Q&As
- Reviews
Q&As (5)
Ask a questionCALCRL is a G-protein-coupled receptor (GPCR). It interacts with CGRP by binding to it, initiating intracellular signaling pathways.
CALCRL forms a complex with the receptor activity-modifying protein 1 (RAMP1) to create the functional CGRP receptor, allowing CGRP to exert its biological actions.
CALCRL mediates the biological effects of CGRP, which include vasodilation, pain modulation, and inflammation regulation.
Signaling through CALCRL is specific to CGRP. Downstream pathways include activation of cyclic AMP (cAMP) and intracellular calcium levels, influencing vascular tone and pain perception.
Understanding CALCRL's role in CGRP signaling has led to the development of targeted therapies for migraine and chronic pain, making it a significant area of clinical research.
Customer Reviews (3)
Write a reviewI rely on the product for consistent and reproducible outcomes.
The product is an indispensable part of my lab routine.
The timely delivery of the product was a pleasant surprise.
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