calr
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  • Official Full Name
  • calreticulin
  • Background
  • Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CALR; calreticulin; RO; CRT; SSA; cC1qR; HEL-S-99n; CRP55; ERp60; HACBP; grp60; calregulin; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; Sicca syndrome antigen A (autoantigen Ro; calreticulin);
Cat.#:CALR-0313HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CALR Protein, GST-Tagged
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Cat.#:CALR-2288HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CALR Protein, MYC/DDK-tagged
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Cat.#:CALR-27212THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CALR, His-tagged
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Cat.#:CALR-27213THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CALR
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Cat.#:CALR-524HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human CALR protein, His-tagged
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Cat.#:CALR-8593HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CALR, Fc tagged
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Cat.#:CALR-8594HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CALR, His tagged
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Cat.#:CALR-906HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Calreticulin, His-tagged
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Cat.#:Calr-7034MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Calr protein, His-tagged
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Cat.#:CALR-1097RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CALR Protein
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Cat.#:CALR-356CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CALR Protein, His-tagged
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Cat.#:CALR-610RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CALR Protein, His-tagged
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Cat.#:CALR-8675ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CALR
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Cat.#:CALR-2368HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Calreticulin, 18-417 aa, His-tagged
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Cat.#:CALR-2073RTag:N/A
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit Calreticulin
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Cat.#:Calr-1185MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Calreticulin
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Cat.#:CALR-1222HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CALR cell lysate
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CALR Related Articles

Wilhelm, M; Lawrence, JJ; et al. Enteric plexuses of two choline-acetyltransferase transgenic mouse lines: Chemical neuroanatomy of the fluorescent protein-expressing nerve cells. BRAIN RESEARCH BULLETIN 111:76-83(2015).
Vannucchi, AM; Rotunno, G; et al. Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value. LEUKEMIA 28:1811-1818(2014).