CALR Protein


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Official Full Name calreticulin
Background Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
Synonyms CALR; calreticulin; RO; CRT; SSA; cC1qR; HEL-S-99n; CRP55; ERp60; HACBP; grp60; calregulin; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; Sicca syndrome antigen A (autoantigen Ro; calreticulin);
    • Species :
    • Chinese hamster
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cell
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • Flag
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    • SKIK-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CALR-0313H Recombinant Human CALR Protein, GST-Tagged Wheat Germ GST
    Human CALR-2368H Recombinant Human Calreticulin, 18-417 aa, His-tagged E.coli His
    Human CALR-27212TH Recombinant Human CALR, His-tagged E.coli His
    Human CALR-27213TH Recombinant Human CALR E.coli N/A
    Human CALR-524H Recombinant Human CALR protein, His-tagged HEK293F His
    Human CALR-8593H Recombinant Human CALR, Fc tagged Human Cell Fc
    Human CALR-8594H Recombinant Human CALR, His tagged Human Cell His
    Human CALR-906H Recombinant Human Calreticulin, His-tagged E.coli His
    Mouse Calr-1185M Recombinant Mouse Calreticulin E.coli N/A
    Mouse Calr-7034M Recombinant Mouse Calr protein, His-tagged E.coli His
    Rat CALR-1097R Recombinant Rat CALR Protein Mammalian Cell His
    Cynomolgus Monkey CALR-356C Recombinant Cynomolgus CALR Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CALR-610R Recombinant Rhesus monkey CALR Protein, His-tagged Mammalian Cell His
    Rabbit CALR-2073R Recombinant Rabbit Calreticulin E.coli N/A
    Zebrafish CALR-8675Z Recombinant Zebrafish CALR Mammalian Cell His
    Human CALR-1222HCL Recombinant Human CALR cell lysate Human Cell N/A
    Human CALR-06H Recombinant Human CALR Protein E.coli
    Chinese hamster CALR-1433C Recombinant Chinese hamster CALR protein, His-tagged Yeast His
    Mouse Calr-1438M Recombinant Mouse Calr protein, SKIK-His-tagged Yeast SKIK-His
    Human CALR-2625H Recombinant Human CALR protein, GST-tagged E.coli GST
    Human CALR-301231H Recombinant Human CALR protein, GST-tagged E.coli GST
    Human CALR-3078HF Recombinant Full Length Human CALR Protein, GST-tagged In Vitro Cell Free System GST
    Mouse Calr-356M Recombinant Mouse Calr Protein, His-tagged E.coli N-His
    Rat Calr-357R Recombinant Rat Calr Protein, His-tagged E.coli N-His
    Mouse Calr-5359M Recombinant Mouse Calr protein, His-tagged Yeast His
    Human CALR-90HFL Recombinant Full Length Human CALR Protein, C-Flag-tagged Mammalian cells Flag
    Human CALR-2288H Recombinant Human CALR Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CALR-2764H Recombinant Human CALR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse CALR-377M Recombinant Mouse CALR Protein (18-416 aa), GST-tagged E.coli GST
    Mouse Calr-748M Recombinant Mouse Calr Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Pig CALR-2130P Recombinant Pig CALR Protein (18-417 aa), His-tagged Yeast His

    CALR involved in several pathways and played different roles in them. We selected most pathways CALR participated on our site, such as Protein processing in endoplasmic reticulum, Phagosome, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CALR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum MOGS; HSPBP1; SEC24C; RRBP1A; RAD23AB; CAPN1B; HSPA6; DNAJC5AA; MAPK10; EIF2AK3
    Antigen processing and presentation HLA-DQA2; CD8B; NFYB; HLA-DOA; PSME2; HLA-DMB; HSPA2; HLA-DRB4; HSPA1B; KIR2DS3
    Chagas disease (American trypanosomiasis) CCL3L1; IL10; TGFB2; GNA14; IL12A; GNAI1; AKT2; GNAI3; IL6; MAPK11
    HTLV-I infection BUB1B; ANAPC2; FZD8; WNT2; POLB; HLA-DRB1; WNT9A; DLG1; Pdgfa&Pdgfb; KRAS

    CALR has several biochemical functions, for example, DNA binding, androgen receptor binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CALR itself. We selected most functions CALR had, and list some proteins which have the same functions with CALR. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HOXB8B; ARID5A; MYCS; ZNF285A; LHX2A; RAD51L3; FANCI; ALX3; ZNF143B; FOXS1
    androgen receptor binding KAT5; RAN; CCNE1; PRKCB; KDM3A; Ar; NCOA1; NCOA3; DDX5; PRKCBB
    calcium ion binding FKBP14; ANXA8; SMOC1; S100P; RHOT2; SLC25A12; MYLPFA; PPP3R2; PLCB1; CAPN2L
    carbohydrate binding WBSCR17; LGALS4; CLEC7A; CNTN1; CDIPT; EVA1C; KLRC4-KLRK1; GALNT1; NCAN; PRG3
    chaperone binding CP; CTSC; DNLZ; DNAJA1; PFDN6; SERPINA7; DNAJC10; DNAJA2; PIH1D3; UBL4
    complement component C1q binding APCS; CRP; C4A; CALR; C1QBP; PTX3; CD93
    glycoprotein binding OS9; ITGAM; STX1A; FLNA; LDLR; Shh; FBXO6; FBXO2; RAB14; VWF
    hormone binding LRP2; MC1R; ADIPOR1A; MTNR1A; MC5R; CRYM; ADIPOR1B; NPR2; UCN2; CALR
    integrin binding ICAM5; ADAM23; COL3A1; NOV; AMICA1; S1PR2; TGFBI; S1PR3; CD9; ILK
    iron ion binding CYP4A11; XDH; PLOD2; EGLN3; TMLHE; CYP3A43; HBBE3; CYP2AA7; CYP2P9; CYP27B1
    mRNA binding UHMK1; DCP1B; MRPS7; PTBP2; CSTF3; NXF2; DHFR; RBM4; DPPA5A; EDC3
    poly(A) RNA binding RPS17; ZNF622; PTBP2; CAPRIN1; RPS26; FASTKD2; TMEM38A; SREK1; CANX; UTP14A
    protein binding TOMM7; CDC7; SMU1; NUAK1; BLOC1S2; CEP72; OOEP; MT3; AOC3; KRTAP5-9
    protein binding involved in protein folding RIC3; PFDN2; HSPA1B; CALR3; PDCL3; CALR; CLGN; PFDN1; DNAJB8; CD74
    ubiquitin protein ligase binding LRPPRC; GPI; FZD8; GABARAPL1; TRP53; SUMO2; ARRB2; SMC6; CDKN1A; DTX1
    unfolded protein binding CCT5; MKKS; PFDN2; HSPE1; CDC37L1; DNAJB6; SYVN1; CRYABA; ERO1LB; TRAP1
    zinc ion binding MAN2B1; SRSF7; LMO3; RXRGA; RNF133; BTY; PHC2; GATAD2B; LHX3; MYLIPA

    CALR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALR here. Most of them are supplied by our site. Hope this information will be useful for your research of CALR.

    GABARAP; APP; HSPB1; TAP1; p29991-pro_0000037946; env; EIF1B; F8; EPB41; CD40

    Wilhelm, M; Lawrence, JJ; et al. Enteric plexuses of two choline-acetyltransferase transgenic mouse lines: Chemical neuroanatomy of the fluorescent protein-expressing nerve cells. BRAIN RESEARCH BULLETIN 111:76-83(2015).
    Vannucchi, AM; Rotunno, G; et al. Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value. LEUKEMIA 28:1811-1818(2014).

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