Recombinant Human CALR Protein

• Cat.No.: CALR-06H
• Product Overview: Recombinant Human CALR Protein was expressed in E. coli.

Specification

• Description: Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.
• Source: E. coli
• Species: Human
• Form: Liquid. In 20 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, pH 8.0, with 10% glycerol.
• Molecular Mass: ~45 kDa
• AA Sequence: MSRWIESKHKSDFGKFVLSSGKFYG DEEKDKGLQTSQDARFYALSASFEP FSNKGQTLVVQFTVKHEQNIDCGGG YVKLFPNSLDQTDMHGDSEYNIMFG PDICGPGTKKVHVIFNYKGKNVLIN KDIRCKDDEFTHLYTLIVRPDNTYE VKIDNSQVESGSLEDDWDFLPPKKI KDPDASKPEDWDERAKIDDPTDSKP EDWDKPEHIPDPDAKKPEDWDEEMD GEWEPPVIQNPEYKGEWKPRQIDNP DYKGTWIHPEIDNPEYSPDPSIYAY DNFGVLGLDLWQVKSGTIFDNFLIT NDEAYAEEFGNETWGVTKAAEKQMK DKQDEEQRLKEEEEDKKRKEEEEAE DKEDDEDKDEDEEDEEDKEEDEEED VPGQAKDEL
• Endotoxin: <1 EU/ug as determined by LAL method.
• Purity: >90%
• Storage: Short Term Storage at 4 centigrade, Long Term, please prepare aliquots with 20% glycerol and store at -20 to -80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.17 mg/ml
• Official Full Name: Calreticulin

Gene Information

• Gene Name: CALR calreticulin [ Homo sapiens (human) ]
• Official Symbol: CALR
• Synonyms: RO; CRT; SSA; cC1qR; HEL-S-99n
• Gene ID: 811
• mRNA Refseq: NM_004343
• Protein Refseq: NP_004334
• MIM: 109091
• UniProt ID: P27797