CAV2

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CAV2

Official Full Name caveolin 2
Background The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
Synonyms CAV2; caveolin 2; CAV; caveolin-2; caveolae protein, 20-kD; caveolin 2 isoform a and b;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAV2-0448H Recombinant Human CAV2 Protein, GST-Tagged Wheat Germ GST
    Human CAV2-10750H Recombinant Human CAV2, His-tagged E.coli His
    Human CAV2-26609TH Recombinant Human CAV2 Wheat Germ N/A
    Human CAV2-508H Recombinant Human CAV2 Mammalian Cell His
    Human CAV2-7820HCL Recombinant Human CAV2 293 Cell Lysate HEK293 N/A
    Mouse CAV2-2774M Recombinant Mouse CAV2 Protein Mammalian Cell His
    Mouse Cav2-781M Recombinant Mouse Cav2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CAV2-1153R Recombinant Rat CAV2 Protein Mammalian Cell His
    Rhesus Macaque CAV2-635R Recombinant Rhesus monkey CAV2 Protein, His-tagged Mammalian Cell His
    Chicken CAV2-1737C Recombinant Chicken CAV2 Mammalian Cell His
    Zebrafish CAV2-374Z Recombinant Zebrafish CAV2 Mammalian Cell His

    CAV2 involved in several pathways and played different roles in them. We selected most pathways CAV2 participated on our site, such as Endocytosis, Focal adhesion, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAV2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis CLTCB; SH3GLB2A; ARFGEF2; STAMBPB; FGFR3; GRK1; VPS26BL; EHD1; CDC42L; CCDC53
    Focal adhesion PIK3R3A; TNC; Pdgfa&Pdgfb; AKT1; THBS2; SHC1; COL1A1A; COL2A1B; ITGB3; MAPK4
    Bacterial invasion of epithelial cells WAS; BCAR1; WASF2; ELMO2; DNM1; SEPT2; CTNNA1; ITGA5; SHC4; CDC42
    Proteoglycans in cancer HPSE; TGFB2; ARHGEF12; ANK2; STAT3; FZD10; RAC1; CBLB; RPS6KB1; BRAF

    CAV2 has several biochemical functions, for example, D1 dopamine receptor binding, protein binding, protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by CAV2 itself. We selected most functions CAV2 had, and list some proteins which have the same functions with CAV2. You can find most of the proteins on our site.

    Function Related Protein
    D1 dopamine receptor binding DRD3; ATP1A3; ARRB2; CAV2; DLG4; GNAS; AGTR1A; PTPN11
    protein binding FRMD5; PLEK; ENSA; BTBD1; TRIM11; CAMP; MAGEA11; ALX1; DYRK4; IFI35
    protein binding, bridging CSTA; RBM14; TRIM22; ANXA1; TRIM6; FSCN1A; CUX1; NUFIP1; ANK2; SPRR1B
    protein complex scaffold WWC1; CAV2; CAPN3; DLG1; SLC9A3R1; TELO2; MAGI1; MAGI1B; KLHL17; AKAP9
    protein heterodimerization activity HIST2H4A; APITD1; CHUK; KCNA3; SIM1; CHRNB2; GABPB1; RRAGA; H2AFY2; TYR
    protein homodimerization activity PRPS1L1; NUDT21; NR6A1B; ATPIF1A; GDF6; NBL1; E2F8; ACCS; SDS; Bcl2a1b
    protein kinase binding PTPRC; ACTA2; RELA; BCL10; CDH2; TBC1D14; CCND2; TRAF4; CLTC; CCNA2
    scaffold protein binding PARK7; VIM; NLGN4Y; CIT; MAP2K2; GRIN2A; NLRP1; GRID2; MAPK3; KCNA5

    CAV2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAV2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAV2.

    EGFR; CAV1; DNAJA1; GOLGB1; q99ib8-pro_0000045602; ANXA2

    Schubert, M; Panja, D; et al. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. ACTA NEUROPATHOLOGICA 128:835-852(2014).

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