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CBFA2T3

Official Full Name

core-binding factor, runt domain, alpha subunit 2; translocated to, 3
Overview

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5-region of the runt-related transcription factor 1 gene fused to the 3-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
Synonyms

CBFA2T3; core-binding factor, runt domain, alpha subunit 2; translocated to, 3; protein CBFA2T3; MTG16; MTGR2; myeloid translocation gene 8 and 16b; ZMYND4; MTG8-related gene 2; MTG8-related protein 2; zinc finger MYND domain-containing protein 4; myeloid;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
Myc
DDK
MYC
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CBFA2T3-0453H	Recombinant Human CBFA2T3 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CBFA2T3-286HCL	Recombinant Human CBFA2T3 cell lysate		N/A		Inquiry
Human	CBFA2T3-2730H	Recombinant Human CBFA2T3 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	CBFA2T3-2858H	Recombinant Human CBFA2T3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CBFA2T3-2756HF	Recombinant Full Length Human CBFA2T3 Protein, GST-tagged	In Vitro Cell Free System	GST	615 amino acids	Inquiry
Mouse	Cbfa2t3-786M	Recombinant Mouse Cbfa2t3 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Chicken	CBFA2T3-2293C	Recombinant Chicken CBFA2T3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CBFA2T3 involved in several pathways and played different roles in them. We selected most pathways CBFA2T3 participated on our site, such as ErbB4 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBFA2T3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ErbB4 signaling events	WWOX;WWP1;CBFA2T3;YAP1

CBFA2T3 has several biochemical functions, for example, chromatin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBFA2T3 itself. We selected most functions CBFA2T3 had, and list some proteins which have the same functions with CBFA2T3. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	RING1;SP3;FEZF2;PRMT6;GATA1A;YBX1;MSGN1;TOX;NR5A1
metal ion binding	PRDM9;MPO;ZNF567;PDE10A;ENDOG;COL3A1;MCCC1;ZFP82;ATP5S
protein binding	RBM8A;WBP1;ZNF193;C1QTNF9;SLC3A1;LAT;CUL4A;C2orf28;RIOK3
transcription corepressor activity	TLE2;TRIM22;E2F8;SKOR1A;DMAP1;CCND1;DAXX;SSX3;TFCP2L1
transcription factor activity, sequence-specific DNA binding	ARNT;NR3C2;PPARG;TCF3;HOXC6B;ZFP131;FOXI1;ZNF621;KLF4

CBFA2T3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBFA2T3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBFA2T3.

PLXNA3; ZNF652; Prkar1a; ZBTB47; MATN2; SEC24A; ATN1; cotE; uup3; GMEB2; TRIM33