CBLB
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Official Full Name
Cbl proto-oncogene, E3 ubiquitin protein ligase B -
Overview
E3 ubiquitin-protein ligase CBL-B is an enzyme that in humans is encoded by the CBLB gene. -
Synonyms
CBLB;Cbl proto-oncogene, E3 ubiquitin protein ligase B;Cas Br M (murine) ecotropic retroviral transforming sequence b , Cas Br M (murine) ectropic retroviral transforming sequence b;E3 ubiquitin-protein ligase CBL-B;Cbl b;RNF56;RING finger protein
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- Insect cells
- In Vitro Cell Free System
- His
- DDK
- Myc
- GST
- Non
- Avi
- Flag
- Fc
Involved Pathway
CBLB involved in several pathways and played different roles in them. We selected most pathways CBLB participated on our site, such as ErbB signaling pathway,Ubiquitin mediated proteolysis,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBLB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Measles | IFNA6,TNFSF10,GSK3B,CD46,PIK3CA,CD3G,PRKCQ,IL4,IFNA16,CD28 |
| Insulin signaling pathway | PRKCI,MAP2K2,PRKAG1,GRB2,INSRA,SOCS4,PPP1CAB,GSK3AA,TRIP10A,PPP1CB |
| T cell receptor signaling pathway | PAK1,LAT,LCK,PIK3CG,MUC1,PLCG1,MAPK1,RAF1,FOS,PIK3R5 |
| Ubiquitin mediated proteolysis | CUL3,UBE3A,PARK2,UBE2J1,MID1,FBXW11A,UBOX5,UBE3B,SYVN1,CDC26 |
| Proteoglycans in cancer | IL12B,STAT3,WNT9B,PIK3CB,RAF1,CCND1,PPP1CA,WNT9A,PIK3R5,MMP2 |
| Bacterial invasion of epithelial cells | GAB1,ELMO1,SEPT6,ARPC5L,CRKL,CDC42,SEPT3,CLTB,CTNNA1,DOCK1 |
| Pathways in cancer | PRKACA,PIK3R3,TCEB2,TFG,CYCS,PLEKHG5,IL-8,BCL2,TCF7,WNT3A |
| Chronic myeloid leukemia | CRKL,RAF1,GRB2,BCL2L1,BAD,PIK3CD,SHC1,SMAD4,MECOM,TGFB2 |
| ErbB signaling pathway | MAPK8,BAD,PIK3CD,CBL,RAF1B,PAK3,PIK3CA,MAPK10,MAP2K2A,AKT2 |
Protein Function
CBLB has several biochemical functions, for example, calcium ion binding,ligase activity,phosphotyrosine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBLB itself. We selected most functions CBLB had, and list some proteins which have the same functions with CBLB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | MDM2,TRAF6,PDZRN3B,RNF144AB,CBLL1,TRIM9,FBXL6,TNFAIP3,TRIM36,RNF31 |
| phosphotyrosine binding | GRB2,ZAP70,MAPK1,FGR,PTPN3,CBLC,ACP2,CBL,LDLRAP1,SAMSN1 |
| protein binding | KIAA0947,JAKMIP2,BNIP1,POU1F1,TBL1X,SAE1,COPS3,ILF3,DDX3X,FBN2 |
| ligase activity | TRIM8,CTPS1A,SHPRH,TOPORS,MARCH11,CCNB1IP1,XIAP,NEURL3,DZIP3,UBE2L3A |
| calcium ion binding | ANXA11B,MAN1C1,aLA,CDH5,NOTCH2,NCALDA,FAM20C,SYTL3,PCDH2G7,PCDH2AA3 |
| zinc ion binding | Shh,ZNF3,ADAM19,ZCCHC12,ATXN7L3,PHF23A,SIAH1A,LIMS2,MAN2A1,BPTF |
| signal transducer activity | CXCR7B,STMN1,TAAR13B,CC2D1A,AGTR1B,TICAM2,CRKL,VMN1R41,MC5RB,CCR1L1 |
Interacting Protein
CBLB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBLB here. Most of them are supplied by our site. Hope this information will be useful for your research of CBLB.
SH3KBP1
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