CBLB

  • Official Full Name

    Cbl proto-oncogene, E3 ubiquitin protein ligase B
  • Overview

    E3 ubiquitin-protein ligase CBL-B is an enzyme that in humans is encoded by the CBLB gene.
  • Synonyms

    CBLB;Cbl proto-oncogene, E3 ubiquitin protein ligase B;Cas Br M (murine) ecotropic retroviral transforming sequence b , Cas Br M (murine) ectropic retroviral transforming sequence b;E3 ubiquitin-protein ligase CBL-B;Cbl b;RNF56;RING finger protein

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • Insect cells
  • In Vitro Cell Free System
  • His
  • DDK
  • Myc
  • GST
  • Non
  • Avi
  • Flag
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CBLB-10756H Recombinant Human CBLB, His-tagged E.coli Human His N-term-352a.a.
CBLB-733H Recombinant Human CBLB protein, His-tagged E.coli Human His Ala39-Phe426
CBLB-1155R Recombinant Rat CBLB Protein Mammalian Cells Rat His
CBLB-18H Recombinant Human CBLB, MYC/DDK-tagged HEK293 Human DDK&Myc
CBLB-578H Recombinant Human CBLB, GST-tagged Wheat Germ Human GST 1-982 a.a.
CBLB-579H Recombinant Human CBLB, GST-tagged Wheat Germ Human GST 21-129 a.a.
CBLB-7814HCL Recombinant Human CBLB 293 Cell Lysate HEK293 Human Non
CBLB-01H Active Recombinant Human CBLB Protein Insect cells Human
CBLB-036H Recombinant Human CBLB Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Cblb-1974M Recombinant Mouse Cblb Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
CBLB-19H Recombinant Human CBLB Protein, His-Avi-tagged, Biotinylated E.coli Human Avi&His 39-426 a.a.
CBLB-301611H Recombinant Human CBLB protein, GST-tagged E.coli Human GST Met1-His352
CBLB-3615HFL Recombinant Full Length Human CBLB, Flag-tagged Mammalian Cells Human Flag Full L.
CBLB-558HF Recombinant Full Length Human CBLB Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 982 amino acids
CBLB-813R Recombinant Rat CBLB Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
CBLB-813R-B Recombinant Rat CBLB Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    CBLB involved in several pathways and played different roles in them. We selected most pathways CBLB participated on our site, such as ErbB signaling pathway,Ubiquitin mediated proteolysis,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBLB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bacterial invasion of epithelial cells SEPT11,WAS,ARPC2,DNM2,CRK,PIK3R3,CAV2,SEPT3,GAB1,ARPC5L
    T cell receptor signaling pathway PIK3CG,PLCG1,PTPRC,MAPK13,PPP3CA,EVLB,CD8B1,MAPK1,SOS1,DLG1
    ErbB signaling pathway PRKCA,SHC3,PAK3,RPS6KB1B,MAPK1,CAMK2D1,SHC1,ERBB4,CDKN1BA,ARAF
    Measles NFKBIA,CD209A,IFNA7,CCND3,TP73,GSK3B,EIF2AK1,IFNB1,TNFRSF10A,IRF7
    Ubiquitin mediated proteolysis UBE2H,PML,FZR1,SIAH1,UBOX5,TCEB1B,TRIM32,UBA6,ITCHA,UBE2IA
    Endocytosis ARAP3,IGF1RB,EHD2,ASAP3,SH3GLB2,EGFRA,FAM21C,AGAP1,ADRB2A,PDCD6IP
    Proteoglycans in cancer WNT9A,MTOR,MAPK13,PPP1R12B,PRKACG,MRAS,TP53,MAPK11,MSN,SRC
    Pathways in cancer NTRK1,RARB,RAC1,CBL,CASP8,FIGF,WNT9B,BCL2L1,LAMA4,MDM2
    Chronic myeloid leukemia HDAC1,TGFBR1,HDAC2,MDM2,CRK,MECOM,STAT5B,SMAD4,RELA,CBL

    Protein Function

    CBLB has several biochemical functions, for example, calcium ion binding,ligase activity,phosphotyrosine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBLB itself. We selected most functions CBLB had, and list some proteins which have the same functions with CBLB. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity RNF135,CCNB1IP1,MARCH11,UBE2KB,DZIP3,NHLRC1,RNF187,MUL1,TRIML1,TRIM33
    signal transducer activity PLCB2,OLFR492,CAPN3,GNAI2,IL11RA,VMN1R45,TRAF5,C18orf32,TAS2R137,SH2B1
    phosphotyrosine binding LDLRAP1,MAPK1,ACP2,ZAP70,MAPK3,GRB2,PTPN3,SAMSN1,STAP1,FGR
    protein binding ZNF460,TCTEX1D2,NCL,PDK1,DLG3,MTDH,INCENP,ZBED3,ARVCF,SOCS7
    ubiquitin-protein transferase activity RNF213,FBXL21,MARCH6,BIRC5B,ZNRF3,FBXW2,PEX2,RLIM,UBR3,UBA1
    zinc ion binding FAM90A1,MMP14,KAT6B,BTR18,QTRTD1,USP13,CA15B,HERC2,CSRP1,WBP4
    calcium ion binding PLSCR3,NKD1,PPP3R1B,CABYR,CALM1,CDH15,PCDHB14,PCDH10B,OTOFA,RHOT1A

    Interacting Protein

    CBLB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBLB here. Most of them are supplied by our site. Hope this information will be useful for your research of CBLB.

    SH3KBP1

    Resources

    References

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