CCR5

  • Official Full Name

    chemokine (C-C motif) receptor 5 (gene/pseudogene)

  • Overview

    This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Alouatta seniculus (Red howler monkey)
  • Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey)
  • Bos taurus (Bovine)
  • Callithrix humeralifera (Tassel-eared marmoset)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
  • Cercocebus galeritus (Tana river mangabey)
  • Cercopithecus ascanius (Black-cheeked white-nosed monkey) (Redtail monkey)
  • Cercopithecus cephus (Moustached monkey)
  • Cercopithecus lhoesti (L'Hoest's monkey)
  • Cercopithecus nictitans (Greater white-nosed monkey) (White-nosed guenon)
  • Cercopithecus solatus (Sun-tailed monkey)
  • Chicken
  • Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
  • Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus)
  • Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
  • Chlorocebus tantalus (Tantalus monkey) (Cercopithecus tantalus)
  • Colobus polykomos (Western black-and-white colobus monkey)
  • Erythrocebus patas (Red guenon) (Cercopithecus patas)
  • Gorilla gorilla gorilla (Western lowland gorilla)
  • Homo sapiens (Human)
  • Human
  • Hylobates moloch (Silvery gibbon)
  • Lophocebus aterrimus (Black crested mangabey) (Cercocebus aterrimus)
  • Macaca arctoides (Stump-tailed macaque)
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Macaca mulatta (Rhesus macaque)
  • Macaca nemestrina (Pig-tailed macaque)
  • Mandrillus leucophaeus (Drill) (Papio leucophaeus)
  • Mandrillus sphinx (Mandrill) (Papio sphinx)
  • Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin)
  • Mouse
  • Mus musculus (Mouse)
  • Nasalis larvatus (Proboscis monkey)
  • Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
  • Oryctolagus cuniculus (Rabbit)
  • Pan paniscus (Pygmy chimpanzee) (Bonobo)
  • Pan troglodytes (Chimpanzee)
  • Papio anubis (Olive baboon)
  • Papio hamadryas (Hamadryas baboon)
  • Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Pongo pygmaeus (Bornean orangutan)
  • Pygathrix nemaeus (Red-shanked douc langur)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Rhinopithecus avunculus (Tonkin snub-nosed monkey) (Pygathrix avunculus)
  • Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
  • Saimiri sciureus (Common squirrel monkey)
  • Semnopithecus entellus (Hanuman langur) (Presbytis entellus)
  • Symphalangus syndactylus (Siamang) (Hylobates syndactylus)
  • Theropithecus gelada (Gelada baboon)
  • Trachypithecus francoisi (Francois' leaf monkey) (Presbytis francoisi)
  • Trachypithecus johnii (Nilgiri langur) (Semnopithecus johnii)
  • Trachypithecus phayrei (Phayre's leaf monkey)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Flag
  • His
  • GST
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCR5-366H Human CCR5 peptide N/A
Human CCR5-120H Recombinant Human CCR5, GST-tagged Wheat Germ GST
Human CCR5-10886H Recombinant Human CCR5, GST-tagged E.coli GST
Human CCR5-0693H Recombinant Human CCR5 Protein Wheat Germ N/A
Human CCR5-309HCL Recombinant Human CCR5 cell lysate HEK293T Flag
Human CCR5-644H Recombinant Human CCR5 Protein, His-tagged E.coli N-His
Human CCR5-192H Recombinant Human CCR5 Protein, His-tagged E.coli His
Human CCR5-681H Recombinant Human CCR5 protein, Flag & His-tagged HEK293 Flag/His
Human CCR5-2356H Recombinant Human CCR5 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His
Human CCR5-1075HFL Recombinant Human CCR5 protein, His&Flag-tagged HEK293 His&Flag
Human CCR5-582H Active Recombinant Human CCR5 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CCR5-0621H Active Recombinant Human CCR5 Full Length Transmembrane protein(VLPs) HEK293 N/A
Human CCR5-3019HF Recombinant Full Length Human CCR5 Protein In Vitro Cell Free System
Human CCR5-0881H Recombinant Human CCR5 Protein (Glu302-Leu352), N-GST tagged E.coli N-GST
Mouse CCR5-3016M Recombinant Mouse CCR5 Protein Mammalian Cell His
Mouse CCR5-1423M Recombinant Mouse CCR5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ccr5-5363M Recombinant Mouse Ccr5 protein, His-tagged Yeast His
Mouse CCR5-1423M-B Recombinant Mouse CCR5 Protein Pre-coupled Magnetic Beads HEK293
Rat CCR5-1229R Recombinant Rat CCR5 Protein Mammalian Cell His
Rat CCR5-887R-B Recombinant Rat CCR5 Protein Pre-coupled Magnetic Beads HEK293
Rat CCR5-887R Recombinant Rat CCR5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Alouatta seniculus (Red howler monkey) RFL35533AF Recombinant Full Length Alouatta Seniculus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey) RFL10433AF Recombinant Full Length Ateles Geoffroyi C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Bos taurus (Bovine) RFL21302BF Recombinant Full Length Bovine C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Callithrix humeralifera (Tassel-eared marmoset) RFL24548CF Recombinant Full Length Callithrix Humeralifera C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Canis lupus familiaris (Dog) (Canis familiaris) RFL13344CF Recombinant Full Length Dog C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) RFL31667CF Recombinant Full Length Cercocebus Atys C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Cercocebus galeritus (Tana river mangabey) RFL27689CF Recombinant Full Length Cercocebus Galeritus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Cercopithecus ascanius (Black-cheeked white-nosed monkey) (Redtail monkey) RFL33428CF Recombinant Full Length Cercopithecus Ascanius C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Cercopithecus cephus (Moustached monkey) RFL15218CF Recombinant Full Length Cercopithecus Cephus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Cercopithecus lhoesti (L'Hoest's monkey) RFL23095CF Recombinant Full Length Cercopithecus Lhoesti C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Cercopithecus nictitans (Greater white-nosed monkey) (White-nosed guenon) RFL34443CF Recombinant Full Length Cercopithecus Nictitans C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Cercopithecus solatus (Sun-tailed monkey) RFL15423CF Recombinant Full Length Cercopithecus Solatus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) RFL8947CF Recombinant Full Length Chlorocebus Aethiops C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus) RFL33429CF Recombinant Full Length Cercopithecus Pygerythrus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) RFL26666CF Recombinant Full Length Cercopithecus Sabaeus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Chlorocebus tantalus (Tantalus monkey) (Cercopithecus tantalus) RFL22568CF Recombinant Full Length Cercopithecus Tantalus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Colobus polykomos (Western black-and-white colobus monkey) RFL24151CF Recombinant Full Length Colobus Polykomos C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Erythrocebus patas (Red guenon) (Cercopithecus patas) RFL30588EF Recombinant Full Length Erythrocebus Patas C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Gorilla gorilla gorilla (Western lowland gorilla) RFL14297GF Recombinant Full Length Gorilla Gorilla Gorilla C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Homo sapiens (Human) RFL7742HF Recombinant Full Length Human C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Hylobates moloch (Silvery gibbon) RFL12430HF Recombinant Full Length Hylobates Moloch C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Lophocebus aterrimus (Black crested mangabey) (Cercocebus aterrimus) RFL28342LF Recombinant Full Length Lophocebus Aterrimus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Macaca arctoides (Stump-tailed macaque) RFL2096MF Recombinant Full Length Macaca Arctoides C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL8323MF Recombinant Full Length Macaca Fascicularis C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Macaca mulatta (Rhesus macaque) RFL34221MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Macaca nemestrina (Pig-tailed macaque) RFL2328MF Recombinant Full Length Macaca Nemestrina C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Mandrillus leucophaeus (Drill) (Papio leucophaeus) RFL12648MF Recombinant Full Length Mandrillus Leucophaeus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Mandrillus sphinx (Mandrill) (Papio sphinx) RFL18955MF Recombinant Full Length Mandrillus Sphinx C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin) RFL32904MF Recombinant Full Length Miopithecus Talapoin C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Mus musculus (Mouse) RFL36863MF Recombinant Full Length Mouse C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Nasalis larvatus (Proboscis monkey) RFL17469NF Recombinant Full Length Nasalis Larvatus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) RFL6961NF Recombinant Full Length Nomascus Leucogenys C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Oryctolagus cuniculus (Rabbit) RFL10222OF Recombinant Full Length Rabbit C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Pan paniscus (Pygmy chimpanzee) (Bonobo) RFL9058PF Recombinant Full Length Pan Paniscus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Pan troglodytes (Chimpanzee) RFL4879PF Recombinant Full Length Pan Troglodytes C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Papio anubis (Olive baboon) RFL5405PF Recombinant Full Length Papio Anubis C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Papio hamadryas (Hamadryas baboon) RFL395PF Recombinant Full Length Papio Hamadryas C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch) RFL11067PF Recombinant Full Length Callicebus Moloch C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL11898PF Recombinant Full Length Pongo Abelii C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Pongo pygmaeus (Bornean orangutan) RFL8108PF Recombinant Full Length Pongo Pygmaeus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Pygathrix nemaeus (Red-shanked douc langur) RFL21885PF Recombinant Full Length Pygathrix Nemaeus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL29360RF Recombinant Full Length Rat C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Rhesus Macaque CCR5-708R Recombinant Rhesus monkey CCR5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCR5-535R Recombinant Rhesus Macaque CCR5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CCR5-535R-B Recombinant Rhesus Macaque CCR5 Protein Pre-coupled Magnetic Beads HEK293
Rhinopithecus avunculus (Tonkin snub-nosed monkey) (Pygathrix avunculus) RFL9040RF Recombinant Full Length Rhinopithecus Avunculus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) RFL30958RF Recombinant Full Length Pygathrix Bieti C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Saimiri sciureus (Common squirrel monkey) RFL21921SF Recombinant Full Length Saimiri Sciureus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Semnopithecus entellus (Hanuman langur) (Presbytis entellus) RFL16003SF Recombinant Full Length Semnopithecus Entellus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Symphalangus syndactylus (Siamang) (Hylobates syndactylus) RFL18010SF Recombinant Full Length Hylobates Syndactylus C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Theropithecus gelada (Gelada baboon) RFL16162TF Recombinant Full Length Theropithecus Gelada C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Trachypithecus francoisi (Francois' leaf monkey) (Presbytis francoisi) RFL3326TF Recombinant Full Length Trachypithecus Francoisi C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Trachypithecus johnii (Nilgiri langur) (Semnopithecus johnii) RFL11986TF Recombinant Full Length Trachypithecus Johnii C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Trachypithecus phayrei (Phayre's leaf monkey) RFL15899TF Recombinant Full Length Trachypithecus Phayrei C-C Chemokine Receptor Type 5(Ccr5) Protein, His-Tagged E.coli expression system His
Chicken CCR5-4659C Recombinant Chicken CCR5 Mammalian Cell His
Kit-0889 Hydroxyl Free Radical Assay Kit N/A
Kit-1048 NAD+/NADH Colorimetric Assay Kit (384-well) N/A
Kit-1154 CCR5 Activated GPCR Internalization Assay Kit N/A
Kit-1153 CCR5 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1155 cAMP CCR5 CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CCR5 Related Articles
  • CCR5 Related Gene Family
  • CCR5 Related Research Area

CCR5 involved in several pathways and played different roles in them. We selected most pathways CCR5 participated on our site, such as Binding and entry of HIV virion, Chemokine receptors bind chemokines, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Binding and entry of HIV viriongag;PPIA;CCR5
Chemokine receptors bind chemokinesCXCL13;CCL35.1;CCR3;CXCL11.8;CCL35.2;CXCR7B;CXCR6;AMCF-II;CCR5
Chemokine signaling pathwayCXCL2;CCL6;GNG12;NRAS;CXCL14;CCR6;CXCR6;CCR7;GNG2
Class A/1 (Rhodopsin-like receptors)SST;GRP;ADORA1;AGTR1;CNR2;EDN1;AGT;SSTR5;OPN1SW1
Cytokine-cytokine receptor interactionTNFSF10;CCR6A;KIT;CCL6;PDGFB;GM10591;CCL24;TNFRSF10B;LIFRA
DiseaseWHSC2;SSRP1;TNKS;FKBP1A;NA;CTBP2;AP1B1;PSIP1;MYO18A
Early Phase of HIV Life CycleBANF1;PPIA;PSIP1;gag;CCR5
EndocytosisARRB1;MDM2;ARPC4L;SH3GLB1;RAB11FIP1;ARPC3;SNX5;MHC1UEA;ARPC4

CCR5 has several biochemical functions, for example, C-C chemokine binding, C-C chemokine receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR5 itself. We selected most functions CCR5 had, and list some proteins which have the same functions with CCR5. You can find most of the proteins on our site.

Function Related Protein
C-C chemokine bindingDARC;CCBP2;CCR5;CCR1;ZFP36
C-C chemokine receptor activityCCR1;CCR1L1;CCR3;CCR7;CCBP2;CCR5;GPR75;CCR8;CCR6
actin bindingMYO1C;MYO5A;CXCR4;SHROOM2;MED28;MYH6;GCSAM;INPPL1B;CAPZA1A
chemokine (C-C motif) ligand 5 bindingCCR5;CCR1
chemokine receptor activityCXCR3.1;PRLH2R;CX3CR1;CCR1L1;CXCR4B;CCR1;RGRB;XCR1;ACKR4
coreceptor activityCCR5;ACVR2A;RGMD;RGMB;TGFBR3;CD4;CD8A;CXCR6;HFE2
phosphatidylinositol phospholipase C activityBDKRB2;CHRM1;CCR1;PLCD1;PLCD3A;CHRM3;CCR5;PLCZ1;EDNRA
protein bindingNBR1;PSMD11;PGM1;NDFIP1;XIAP;MCM3;O3far1;DES;FAIM
virus receptor activityLAMP1;ITGB7;NPC1;IDE;TNFRSF4;ITGA2;CD209;CXADR;CR2

CCR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR5.

CD4; PRAF2; CCL5; CXCR4; ARL6IP5; CCL4; MYH9; CREB3; ETV5; CTBP2; IL24

Gardner, MR; Kattenhorn, LM; et al. AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. NATURE 519:87-U173(2015).
Yi, HA; Diaz-Rohrer, B; et al. The Membrane Proximal External Regions of gp41 from HIV-1 Strains HXB2 and JRFL Have Different Sensitivities to Alanine Mutation. BIOCHEMISTRY 54:1681-1693(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the main function of CCR5 protein in the human body? 04/12/2022

In the human body, CCR5 protein is mainly involved in the regulation of the immune system, it acts as a chemokine receptor, which can sense the signal of the site of inflammation and guide immune cells to reach the site of inflammation, thus playing a role in immune response.

How about the unsolved questions or future research directions for CCR5 protein? 03/15/2021

There are still many unsolved questions and future research directions for CCR5 protein. For example, we need to better understand the structure-function relationship of CCR5, explore the interaction of CCR5 with other proteins and their potential implications, and develop more potent and selective CCR5 antagonists.

In immunotherapy, how to use the function of CCR5 for disease treatment? 09/10/2020

In immunotherapy, the function of CCR5 can be used for disease treatment, such as affecting the migration and activation of immune cells by regulating the expression or function of CCR5, so as to achieve the purpose of treating inflammatory diseases or autoimmune diseases. In addition, antibodies or antagonists against CCR5 may also be considered to inhibit its binding to ligands to further modulate the immune response.

What is the interaction of CCR5 protein with other receptors or signaling pathways? 08/18/2020

CCR5 protein can interact with other receptors and signaling pathways. For example, in some cancer cells, CCR5 binds to EGFR (epidermal growth factor receptor), triggering EGFR activation and promoting tumor cell growth and metastasis. In addition, CCR5 is also involved in the regulation of signaling pathways such as MAPK (mitogen-activated protein kinase) and PI3K (phosphatidylinositol kinase).

How can gene editing technology be used to modify or treat the CCR5 gene? 06/13/2020

Gene editing technology such as CRISPR-Cas9 can be used to modify or treat the CCR5 gene. By editing the CCR5 gene, the expression of CCR5 protein can be regulated or its function can be changed. This technique is expected to be used in the future to treat some genetic diseases or cancers associated with CCR5.

How can CCR5 protein be used for disease treatment? 05/29/2020

One way to use CCR5 protein for disease treatment is to use CCR5 antagonists, which are drugs that prevent CCR5 from binding to ligands. There are already a number of CCR5 antagonists in clinical trials for the treatment of diseases such as AIDS and rheumatoid arthritis.

Customer Reviews (3)

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Reviews
04/04/2023

    When experiments are performed with CCR5, stable and reproducible results can be obtained.

    01/13/2023

      CCR5 has a high yield and good economic benefits.

      07/12/2022

        CCR5 exerts the expected biological effects in experiments.

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